Article
Biochemistry & Molecular Biology
Wenxiao Du, Xuedong Wang, Lin Wang, Mingyong Wang, Chao Liu
Summary: Avermectin concentration has lethal effects on the development of zebrafish heart, causing malformation abnormalities, changes in heart rate, and reduction in hatching rate and body length. Transcriptome analysis revealed alterations in signal pathways related to cardiac circulation and myocardial fiber development. Avermectin primarily targets the heart and affects its development and function through the modulation of cardiac-related gene expression.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Environmental Sciences
Keyuan Zhong, Yunlong Meng, Juan Wu, You Wei, Yong Huang, Jinze Ma, Huiqiang Lu
Summary: The study revealed that flupyradifurone has toxic effects on zebrafish embryos, leading to decreased survival rate, heart rate, and body length, as well as abnormal heart development and increased oxidative stress levels. Moreover, flupyradifurone also affects the expression of genes related to apoptosis and heart development. The findings provide new evidence on the toxic effects of flupyradifurone and the potential risks associated with its residues in agricultural products and the environment.
ENVIRONMENTAL POLLUTION
(2021)
Article
Pharmacology & Pharmacy
Mahima Sharma, V. N. K. Godlaveti, S. Prajapati, A. Kumar, A. Tripathi, P. Gupta
Summary: Atropa belladonna, a highly toxic plant, is used in homeopathy to treat various health conditions. This study evaluated the embryonic toxicity of belladonna mother tincture using zebrafish embryos, showing that higher concentrations may cause developmental malformations while 1% concentration affects locomotor behavior.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Ana C. Quevedo, Iseult Lynch, Eugenia Valsami-Jones
Summary: Cell death is a crucial process in maintaining cell homeostasis, and silver nanoparticles (AgNPs) have been shown to induce cell death by disrupting cellular signaling functions. This study used embryonic zebrafish cells as a model to investigate the mechanisms involved in AgNPs and Ag+ toxicity, with different sizes and concentrations of AgNPs and Ag+ being tested. The results indicated that exposure dose and physicochemical properties of AgNPs played a significant role in regulating various cell death modalities and signaling pathways in response to induced damage.
Article
Environmental Sciences
Yuanzhao Wu, Jiawen Wang, Yumei Xia, Kaiqin Tang, Jincheng Xu, Anli Wang, Shundi Hu, Luhong Wen, Binjie Wang, Weixuan Yao, Jiye Wang
Summary: This study demonstrated the developmental and neurotoxic effects of Isofenphos-methyl (IFP) on zebrafish embryos. IFP exposure resulted in abnormal heart development, uninflated swim bladder, and behavioral defects. Furthermore, IFP exposure activated oxidative stress and reduced acetylcholinesterase (AChE) content.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Lu Dai, Juanjuan Luo, Meilan Feng, Maya Wang, Jiannan Zhang, Xiaoqian Cao, Xiaojun Yang, Juan Li
Summary: The accumulation and adverse effects of nanoplastics (NPs) are a growing concern for the environment and human health. This study used the zebrafish model to investigate the developmental toxicity of nanoplastics exposure. The results showed that nanoplastics exposure caused developmental defects in zebrafish embryos, including morphological deformities and vascular malformation.
Article
Biochemistry & Molecular Biology
Venugopalan Rajesh, Annadurai Kokilavani, Subramanian Jayaseelan, Swaminathan Gomathi, Korrapati Vishali, Manni Venkatachari Kumudhavalli
Summary: Approximately 7.9 million children worldwide are born with serious birth defects, and prenatal exposure to drugs and environmental toxicants plays a significant role in these malformations. This study focused on investigating the effect of acetyl-L-carnitine (AC) in mitigating cardiac malformation caused by valproic acid (VPA) in developing zebrafish. The results showed that AC significantly reduced the severity of VPA-induced cardiac malformation.
Article
Environmental Sciences
Peng Xiao, Wenhua Li, Jinfang Lu, Yang Liu, Qiulan Luo, He Zhang
Summary: The study found that Bixafen has toxic effects on the retinal development of zebrafish embryos, leading to severe retinal defects and increased cell density in the ganglion cell layer.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Yolina Yu Lin Wang, Yan-Er Cai, Syed Shabi Ul Hassan Kazmi, Jing Yang, Yuwen Wang, Ping Li, Wenhua Liu, Zhen Wang
Summary: The widespread agricultural use of neonicotinoids poses a threat to non-target organisms. However, existing toxicity data for these pesticides does not consider the influence of environmental factors such as temperature. This study assessed the temperature-dependent toxicity of six neonicotinoids, finding that temperature had an inverted V-shaped relationship with toxicity. The results provide valuable information for evaluating the effects and mechanisms of neonicotinoids, particularly in the context of climate change.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Environmental Sciences
Yunlong Meng, Keyuan Zhong, Suping Chen, Yong Huang, You Wei, Juan Wu, Juan Liu, Zhaopeng Xu, Jing Guo, Fasheng Liu, Huiqiang Lu
Summary: The study revealed that exposure to Pendimethalin can reduce heart rate, survival rate, and body length of zebrafish embryos, causing various malformations and affecting antioxidant enzyme activity and the expression of genes related to cardiac development.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Ruiqi Fan, Wanjun Zhang, Lizhong Li, Li Jia, Jun Zhao, Zengming Zhao, Shuangqing Peng, Xiaoyan Yuan, Yiqiang Chen
Summary: The fungicide carbendazim and insecticide chlorpyrifos, used together to protect fruit and vegetable crops in China, have potentially harmful effects on zebrafish embryonic development, both individually and in combination, showing significant synergistic effects. These findings suggest the need for health and environmental risk assessments for various combinations of these agents.
Article
Environmental Sciences
Yi Liu, Jing Guo, Fengjie Yang, Yunyun Deng, Yuyang Peng, Yunlong Meng, Wenjin Liu, Bo Cheng, Jianping Fu, June Zhang, Xinjun Liao, Huiqiang Lu
Summary: The study showed that chlorobromoisocyanuric acid induced immune cell reduction, thymus shrinkage, upregulation of pro-inflammatory response, and oxidative stress in zebrafish. However, the antioxidant astaxanthin could significantly alleviate these toxic effects.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Mingrui Yuan, Wenhua Li, Peng Xiao
Summary: In this study, exposure to BIX was found to induce cardiac toxicity in zebrafish embryos, leading to cardiac dysplasia and dysfunction. This toxicity was associated with decreased expression of erythropoiesis-related and cardiac development-related genes in response to BIX treatment. These findings highlight the potential environmental risks of BIX exposure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Food Science & Technology
Ruiqi Fan, Wanjun Zhang, Li Jia, Lizhong Li, Jun Zhao, Zengming Zhao, Shuangqing Peng, Yiqiang Chen, Xiaoyan Yuan
Summary: The study found that Difenoconazole (DIF) and dimethomorph (DIM) had negative effects on the development of embryonic zebrafish, especially showing synergistic deleterious effects on deformity and mortality rates. Transcriptome analysis revealed that these compounds may disrupt DNA replication and cell cycle progression by downregulating certain genes. Enhanced surveillance is recommended for this pesticide combination due to the potentially more harmful effects of simultaneous environmental exposure.
Article
Environmental Sciences
Pottanthara Ashokan Anila, Jesudass Sutha, Devaraj Nataraj, Mathan Ramesh
Summary: The study investigated the concentration-specific toxicity of nano-Pd in zebrafish, revealing that high doses of nano-Pd had negative effects on the hatching rate, embryo survival, heartbeat, and acetylcholinesterase activity in larvae, while long-term exposure resulted in erratic movements and altered antioxidant enzyme activity in adult fish. Additionally, nano-Pd induced histopathological lesions in gill, liver, and brain, indicating oxidative stress and providing insights into the fate and toxicity of nano-Pd in the aquatic environment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Multidisciplinary Sciences
Ruanni Chen, Irum Mukhtar, Shurong Wei, Siyi Wu, Jianming Chen
Summary: This study used Ophryotrocha xiamen as an experimental model to investigate the early regeneration process. Through detailed morphological and molecular analyses, the changes in gene expression and morphology during early regeneration were revealed. The study identified 243 differentially expressed genes involved in metabolism and signal transduction, and 8 distinct fragments of Hox genes. These findings contribute to a better understanding of the functions of genes involved in regeneration processes and offer important insights into developmental biology in marine invertebrates.
SCIENTIFIC REPORTS
(2022)
Article
Oceanography
Konglin Zhou, Yuping Gu, Lu Wang, Jianming Chen
Summary: This study confirms a new species of Cladonema, named Cladonema multiramosum sp. nov., discovered in a laboratory aquarium in Fuzhou, China, through morphological and molecular analyses. The distinctive features of the Cladonema multiramosum sp. nov. medusa differentiate it from other congeners, although the species also exhibits significant phenotypic plasticity, hindering species identification solely based on morphology. Therefore, a re-evaluation of the taxonomy within the genus Cladonema is necessary, with further revision expected based on additional information on the life cycle and DNA barcoding.
ACTA OCEANOLOGICA SINICA
(2022)
Article
Fisheries
Wei Wang, Jinlin Chen, Chen Yu, Changkun Pan, ZhenYue Lin, Jianming Chen
Summary: Sodium-coupled monocarboxylate transporter 1 (SMCT1) plays a crucial role in the transmembrane transfer of monocarboxylate substrates in cells and also acts as a tumor suppressor in various tissues. This study demonstrates the significance of SMCT1 in the innate immune response against viral pathogens in Drosophila and Penaeus vannamei (whiteleg shrimp).
Article
Environmental Sciences
Xiangjuan Ma, Cong He, Yan Yan, Jianming Chen, Huajun Feng, Jinfei Hu, Hang Zhu, Yijing Xia
Summary: In this study, a novel Ti-foam/PbO2-GN composite electrode was successfully fabricated and applied for environment-friendly antibiotic wastewater treatment. The Ti-foam/PbO2-GN electrode exhibited a more compact surface structure, smaller crystal grain size, and greater electrochemical active surface area compared to traditional electrodes, leading to improved treatment efficiency. Moreover, the electrode demonstrated excellent stability, repeatability, and safety, ensuring environmental protection.
Article
Ecology
Zhenyue Lin, Xinqing Zheng, Jianming Chen
Summary: This study investigates the response of the coral microbiome to oceanic pH changes caused by anthropogenic climate change. The results show that both ocean acidification and alkalization disrupt the functional cores of the microbiome, affecting the carbon cycling and health of the coral holobiont. While bacterial species richness does not vary significantly among pH treatments, the community compositions show significant differences. Seawater alkalization leads to a stronger taxonomic shift and an increase in pathogens compared to acidification. The study highlights the importance of understanding the functional ecological role of the microbiome in coral resilience.
Article
Ecology
Guiping Ye, Jianming Chen, Ping Yang, Hang-Wei Hu, Zi-Yang He, Dan Wang, Dingding Cao, Wenbin Zhang, Bingyu Wu, Yonghong Wu, Xiangying Wei, Yongxin Lin
Summary: This study found that non-native species invasion can increase fungal diversity and the relative abundance of saprotrophic and pathogenic fungi in coastal wetlands. It also showed that deterministic processes play a stronger role in fungal community assembly in non-native species compared to native species.
Article
Plant Sciences
Zhenyue Lin, Wei Wang, Jianming Chen
Article
Virology
Qin Zheng, Wei Wang, Furong Zhao, Shen Lin, Jianming Chen
Summary: The study focused on the characterization of a protein called CQIV-168L in Cherax quadricarinatus iridovirus (CQIV). The protein was found to be expressed late during infection, localized in the cytoplasm and associated with virus factories. It was also identified as a component of the viral envelope.
Article
Immunology
Zongliang Huang, Wei Wang, Pengpeng Xu, Shangyu Gong, Yingshan Hu, Yan Liu, Fang Su, Khalid Mahmood Anjum, Wu-Min Deng, Suping Yang, Jiyong Liu, Renjie Jiao, Jianming Chen
Summary: In this study, it was found that the adaptor protein Ect4 of the Toll pathway contributes to resistance to viral infection and regulates the JAK/STAT signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Jianfang Huang, Mingcan Zhou, Jianming Chen, Caihuan Ke
Summary: The Haliotis discus hannai is an economically important species in China, but slow growth and small size have caused losses to farmers. Molecular genetic manipulation is the most effective way to breed high-quality abalone with rapid growth rates. This study revealed that the myostatin gene played a critical role in the growth regulation of H. discus hannai and provided a reference for mollusk breeding using molecular markers for growth traits.
Article
Fisheries
Li Wang, Anlan Yu, Cong Yu, Umar Bashir Ibrahim, Jianming Chen, Yan Wang
Summary: Two feeding trials were conducted to evaluate the influence of dietary curcumin level on fish meal replacement with poultry by-product (PBM) in a largemouth bass (Micropterus salmoides) diet. The results showed that the replacement of fish meal with PBM significantly affected feed intake, phosphorus retention efficiency (PRE), body lipid content, the ratio of fish meal consumption to fish production (RCP), and carbon and phosphorus wastes. However, weight gain, feed conversion ratio (FCR), nitrogen and energy retention efficiencies (NRE and ERE), and body composition remained unchanged. Overall, the minimum dietary fish meal level for largemouth bass could be dropped to 80 g/kg when PBM was used as an alternative ingredient, and 10000 mg/kg curcumin could obviously improve the growth of fish fed diet containing 80 g/kg fish meal.
AQUACULTURE RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Muhua Wang, Lingwei Ruan, Meng Liu, Zixuan Liu, Jian He, Long Zhang, Yuanyuan Wang, Hong Shi, Mingliang Chen, Feng Yang, Runying Zeng, Jianguo He, Changjun Guo, Jianming Chen
Summary: This study analyzed the genome of Ridgeia piscesae, a deep-sea tubeworm species, and found unique adaptations and evolutionary mechanisms compared to other deep-sea organisms.
Article
Microbiology
Xiaoli Lei, Xiaojuan Chen, Jianming Chen, Chen Liang
Summary: In this study, a new species of naked amoeba, Mayorella marianaensis sp. n., was described. It was isolated from the deep ocean (>3,000 m depth) near the Mariana Trench, and identified based on morphological and molecular data. Mayorella marianaensis is an irregularly rectangular naked amoeba with a narrow frontal hyaline area, distinctive sub-pseudopodia, and three forms of floating forms. Phylogenetic analysis revealed its classification into Dermamoebida and its relationship with other Mayorella species. BLAST analysis showed its closest similarities to Coronamoeba villafranca and Mayorella sp. JJP-2003.
Article
Fisheries
Jinlin Chen, Wei Wang, Qin Zheng, Yunying Cheng, Qian Zhang, Shenfei Jiang, Jianming Chen
Summary: In this study, DIV1 detection methods were developed using a variable antigen receptor (vNAR) derived from shark heavy-chain antibodies. The lead vNAR, D02, was identified to target the viral antigen ORF064L. Indirect ELISA and dot-blot assays were developed based on D02 vNAR, demonstrating high sensitivity and specificity compared to qRT-PCR. This is the first study to develop a vNAR against DIV1, providing a robust tool for its diagnosis.
AQUACULTURE REPORTS
(2023)
Article
Environmental Sciences
Zhenyue Lin, Liuying Wang, Mingyu Luo, Xiaofeng Yi, Jianming Chen, Yuanpeng Wang
Summary: This study investigated the potential effects of zero-valent iron (ZVI) on the interactions between soil arsenic migration and methane emission using a bioelectrochemical system. The results showed that ZVI efficiently immobilized dissolved arsenic and increased methane production. Gene quantification and bacterial community analysis revealed that ZVI changed the spatial distribution of electroactive microorganisms, leading to a decrease in dissimilatory As/Fe-reducing bacteria and an increase in aceticlastic methanogens, which dominated methane production and arsenic immobilization. Additionally, coprecipitation with ferric iron contributed a significant portion of the dissolved arsenic.
