Article
Computer Science, Artificial Intelligence
Mohsen Gholami, Rabab Ward, Ravneet Mahal, Maryam Mirian, Kevin Yen, Kye Won Park, Martin J. McKeown, Z. Jane Wang
Summary: In this study, an automatic, objective, and weakly supervised method was proposed for labeling gait videos of Parkinson's Disease patients. The method utilizes labeling functions and a generative model to classify patients' gait, and incorporates a weakly supervised 3D human pose estimation method to improve accuracy. The results suggest that the use of labeling functions may provide a robust means to interpret and classify patient-oriented videos involving motor tasks.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Neurosciences
Elizabeth L. Stegemoller, Andrew Zaman, Mack Shelley, Bhavana Patel, Ahmad El Kouzi, Elizabeth A. Shirtcliff
Summary: This study investigated the acute effects of group therapeutic singing on physiological and clinical motor symptoms in persons with Parkinson's disease. Results indicated that participants in the singing group reported feeling less sad after the session, with an increase in heart rate compared to the control group. This suggests that group therapeutic singing may be beneficial for persons with PD without causing undue stress.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Masahiro Nakamori, Megumi Toko, Hidetada Yamada, Yuki Hayashi, Kai Ushio, Kohei Yoshikawa, Azusa Haruta, Aya Hiraoka, Mineka Yoshikawa, Toshikazu Nagasaki, Yukio Mikami, Hirofumi Maruyama
Summary: This study aimed to investigate swallowing dysfunction in patients with PD using videofluoroscopy and the MDS-UPDRS sub-scores. The results revealed a correlation between muscle rigidity and laryngeal penetration or aspiration risk.
NEUROLOGICAL SCIENCES
(2023)
Review
Clinical Neurology
David Nascimento, Jaqueline Carmona, Tiago Mestre, Joaquim J. Ferreira, Isabel Guimaraes
Summary: This study evaluated six drooling rating scales, finding heterogeneous characteristics and incomplete reliability analysis. Among them, only the ROMP-saliva scale was classified as recommended for people with Parkinson's disease due to its substantial evidence of clinimetric properties adequacy.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Sheida Zolfaghari, Alessandra E. Thomann, Natalia Lewandowski, Dylan Trundell, Florian Lipsmeier, Gennaro Pagano, Kirsten Taylor, Ronald B. Postuma
Summary: This study explored the association between health outcomes and self-reported motor function impairment in Parkinson's disease patients compared to clinician-examined motor signs. High self-reporters reported greater impairment in patient-reported variables than low self-reporters, despite showing similar or less impairment on clinician-examined and biomarker measures. Self-reported motor impairment was also correlated with nonmotor symptoms, suggesting the need for further investigation into the assessment of motor-related impairments in Parkinson's disease.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Etienne de Villers-Sidani, Patrice Voss, Daniel Guitton, J. Miguel Cisneros-Franco, Nils A. Koch, Simon Ducharme
Summary: The idea that eye movements can reflect certain aspects of brain function and inform on the presence of neurodegeneration is not new. A novel technology using the embedded camera of a mobile tablet has been tested and shown to replicate well-known findings regarding eye movement anomalies in Parkinson's disease (PD). This tablet-based tool has the potential to accelerate eye movement research and aid in disease identification and progression monitoring in clinical settings.
FRONTIERS IN NEUROLOGY
(2023)
Article
Chemistry, Analytical
Foivos S. S. Kanellos, Konstantinos I. I. Tsamis, Georgios Rigas, Yannis V. V. Simos, Andreas P. P. Katsenos, Gerasimos Kartsakalis, Dimitrios I. I. Fotiadis, Patra Vezyraki, Dimitrios Peschos, Spyridon Konitsiotis
Summary: Parkinson's disease (PD) is the second most common neurodegenerative condition after Alzheimer's disease (AD), with high prevalence and incidence rates. Current care strategies for PD patients, involving brief appointments at outpatient clinics, have limitations in evaluating disease progression due to interpretability issues and recall bias. Artificial-intelligence-driven telehealth solutions, such as wearable devices, have the potential to improve patient care and help physicians manage PD more effectively by monitoring patients objectively in their familiar environment. This study evaluates the validity of in-office clinical assessment compared to home monitoring, and identifies the existence of an index capable of remotely measuring patients' quality of life for the first time.
Article
Clinical Neurology
Esther Cubo, Alvaro Garcia-Bustillo, Sara Calvo, Gonzalo Gamez-Leyva, Lucia Simon-Vicente, Jessica Rivadeneyra, Javier Miranda, Elisabet Madrigal, Pablo Martinez-Martin, Pablo Mir
Summary: This study aimed to identify the most sensitive items for assessing motor impairment in Parkinson's disease (PD). The results showed that postural stability and body bradykinesia were the most discriminating items in the Off state, while right and left upper extremity bradykinesia were the most discriminating items in the On state. Additionally, body bradykinesia and right-left finger tapping were the items with the largest effect size for assessing motor improvement after receiving antiparkinsonian medications.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Urs Kleinholdermann, Max Wullstein, David Pedrosa
Summary: This study aimed to develop a mobile, objective, and unobtrusive method for measuring motor symptoms in Parkinson's disease. Data from 45 PD patients were collected using surface electromyography (sEMG) electrodes attached to a wristband. A random forest regression model showed the highest correlation of 0.739 between true and predicted UPDRS values, indicating the potential of sEMG data in extrapolating motor symptoms of PD patients.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Christian Ineichen, Heide Baumann-Vogel, Matthias Sitzler, Daniel Waldvogel, Christian R. Baumann
Summary: The study found that motor symptoms worsened and motor disease progression significantly increased in patients with Parkinson's disease during pandemic-related restrictions compared to before the COVID-19 outbreak.
JOURNAL OF PARKINSONS DISEASE
(2021)
Review
Clinical Neurology
Atul Goel, Ramkumar Sugumaran, Sunil K. Narayan
Summary: Parkinson's disease is a progressive neurodegenerative disease caused by a depletion of dopamine, with limited available therapies. Zonisamide may be a potential candidate to alleviate symptoms of PD, with evidence supporting its efficacy in motor symptoms as an adjunctive therapy but lacking for non-motor symptoms, requiring further investigation.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Natalia Palacios, Anas Hannoun, Julie Flahive, Doyle Ward, Kelsey Goostrey, Anindita Deb, Kara M. Smith
Summary: In this study, the impact of Levodopa initiation on the gut microbiota of Parkinson's disease patients was investigated through a longitudinal analysis. The results did not show significant changes in microbiota composition before vs. after Levodopa initiation. There was a preliminary observation of a potential association between the abundance of Clostridium group IV and short-term motor symptom response to Levodopa, which warrants further investigation in larger, longer-term studies with control groups.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Kishoree Sangarapillai, Benjamin M. Norman, Quincy J. Almeida
Summary: The management of Parkinson's disease has been affected by COVID-19 restrictions, leading to challenges in conducting virtual assessments and potentially impacting disease management. A regression equation was developed to predict total motor symptom severity scores from partial scores, which may be useful for remote management and outreach in rural communities.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Neurosciences
Michela Barichella, Emanuele Cereda, Laura Iorio, Giovanna Pinelli, Valentina Ferri, Erica Cassani, Carlotta Bolliri, Serena Caronni, Chiara Pusani, Maria Giulia Schiaffino, Angelica Giana, Elena Quacci, Caterina Esposito, Francesca Monti Guarnieri, Aurora Colombo, Francesca Del Sorbo, Roberto Cilia, Giorgio Sacilotto, Giulio Riboldazzi, Anna Lena Zecchinelli, Gianni Pezzoli
Summary: This study found that Parkinson's disease patients have lower levels of serum 25-hydroxyvitamin D than the general population, and low levels of serum 25-hydroxyvitamin D are associated with more severe disease, worse symptoms, and greater impairment of global cognitive function.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Sabrina Poonja, Janis Miyasaki, Xilai Fu, Richard Camicioli, Tina Sang, Yan Yuan, Fang Ba
Summary: This study examined the trajectories of UPDRS-III scores in PD patients at the end of life, revealing distinct patterns of motor deterioration and identifying a subset with irregular trajectory types. Regardless of trajectory, many patients experienced a sharp increase in UPDRS-III approaching death, and younger age of disease onset correlated with shorter survival time.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, Research & Experimental
Zi H. Su, Salil Patel, Bronwyn Gavine, Tim Buchanan, Marko Bogdanovic, Nagaraja Sarangmat, Alexander L. Green, Bastiaan R. Bloem, James J. FitzGerald, Chrystalina A. Antoniades
Summary: This study compared the effects of dopaminergic medication and subthalamic nucleus deep brain stimulation (STN DBS) on gait variability in Parkinson disease patients. The results showed that STN DBS reduced short-term variability in lower limb gait parameters, while medication did not have this effect. In addition, STN DBS had no effect on arm swing and trunk motion variability, while medication increased them.
Article
Clinical Neurology
Henrieke L. Frequin, Jason Schouten, Constant V. M. Verschuur, Sven R. Suwijn, Judith A. Boel, Bart Post, Bastiaan R. Bloem, Johannes J. van Hilten, Teus van Laar, Gerrit Tissingh, Alexander G. Munts, Joke M. Dijk, Gunther Deuschl, Anthony Lang, Marcel G. W. Dijkgraaf, Rob J. de Haan, Rob M. A. de Bie
Summary: The study found that levodopa had similar effects on bradykinesia, rigidity, and tremor in patients with early Parkinson's disease. The improvements in symptoms were larger at 22 weeks compared to 4 weeks. At 80 weeks, fewer patients in the early-start group experienced motor response fluctuations.
Article
Clinical Neurology
Amir H. Talebi, Jan H. L. Ypinga, Nienke M. De Vries, Jorik Nonnekes, Marten Munneke, Bas R. Bloem, Tom Heskes, Yoav Ben-Shlomo, Sirwan K. L. Darweesh
Summary: Specialized physiotherapy and occupational therapy can reduce the incidence rate of Parkinson's disease-related complications. There may be a synergistic effect among multiple specialized allied health disciplines. The findings of this study support the introduction of specialized allied health therapy expertise in Parkinson's disease care.
MOVEMENT DISORDERS
(2023)
Editorial Material
Neurosciences
Bastiaan R. Bloem, Lorraine V. Kalia
JOURNAL OF PARKINSONS DISEASE
(2023)
Editorial Material
Clinical Neurology
Milan Beckers, Bastiaan R. Bloem, Rick C. Helmich
JOURNAL OF MOVEMENT DISORDERS
(2023)
Review
Neurosciences
Anouk Tosserams, Bastiaan R. Bloem, Kaylena Ehgoetz A. Martens, Rick C. Helmich, Roy P. C. Kessels, James M. Shine, Natasha L. Taylor, Gabriel Wainstein, Simon J. G. Lewis, Jorik Nonnekes
Summary: In stressful situations, individuals with Parkinson's disease (PD) may experience worsening of motor symptoms, including gait impairments. However, some patients report benefits from stressful or high-arousal situations. A study with 4324 PD patients shows that they use various mental strategies to cope with gait impairments, which can either increase or decrease overall sympathetic tone. This suggests that arousal can have both detrimental and alleviating effects on gait control in PD.
TRANSLATIONAL NEURODEGENERATION
(2023)
Article
Neurosciences
Martin E. Johansson, Nina M. van Lier, Roy P. C. Kessels, Bastiaan R. Bloem, Rick C. Helmich
Summary: Heterogeneity in Parkinson's disease (PD) makes it difficult to understand the disease and develop treatments. Stratifying patients into subtypes based on clinical characteristics may help overcome this challenge. A recent study classified de novo PD patients into three subtypes and found that the diffuse-malignant subtype had more severe symptoms and faster progression compared to the mild-motor predominant subtype. These findings suggest different pathophysiological mechanisms underlie distinct PD subtypes.
NPJ PARKINSONS DISEASE
(2023)
Review
Clinical Neurology
Anneli Langbroek-Amersfoort, Sabine Schootemeijer, Lars Bouten, Bastiaan R. Bloem, Nienke M. De Vries
Summary: There is increasing evidence supporting the positive effects of community-based exercise for individuals with Parkinson's disease. However, the studies on this topic vary greatly in terms of exercise types, study designs, and outcome measures. While this review acknowledges the feasibility and potential benefits of community-based exercise, it also emphasizes the need for improvement in the overall quality of these studies.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2023)
Article
Clinical Neurology
Dijana Nuic, Sjors van de Weijer, Saoussen Cherif, Anna Skrzatek, Eline Zeeboer, Claire Olivier, Jean-Christophe Corvol, Pierre Foulon, Jenica Z. Pastor, Gregoire Mercier, Brian Lau, Bastiaan R. Bloem, Nienke M. De Vries, Marie-Laure Welter
Summary: This study aimed to evaluate the efficacy of a home-based training system using a tailored exergame for patients with Parkinson's disease (PD) to improve gait and balance disorders. The results showed that home-based training using a tailored exergame can be performed safely by PD patients and could potentially improve gait and balance disorders.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Editorial Material
Neurosciences
Federica Albanese, Bastiaan R. Bloem, Lorraine V. Kalia
Summary: Metascience emphasizes the importance of replication, reproducibility, and rigor in research, particularly in studying major diseases like Parkinson's disease.
JOURNAL OF PARKINSONS DISEASE
(2023)
Review
Clinical Neurology
Carlo Alberto Artusi, Christian Geroin, Jorik Nonnekes, Camila Aquino, Divyani Garg, Marian L. Dale, Darbe Schlosser, Yijie Lai, Mohammad Al-Wardat, Mehri Salari, Robin Wolke, Valery Tsinda Labou, Gabriele Imbalzano, Serena Camozzi, Marcelo Merello, Bastiaan R. Bloem, Tamine Capato, Ruth Djaldetti, Karen Doherty, Alfonso Fasano, Houyam Tibar, Leonardo Lopiano, Nils G. Margraf, Caroline Moreau, Yoshikazu Ugawa, Roongroj Bhidayasiri, Michele Tinazzi
Summary: Axial postural abnormalities are common in patients with Parkinson's disease and atypical parkinsonism, and have a significant impact on the patients' quality of life. However, there is limited understanding of the pathophysiology and clinical predictors of these symptoms, highlighting the need for further research in this area.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Editorial Material
Clinical Neurology
Tessa F. Peerbolte, Rozanne J. A. van Diggelen, Marjan J. Meinders, Bastiaan R. Bloem, Sanne W. van den Berg
PRACTICAL NEUROLOGY
(2023)
Article
Clinical Neurology
Milan Beckers, Peter J. Koehler, Geert J. A. Wanten, Bastiaan R. Bloem
Summary: There is a hypothesis suggesting that Adolf Hitler had Parkinson's disease and suffered from gastrointestinal symptoms, possibly linked to small-intestinal bacterial overgrowth (SIBO), serving as an early indication of Parkinson's.
EUROPEAN NEUROLOGY
(2023)
Letter
Clinical Neurology
Rui Araujo, Jos J. Kole, Joaquim J. Ferreira, Bastiaan R. Bloem
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Francisco Cardoso, Christopher G. Goetz, Tiago A. Mestre, Cristina Sampaio, Charles H. Adler, Daniela Berg, Bastiaan R. Bloem, David J. Burn, Michael S. Fitts, Thomas Gasser, Christine Klein, Marina A. J. de Tijssen, Anthony E. Lang, Shen-Yang Lim, Irene Litvan, Wassilios G. Meissner, Brit Mollenhauer, Njideka Okubadejo, Michael S. Okun, Ronald B. Postuma, Per Svenningsson, Louis C. S. Tan, Taiji Tsunemi, Sarah Wahlstrom-Helgren, Oscar S. Gershanik, Victor S. C. Fung, Claudia Trenkwalder
MOVEMENT DISORDERS
(2023)