Article
Clinical Neurology
Gianpaolo Maggi, Carmine Vitale, Francesco Cerciello, Gabriella Santangelo
Summary: Sleep disorders are common in Parkinson's disease and have variable prevalence rates. They are multifactorial in etiology, resulting from degenerative processes, drug interactions, and clinical features. A meta-analytic study found that RBD had a prevalence of 46% and was associated with older age, lower education, longer disease duration, higher medication doses, and more severe symptoms. EDS had a prevalence of 35% and was associated with older age, longer disease duration, more severe symptoms, higher medication doses, and reduced autonomy. Insomnia was reported in 44% of patients and was related to longer disease duration, higher medication doses, and more severe depression. Sleep disorders are associated with a more severe clinical phenotype of Parkinson's disease, and further research is needed to understand their underlying mechanisms and develop targeted therapies.
SLEEP MEDICINE REVIEWS
(2023)
Article
Nutrition & Dietetics
Muhammed Tunc, Pinar Soysal, Ozge Pasin, Lee Smith, Masoud Rahmati, Veliye Yigitalp, Sevnaz Sahin, Moustapha Drame
Summary: The aim of this study was to investigate the relationship between serum magnesium levels and insomnia and excessive daytime sleepiness (EDS) in older adults. It found that hypomagnesemia was associated with a higher prevalence of EDS but not insomnia in older outpatients. Other health conditions such as hypertension and diabetes mellitus were also more common in the hypomagnesemia group. These findings suggest that hypomagnesemia should be considered when evaluating older adults with EDS.
Article
Clinical Neurology
Keitaro Ogaki, Hiroaki Fujita, Narihiro Nozawa, Tomohiko Shiina, Hirotaka Sakuramoto, Keisuke Suzuki
Summary: The study aimed to identify the contributors to sleep disturbances, including insomnia, restless legs syndrome, rapid eye movement sleep behavior disorder (RBD), sleep-disordered breathing, nocturnal akinesia and excessive daytime sleepiness (EDS), in patients with Parkinson's disease (PD). The results showed that autonomic symptoms were associated with sleep disturbances or EDS, and depressive and RBD symptoms in addition to autonomic symptoms were associated with both sleep disturbances and EDS in patients with PD.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Jean-Christophe Corvol, Jean-Philippe Azulay, Bjorn Bosse, Yves Dauvilliers, Luc Defebvre, Fabian Klostermann, Norbert Kovacs, David Maltete, William G. Ondo, Rajesh Pahwa, Werner Rein, Stephane Thobois, Martin Valis, Aleksandar Videnovic, Olivier Rascol
Summary: The study of THN102 in PD patients with EDS showed that the 200/2 dose demonstrated efficacy and good tolerability, supporting further development. On the other hand, the 200/18 dose did not show significant improvement.
MOVEMENT DISORDERS
(2022)
Article
Behavioral Sciences
Yuan Shen, Haicun Shi, JianGuo Zhong, PingLei Pan, ShuFang Wang, MingZhu Chen, ZhiPeng Chen, ChunFeng Liu
Summary: This study aimed to explore the factors correlated with excessive daytime sleepiness (EDS) in patients with Parkinson's disease (PD). The findings revealed that fatigue and respiratory-related microarousal index were independent risk factors for EDS in PD patients. Fragmented sleep and pathological abnormalities of the central nervous system resulting in changes in arousal are speculated to be major influencing factors of EDS in PD.
BRAIN AND BEHAVIOR
(2023)
Article
Clinical Neurology
Yezhou Li, Jing Wang, Lirong Ji, Chaohong Cheng, Tong Su, Shuqing Wu, Fei Han, Daniel J. Cox, Erlei Wang, Rui Chen
Summary: This study aims to investigate the effects of excessive daytime sleepiness on cortical thickness in patients with obstructive sleep apnoea. It was found that the cortical thickness was significantly thinner in the sleepiness group, particularly in the left temporal, frontal, and parietal lobe, and bilateral pre- and postcentral gyri. There was a significant negative correlation between the cortical thickness and the Epworth Sleepiness Scale score.
FRONTIERS IN NEUROLOGY
(2023)
Article
Psychology, Social
Joshua Tutek, William K. Wohlgemuth, Kenneth L. Lichstein
Summary: The study investigated whether trait mindfulness predicts daytime impairment caused by poor sleep. Mindfulness was found to have strong negative correlations with nighttime and daytime sleep symptoms.
PERSONALITY AND INDIVIDUAL DIFFERENCES
(2021)
Article
Clinical Neurology
Zhen-Zhen Liu, Cun-Xian Jia, Xianchen Liu
Summary: The study found that insomnia symptoms and excessive daytime sleepiness were associated with suicidal behavior in adolescents, and excessive daytime sleepiness mediated the link between insomnia symptoms and suicidal behavior.
Review
Clinical Neurology
Fei Feng, YingYing Cai, YanBing Hou, Ruwei Ou, Zheng Jiang, HuiFang Shang
Summary: The study found that approximately one-third of patients with Parkinson's disease (PD) had excessive daytime sleepiness (EDS), which may be associated with the severity of the disease, depression symptoms, male sex, and medication.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Anatilde Trindade, Catarina Custodio, Jorge Cabral, Telma Lopes, Vera Martins, Margarida Aguiar, Ines Goncalves, Sofia Furtado
Summary: This study aimed to compare the adherence to positive airway pressure (PAP) therapy between patients with or without excessive daytime sleepiness (EDS) in different severities of obstructive sleep apnea (OSA). The results showed that there were differences in adherence between patients with different severities of OSA but without EDS. However, there was no difference in adherence between patients with or without EDS, regardless of the severity.
Article
Clinical Neurology
Xiaoying Zhang, Sheng Zhuang, Jiajing Wu, Lanxiang Wang, Chengjie Mao, Jing Chen, Chun-feng Liu
Summary: Low frequency rTMS over right DLPFC may improve symptoms of excessive daytime sleepiness in Parkinson's disease patients. This study provides new possibilities for the treatment of EDS.
Article
Clinical Neurology
Ming Liu, Ya-Jun Luo, Han-Ying Gu, Yi-Ming Wang, Man-Hua Liu, Kai Li, Jiao Li, Sheng Zhuang, Yun Shen, Hong Jin, Jing Chen, Cheng-Jie Mao, Chun-Feng Liu
Summary: Gender and age at onset have an impact on excessive daytime sleepiness and night-time sleep quality in Parkinson's disease patients. Depression is a common risk factor for both EDS and poor sleep quality in PD patients. More attention is needed for sleep disorders in male late-onset PD patients.
Article
Clinical Neurology
Henrik Holtstrand Hjalm, Erik Thunstrom, Helena Glantz, Martin Karlsson, Yeliz Celik, Yuksel Peker
Summary: There is an independent and dose-response relationship between the severity of obstructive sleep apnea (OSA) and prevalent atrial fibrillation (AF), especially among individuals without excessive daytime sleepiness (EDS).
Article
Clinical Neurology
Elisabetta Fasiello, Samantha Mombelli, Marco Sforza, Marco Zucconi, Francesca Casoni, Konstantina Chadia, Vincenza Castronovo, Paschalis Steiropoulos, Luigi De Gennaro, Luigi Ferini-Strambi, Andrea Galbiati
Summary: The study found that patients with insomnia disorder do not often report sleepiness, indicating an independent relationship between daytime functioning and sleepiness. Cognitive behavioral therapy can improve daytime consequences and fatigue, but it also increases sleepiness. These results suggest that patients with insomnia experience a heightened state of arousal even during wakefulness.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Yang Hu, Peng Guo, Teng-Hong Lian, Li-Jun Zuo, Shu-Yang Yu, Li Liu, Zhao Jin, Qiu-Jin Yu, Rui-Dan Wang, Li-Xia Li, Ying-Shan Piao, Wei Zhang
Summary: The study found that excessive daytime sleepiness is a common symptom in patients with Parkinson's disease, which is associated with more severe motor and non-motor symptoms, and overloaded iron-relevant inflammation in the brain might be an underlying mechanism of PD-EDS.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Rehabilitation
Daphne J. Geerse, Melvyn Roerdink, Johan Marinus, Jacobus J. van Hilten
Summary: The study aimed to evaluate the potential of the Interactive Walkway as a new technology for assessing walking adaptability in stroke patients. Results demonstrated good known-groups validity for walking-adaptability outcomes, with only moderate correlations with clinical test scores and gait parameters. The Interactive Walkway walking-adaptability outcomes complement standard clinical tests and spatiotemporal gait parameters.
DISABILITY AND REHABILITATION
(2021)
Article
Public, Environmental & Occupational Health
Janneke D. M. Verberk, Stephanie M. van Rooden, Mayke B. G. Koek, David J. Hetem, Annelies E. Smilde, Wendy S. Bril, Roel H. R. A. Streefkerk, Titia E. M. Hopmans, Marc J. M. Bonten, Sabine C. de Greeff, Maaike S. M. van Mourik
Summary: The study evaluated the validity of a semiautomated surveillance algorithm for deep SSIs after THA or TKA in Dutch hospitals, showing that the algorithm can reliably detect patients with a high probability of developing deep SSIs and significantly reduce workload.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2021)
Article
Medicine, General & Internal
Rene Post, Menno R. Germans, Maud A. Tjerkstra, Mervyn D. I. Vergouwen, Korne Jellema, Radboud W. Koot, Nyika D. Kruyt, Peter W. A. Willems, Jasper F. C. Wolfs, Frits C. de Beer, Hans Kieft, Dharmin Nanda, Bram van der Pol, Gerwin Roks, Frank de Beer, Patricia H. A. Halkes, Loes J. A. Reichman, Paul J. A. M. Brouwers, Renske M. van den Berg-Vos, Vincent I. H. Kwa, C. van der Ree, Irene Bronner, Janneke van de Vlekkert, Henri P. Bienfait, Hieronymus D. Boogaarts, Catharina J. M. Klijn, Rene van den Berg, Bert A. Coert, Janneke Horn, Charles B. L. M. Majoie, Gabriel J. E. Rinkel, Yvo B. W. E. M. Roos, W. Peter Vandertop, Dagmar Verbaan
Summary: In patients with aneurysmal subarachnoid haemorrhage, ultra-early, short-term treatment with tranexamic acid did not improve clinical outcomes at 6 months, as measured by the modified Rankin Scale.
Article
Neurosciences
Arlin Keo, Oleh Dzyubachyk, Jeroen van der Grond, Anne Hafkemeijer, Wilma D. J. van de Berg, Jacobus J. van Hilten, Marcel J. T. Reinders, Ahmed Mahfouz
Summary: Structural covariance networks in healthy brains reveal upregulation of genes associated with serotonin, GPCR, GABA, glutamate, and RAS-signaling pathways. The involvement of the cholinergic circuit, as well as genes associated with neuropsychiatric disorders, may play a role in Parkinson's disease pathology. The disruption of healthy functions in cingulate networks could contribute to Parkinson's disease clinical events.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Infectious Diseases
Maaike S. M. van Mourik, Stephanie M. van Rooden, Mohamed Abbas, Olov Aspevall, Pascal Astagneau, Marc J. M. Bonten, Elena Carrara, Aina Gomila-Grange, Sabine C. de Greeff, Sophie Gubbels, Wendy Harrison, Hilary Humphreys, Anders Johansson, Mayke B. G. Koek, Brian Kristensen, Alain Lepape, Jean-Christophe Lucet, Siddharth Mookerjee, Pontus Naucler, Zaira R. Palacios-Baena, Elisabeth Presterl, Miquel Pujol, Jacqui Reilly, Christopher Roberts, Evelina Tacconelli, Daniel Teixeira, Thomas Tangden, John Karlsson Valik, Michael Behnke, Petra Gastmeier
Summary: This paper discusses the transition of automated surveillance (AS) from research setting to large-scale implementation, providing guidance on surveillance target selection, organizational and methodological approaches, key performance requirements of AS systems, successful implementation, and future research directions.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Infectious Diseases
Michael Behnke, John Karlsson Valik, Sophie Gubbels, Daniel Teixeira, Brian Kristensen, Mohamed Abbas, Stephanie M. van Rooden, Petra Gastmeier, Maaike S. M. van Mourik
Summary: This document, published in 2021 by the European Society of Clinical Microbiology and Infectious Diseases on behalf of Elsevier Ltd, provides an overview of implementing an automated surveillance system for Healthcare-associated infections (HAI) in a clinical environment.
Written by a task force within the PRAISE network, it offers detailed guidance on key e-health aspects, data storage and structure, IT infrastructure organization, data standardization, interoperability, algorithms, and technical aspects of accessing, storing, and sharing healthcare data for HAI surveillance.
With the support of this document, along with the PRAISE roadmap and governance documents, readers will have comprehensive guidance on implementing large-scale automated surveillance in a healthcare network.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Infectious Diseases
Stephanie M. van Rooden, Olov Aspevall, Elena Carrara, Sophie Gubbels, Anders Johansson, Jean-Christophe Lucet, Siddharth Mookerjee, Zaira R. Palacios-Baena, Elisabeth Presterl, Evelina Tacconelli, Mohamed Abbas, Michael Behnke, Petra Gastmeier, Maaike S. M. van Mourik
Summary: Strict governance is essential in surveillance networks, especially when manual decisions are replaced by algorithms and routine-care data is reused. Key considerations for AS networks include participation and inclusion, trust in data quality, accountability, and transparency. Involvement of stakeholders and legal specialists early in AS network development is crucial for endorsement and compliance.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Public, Environmental & Occupational Health
Janneke D. M. Verberk, Stephanie M. van Rooden, David J. Hetem, Herman F. Wunderink, Anne L. M. Vlek, Corianne Meijer, Eva A. H. van Ravensbergen, Elisabeth G. W. Huijskens, Saara J. Vainio, Marc J. M. Bonten, Maaike S. M. van Mourik
Summary: This study investigated the reliability and validity of surgical site infection (SSI) surveillance after colorectal surgery in the Netherlands. The study found that raters were consistent in their SSI-ascertainment (good reliability), but improvements can be made regarding the accuracy (moderate validity). Accuracy of surveillance may be improved by providing regular training, adapting definitions to reduce subjectivity, and by supporting surveillance through automation.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Article
Public, Environmental & Occupational Health
J. D. M. Verberk, S. J. S. Aghdassi, M. Abbas, P. Naucler, S. Gubbels, N. Maldonado, Z. R. Palacios-Baena, A. F. Johansson, P. Gastmeier, M. Behnke, S. M. van Rooden, M. S. M. van Mourik
Summary: This study describes the design and implementation of AS systems in Europe, highlighting differences in methods, data sources, and targeted HAIs. AS systems can reduce workload for hospital staff, but implementation barriers include strict data security regulations and the establishment of information technology infrastructure.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Clinical Neurology
Hendrikus J. A. van Os, Dagmar Verbaan, Ynte M. Ruigrok, Paul Dennesen, Marcella C. A. Muller, Bert A. Coert, Mervyn D. Vergouwen, Marieke J. H. Wermer
Summary: This study investigated whether young patients with a history of migraine who had aneurysmal subarachnoid hemorrhage (aSAH) were at increased risk of delayed cerebral ischemia. The results showed that young aSAH patients under 50 years of age with a history of migraine were not at increased risk of delayed cerebral ischemia.
Article
Clinical Neurology
Annemijn M. Algra, Jacoba P. Greving, Jordi de Winkel, Arttu Kurtelius, Kamil Laban, Dagmar Verbaan, Rene van den Berg, William Vandertop, Antti Lindgren, Timo Krings, Peter Y. M. Woo, George K. C. Wong, Bob Roozenbeek, Adriaan C. G. M. van Es, Ruben Dammers, Nima Etminan, Hieronymus Boogaarts, Tristan van Doormaal, Albert van der Zwan, Irene C. van der Schaaf, Gabriel J. E. Rinkel, Mervyn D. I. Vergouwen
Summary: The study aimed to develop risk scores for complications of endovascular and microneurosurgical treatment to improve management decisions for patients with unruptured intracranial aneurysms. By studying the relationship between consistency and risk factors, corresponding predictive models were derived.
Article
Clinical Neurology
L. Kuiper, M. Sanchez van Kammen, B. A. Coert, D. Verbaan, B. J. Emmer, J. M. Coutinho, R. van den Berg
Summary: One-third of patients with dural AVFs in this study were diagnosed with cerebral venous thrombosis. In almost two-thirds of patients, cerebral venous thrombosis was diagnosed prior to or concurrent with the dural AVF. In 97% of patients, there was an anatomic association between the dural AVF and cerebral venous thrombosis.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Editorial Material
Clinical Neurology
Menno R. Germans, Wouter J. Dronkers, M. Irem Baharoglu, Rene Post, Dagmar Verbaan, Gabriel J. E. Rinkel, Yvo B. W. E. M. Roos
Article
Clinical Neurology
Liselore A. Mensing, Rick J. van Tuijl, Jacoba P. Greving, Birgitta K. Velthuis, Irene C. van der Schaaf, Marieke J. H. Wermer, Dagmar Verbaan, W. Peter Vandertop, Nicolaas P. A. Zuithoff, Gabriel J. E. Rinkel, Ynte M. Ruigrok
Summary: This study assessed the effectiveness of screening for UIAs in first-degree relatives (FDRs) of patients with UIA, finding a low rupture risk and no negative impact on quality of life.
Review
Clinical Neurology
K. Mariam Slot, Dagmar Verbaan, Dennis R. Buis, Linda J. Schoonmade, Bart N. M. Berckel, W. Peter Vandertop
Summary: This study systematically reviewed literature on PET imaging in meningiomas and found that SUV and T/N ratio in 18F-FDG PET may be useful for differentiating benign from malignant meningiomas, with T/N ratio showing high specificity for detecting high-grade tumors. Prospective studies in larger cohorts are needed to validate the optimal T/N ratio cutoff point before treatment strategies can be adjusted based on 18F-FDG PET.
JOURNAL OF NEUROIMAGING
(2021)
