Article
Neurosciences
Peter M. Lauro, Shane Lee, Umer Akbar, Wael F. Asaad
Summary: The study discovered distinct neurophysiological characteristics of tremor onset and maintenance in Parkinson's disease. The subthalamic nucleus plays a key role in tremor onset, while control of tremor shifts to cortex in sustained tremor state. Furthermore, changes in directed functional connectivity across sensorimotor cortex distinguish the sustained tremor state.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Abteen Mostofi, Francesca Morgante, Mark J. Edwards, Peter Brown, Erlick A. C. Pereira
Summary: Pain in Parkinson's disease is often untreated due to lack of understanding of its mechanisms. Deep brain stimulation of the subthalamic nucleus has shown potential in treating pain, but the exact type of pain it benefits and how it interferes with pain processing remain unclear.
Article
Clinical Neurology
Kay Palopoli-Trojani, Stephen L. Schmidt, Karley D. Baringer, Theodore A. Slotkin, Jennifer J. Peters, Dennis A. Turner, Warren M. Grill
Summary: This study compared the effects of temporally non-regular patterns of deep brain stimulation (DBS) to traditional regularly-spaced pulses. It found that both patterns were equally effective in modulating motor symptoms, oscillatory activity, and DBS local evoked potentials (DLEPs). Additionally, one of the novel patterns allowed for longer duration DLEPs to be recorded during clinically effective stimulation.
Editorial Material
Neurosciences
Bin Xiao, Eng-King Tan
Summary: In a recent study, researchers including Zhang and Roy discovered that neurons in the parafascicular thalamus project to three distinct neural structures in the basal ganglia. These neural circuits were found to be associated with specific motor and non-motor symptoms in a Parkinson's disease mouse model. The findings offer potential therapeutic targets for the treatment of this disease.
TRENDS IN NEUROSCIENCES
(2023)
Article
Biology
Peter M. Lauro, Shane Lee, Daniel E. Amaya, David D. Liu, Umer Akbar, Wael F. Asaad
Summary: This study decodes the neural activity of patients with Parkinson's disease, revealing distinct neural signatures for tremor and bradykinesia, and demonstrating the importance of signal type and location in understanding these motor states. The results suggest the potential for utilizing neurophysiology to improve the treatment of Parkinson's disease.
Article
Neurosciences
Zhenxiang Zang, Tianbin Song, Jiping Li, Binbin Nie, Shanshan Mei, Chun Zhang, Tao Wu, Yuqing Zhang, Jie Lu
Summary: This study investigates the information flow between brain regions in patients with Parkinson's disease using noninvasive F-18-FDG-PET/functional magnetic resonance imaging (fMRI). The results show increased glucose metabolism and functional connectivity between the sensorimotor area and the subthalamic nucleus (STN) in PD patients. The metabolic connectivity mapping (MCM) approach further reveals an exaggerated cortical input to the STN in PD, supporting the precentral gyrus as a treatment target.
Article
Multidisciplinary Sciences
Verneri Ruonala, Eero Pekkonen, Olavi Airaksinen, Markku Kankaanpaa, Pasi A. Karjalainen, Saara M. Rissanen
Summary: This study explored the effects of DBS treatment on muscle activation patterns in PD patients and found that changing the DBS settings significantly affected the correlation dimension, recurrence rate, and kurtosis of the EMG signal. Increased recurrence rates were observed in comparison to the optimal settings. With optimal stimulation settings, patients' UPDRS-III score decreased by 35% on average, but there were no significant differences in arm tremor and rigidity scores.
Article
Multidisciplinary Sciences
Alexandre Boutet, Radhika Madhavan, Gavin J. B. Elias, Suresh E. Joel, Robert Gramer, Manish Ranjan, Vijayashankar Paramanandam, David Xu, Jurgen Germann, Aaron Loh, Suneil K. Kalia, Mojgan Hodaie, Bryan Li, Sreeram Prasad, Ailish Coblentz, Renato P. Munhoz, Jeffrey Ashe, Walter Kucharczyk, Alfonso Fasano, Andres M. Lozano
Summary: This study investigates the use of fMRI to predict optimal stimulation settings for Parkinson's disease patients undergoing DBS, demonstrates the establishment of a machine learning model based on fMRI patterns, and suggests that fMRI brain responses could serve as an objective biomarker for clinical response.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Tingting Du, Tianshuo Yuan, Guanyu Zhu, Ruoyu Ma, Xin Zhang, Yingchuan Chen, Jianguo Zhang
Summary: Age and disease durations have unique effects on symptom control in PD patients treated with STN-DBS.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Tianqi Hu, Hutao Xie, Yu Diao, Houyou Fan, Delong Wu, Yifei Gan, Fangang Meng, Yutong Bai, Jianguo Zhang
Summary: This study aimed to investigate the effects of STN-DBS on PD patients with different levels of depression and identify predictors of these effects. The results showed that patients with moderate depression had better improvement, and gender (female) and preoperative HAMA scores were predictors of the effects of STN-DBS on PD depression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Zheng Ye, Guanyu Zhang, Yingshuang Zhang, Shuaiqi Li, Na Liu, Xiaolin Zhou, Weizhong Xiao, Thomas F. Munte
Summary: The study aimed to investigate neural markers of sequential working memory deficits in patients with de novo Parkinson's disease, revealing that the overactivation and weakened functional connectivity of the subthalamic nucleus are the neural markers of these deficits.
MOVEMENT DISORDERS
(2021)
Article
Multidisciplinary Sciences
Fenghua Chen, Junliang Qian, Zhongkai Cao, Ang Li, Juntao Cui, Limin Shi, Junxia Xie
Summary: In this study, a decrease in the number of GABAergic neurons in the brain region of 6-hydroxydopamine-induced PD mice was found. Activation and inhibition of GABAergic neurons through chemogenetics and optogenetics significantly improved motor function in PD mice and increased dopamine content in the striatum.
Article
Neurosciences
Caroline Xie, John Power, Asheeta A. Prasad
Summary: In this study, optogenetic modulation of subthalamic nucleus (STN) neuronal activity was found to exert bidirectional control of motor function. The activation of STN in the absence of dopamine led to abnormal involuntary movement in a Parkinson's disease model, which could be rescued by levodopa administration. These findings highlight the importance of dopamine loss and STN overactivity in Parkinson's disease motor deficits and provide insight into the therapeutic mechanism of targeting the STN.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Vasiliki Bougou, Michael Vanhoyland, Thomas Decramer, Anais Van Hoylandt, Steven Smeijers, Bart Nuttin, Philippe De Vloo, Wim Vandenberghe, Alice Nieuwboer, Peter Janssen, Tom Theys
Summary: This study investigated the neural activity changes during cycling in patients with Parkinson's disease. The results showed that both active and passive cycling caused suppression of beta activity, while active cycling also led to stronger high gamma band activity. Furthermore, patients with freezing of gait exhibited stronger beta suppression during passive cycling.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Linbin Wang, Jun Li, Yixin Pan, Peng Huang, Dianyou Li, Valerie Voon
Summary: This study evaluated the subacute effect of bilateral ventral subthalamic nucleus stimulation at 10Hz on emotional processing in Parkinson's disease patients. The results showed that 10Hz stimulation increased arousal ratings in patients with higher depression scores and induced a positive shift in valence ratings to negative emotional stimuli in patients with lower apathy scores. In contrast, 130Hz stimulation led to reduced arousal ratings in all patients and more positive valence ratings in patients with higher apathy scores.