Urinary Isoprostanes in Friedreich Ataxia: Lack of Correlation with Disease Features

To assess the utility of urinary isoprostanes as markers of oxidative injury in Friedreich ataxia (FA), we compared levels of urinary F-2-isoprostanes in patients with FA and healthy control subjects. Levels of urinary F-2-isoprostanes in FA patients were not different from controls and were not significantly associated with age, GAA repeat length, disability level, or the use of antioxidants. Thus, urinary F-2-isoprostanes are not a useful biomarker in FA. (C) 2008 Movement Disorder Society