Article
Ophthalmology
Aaron M. Wold, Grant A. Justin, Samuel D. Hobbs, Katherine M. Baker, Derek P. Brady, James K. Aden, Denise S. Ryan, Eric D. Weichel, Marcus H. Colyer
Summary: This study characterized the nature of posterior segment ocular injuries in combat trauma, revealing that Zone II and III injuries were associated with worse visual prognosis. Closed-globe injuries showed lower risks of certain posterior segment injuries but higher risks of others compared to open-globe injuries.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Morgan M. Harvey, Grant A. Justin, Daniel I. Brooks, Denise S. Ryan, Eric D. Weichel, Marcus H. Colyer
Summary: The study found that modern combat trauma results in complex ocular injuries, leaving 30% of patients legally blind in the injured eye. It is crucial to maintain a diverse range of deployable, specialty trained ophthalmologists to ensure optimal visual outcomes for wounded warriors, and maintain mission readiness.
OPHTHALMIC EPIDEMIOLOGY
(2021)
Article
Ophthalmology
Justin P. Harris, Grant A. Justin, Daniel I. Brooks, Fasika A. Woreta, Rupesh V. Agrawal, Denise S. Ryan, Eric D. Weichel, Marcus H. Colyer
Summary: Open-globe injuries are common in combat ocular trauma, with poor final visual acuity noted most in corneo-scleral wounds, where approximately 50% of patients had a final visual acuity less than 20/200. Perforating and globe rupture injuries were found to be more likely to undergo enucleation.
ACTA OPHTHALMOLOGICA
(2021)
Review
Clinical Neurology
Paul G. Harch
Summary: This systematic review examines the evidence for hyperbaric oxygen therapy in Persistent Postconcussion Syndrome using a dose-analysis based on the scientific definition of hyperbaric oxygen therapy. The results suggest that hyperbaric oxygen therapy at 1.5 ATA can significantly improve symptoms and cognitive function in patients with mild traumatic brain injury Persistent Postconcussion Syndrome, with positive and negative results found at different doses of oxygen and pressure.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Dhananjay Radhakrishnan Subramaniam, Ginu Unnikrishnan, Aravind Sundaramurthy, Jose E. Rubio, Vivek Bhaskar Kote, Jaques Reifman
Summary: Studies on the biomechanical responses of the human brain to blast waves have highlighted the importance of including detailed information such as brain-surface convolutions, major cerebral veins, and non-linear brain-tissue properties for improving model accuracy. Inclusion of a more detailed network of cerebral veins and arteries can enhance model-predicted biomechanical responses and help identify correlates of blast-induced brain injury. The detailed cerebral vasculature model redistributed brain-tissue strains and highlighted the importance of including a detailed cerebral vessel network in human-head FE models to more comprehensively account for the biomechanical responses induced by blast exposure.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Clinical Neurology
Jennifer N. Belding, Michael Egnoto, Robyn M. Englert, Shannon Fitzmaurice, Cynthia J. Thomsen
Summary: The field of blast research suffers from inconsistencies in conceptualization and terminology, hindering interpretation and integration of study findings while increasing the likelihood of redundant efforts. To advance the research on blast exposure effects, multidisciplinary experts need a universal language and standardized terminology.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Jennifer N. Belding, Robyn M. Englert, Shannon Fitzmaurice, Jourdan R. Jackson, Hannah G. Koenig, Michael A. Hunter, Cynthia J. Thomsen, Uade Olaghere da Silva
Summary: This scoping review provides a comprehensive overview of the literature on blast exposure, with a focus on low-level blast (LLB) exposure. The findings suggest that LLB exposure may have detrimental effects on the health of both animals and humans, but the results are mixed and more research is needed. Collaboration across disciplines, larger sample sizes, and standardization of terminology, exposures, and outcomes would benefit future research in this area.
FRONTIERS IN NEUROLOGY
(2021)
Article
Immunology
Suhjung Janet Lee, Aric F. Logsdon, Mayumi Yagi, Britahny M. Baskin, Elaine. R. Peskind, Murray M. Raskind, David G. Cook, Abigail. G. Schindler
Summary: The dynorphin/KOR system may play a role in mediating biochemical and behavioral dysfunction following repetitive blast exposure, highlighting its potential as a prophylactic/therapeutic target in the future.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Orthopedics
Anais Chataigneau, Alexia Milaire, Paul-Vincent Martin, Julien Danis, Fabrice Bazile, Nicolas de l'Escalopier, Laurent Mathieu
Summary: This study evaluated the functional outcomes of hindfoot blast injuries in French service personnel, comparing amputated patients with non-amputated patients. The results showed better long-term functional outcomes in the amputated group.
INTERNATIONAL ORTHOPAEDICS
(2021)
Article
Medicine, General & Internal
Sung Ho Jang, Eun Bi Choi, Young Seo Lee
Summary: This study examined the incidence and characteristics of physical disabilities in patients with postconcussion syndrome (PCS) after a mild traumatic brain injury (mTBI). It found that approximately 5% of patients with PCS after mTBI had definite physical disabilities, with most of them showing mild quadriparesis.
Article
Immunology
Britahny M. Baskin, Aric F. Logsdon, Suhjung Janet Lee, Brian D. Foresi, Elaine Peskind, William A. Banks, David G. Cook, Abigail G. Schindler
Summary: In this study, repetitive blast trauma was induced in female and male mice using a blast overpressure model. The findings showed different behavioral, inflammatory, microbiome, and vascular dysfunction outcomes in female and male mice. However, only male mice exhibited adverse behavioral outcomes that lasted at least one month.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Clinical Neurology
Martijn de Neeling, Dirk Liessens, Bart Depreitere
Summary: Mild traumatic brain injury (mTBI) has a high incidence worldwide, and long-term persistent postconcussion symptoms (PPCS) are predicted by psychological and psychiatric factors. Anxiety, depressive symptoms, and emotional distress early after injury can predict PPCS burden and functional outcome. Coping styles, preinjury psychiatric disorders and mental health also correlate with PPCS burden and functional outcome.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Danielle D. Dang, Jason H. Boulter, Melissa R. Meister, John Dang, Geoffrey Ling, James Ecklund
Summary: NeuroTeam has played a crucial role in military medicine by providing world-class neurological care through collaboration with neurointensivists. Their innovations and adaptability have improved patient care and streamlined treatment processes on the battlefield.
NEUROSURGICAL FOCUS
(2022)
Article
Clinical Neurology
Ido Ben Zvi, Oren Shaia Harel, Amos Douvdevani, Penina Weiss, Chen Cohen, Eynat Ben Ari, Gal Gross, Yehonatan Menndel, David Felzensztein, Noa Schwartz, Shani Berkowitz, Michael Drescher, Sagi Harnof
Summary: This study suggests that circulating cell-free DNA (cfDNA) can be used as a potential biomarker for screening postconcussion syndrome (PCS) in the emergency room. The results show a correlation between cfDNA levels and cognitive performance status, indicating the potential of cfDNA as an early predictor of PCS.
JOURNAL OF NEUROSURGERY
(2022)
Article
Neurosciences
Rita Campos-Pires, Bee Eng Ong, Mariia Koziakova, Eszter Ujvari, Isobel Fuller, Charlotte Boyles, Valerie Sun, Andy Ko, Daniel Pap, Matthew Lee, Lauren Gomes, Kate Gallagher, Peter F. Mahoney, Robert Dickinson
Summary: This study investigates the effects of repeated mild blast traumatic brain injury (mbTBI) on rats and identifies specific brain regions that are particularly sensitive to repeated blast exposure. The findings suggest that repeated exposure to blast can lead to functional impairments and neuronal loss in certain brain regions. The reasons for this sensitivity may include exposure to stronger shockwaves or proximity to tissue density transitions. This study provides insights into the mechanisms of injury sensitization and potential new treatments.