期刊
MOVEMENT DISORDERS
卷 23, 期 10, 页码 1461-1465出版社
WILEY-LISS
DOI: 10.1002/mds.22143
关键词
Parkinson's disease; parkin; PINK1; digenic; psychiatric disorder
To clarify the genetic correlation between parkin and PINK1, we screened for PINK1 mutations in 175 parkinsonism patients with parkin mutations. We detected two sibling pairs and one sporadic patient carrying both parkin and PINK1 mutations. The age at onset of Parkinsonism of patients with the digenic mutations was lower than that of patients with the same parkin mutation alone. In addition, two of three patients carrying both parkin and PINK1 mutations had schizophrenia. These findings indicate that PINK1 mutation might modify parkin mutation-positive Parkinsonism, and PINK-1 mutations might be associated with psychiatric disorders. (C) 2008 Movement Disorder Society.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据