期刊
MOVEMENT DISORDERS
卷 24, 期 3, 页码 429-433出版社
WILEY
DOI: 10.1002/mds.22399
关键词
ATP13A2; Parkinson's disease; association study; Parkinsonism
资金
- Deutsche Forschungsgemeinschaft (DFG) [KU 1344/4-1]
- Federal Ministry of Education and Research, German Competence Network on Parkinson's disease [01G19901, 01GI0201, 01GI0401]
- Volkswagen Foundation to Christine Klein
A role or ATP13A2 in early-onset Parkinsonism (EOP) has been proposed. Conversely, the contribution of this ATPase to late-onset Parkinson's disease (PD) remains unexplored. We therefore conducted a case-control association study in this age-of-onset group with PD. The initial sample was of German origin and consisted of 220 patients with late-onset PD (mean age of onset 60.1. years) and 232 age-matched unrelated controls. Five single nucleotide polymorphisms (SNPs) covering ATP13A2 and its common haplotypes were genotyped. The overall association results in this sample were negative. Interestingly, gender stratification gave a positive result for SNP rs11203280 (P-UNC = 0.016) in men. This result could not be reproduced in a replication sample of German and Serbian origin composed of 161 patients with late-onset PD (mean age of onset 51.7 years) and 150 age- and ethnic-matched controls. In conclusion, we found no consistent evidence for an association between ATP13A2 and late-onset PD. (C) 2008 Movement Disorder Society
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