Article
Critical Care Medicine
Beomsu Shin, Jin Young Lee, Yunjoo Im, Hongseok Yoo, Junseon Park, Joo Sang Lee, Ki-Young Lee, Kyeongman Jeon
Summary: This study examined the differential expression of exosomal miRNAs in plasma samples from sepsis patients and healthy controls. Four downregulated miRNAs (hsa-let-7f-5p, miR-331-3p, miR-301a-3p, and miR-335-5p) were identified as independent prognostic factors for in-hospital and 90-day mortalities among sepsis patients. Bioinformatics analysis suggested that these miRNAs may contribute to sepsis pathogenesis through PI3K-Akt and MAPK signaling pathway.
JOURNAL OF INTENSIVE CARE
(2023)
Review
Biochemistry & Molecular Biology
Sekyung Oh, Sang-Ho Kwon
Summary: This article discusses the challenges of diagnosing acute kidney injury (AKI) and the discovery and application of EVs as biomarkers, as well as the importance of EVs for treating AKI. Future research will focus on addressing the shortcomings of current EV-based AKI diagnosis and therapeutic applications, with the aim of bringing more innovation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Jing Wang, Junwen Wang, Xinyan Li, Kai Shu
Summary: Traumatic brain injury (TBI) is a complex and life-threatening condition with no effective treatment to date. Exosomes (Exos), particularly those derived from cells, have the potential to deliver drugs to target lesions in the brain by crossing the blood-brain barrier. Moreover, Exos-derived microRNAs show promise as biomarkers for TBI. This review examines the potential impact of cell-derived Exos and exosome-derived microRNAs on the diagnosis, therapy, and prognosis prediction of TBI.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Yan Zhao, Xiaolu Li, Wenbo Zhang, Lanlan Yu, Yang Wang, Zhun Deng, Mingwei Liu, Shanshan Mo, Ruonan Wang, Jinming Zhao, Shuli Liu, Yun Hao, Xiangdong Wang, Tianjiao Ji, Luo Zhang, Chenxuan Wang
Summary: EVs play important roles in biomedical applications, acting as efficient drug-delivery carriers and participating in disease diagnosis and treatment. Investigating the origins and working mechanisms of EVs can provide insights into life activities and disease development.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Biology
Maria Chiara Ciferri, Rodolfo Quarto, Roberta Tasso
Summary: Extracellular vesicles (EVs) are membrane-bound vesicles released by all cell types, playing a crucial role in intercellular communication and serving as biomarkers for various diseases. EVs isolated from stem/progenitor cells exhibit innate immunosuppressive and anti-inflammatory properties, making them potential vehicles for drug delivery.
Review
Biochemistry & Molecular Biology
Yu-Chen Jia, Yi-Xuan Ding, Wen-Tong Mei, Yu-Ting Wang, Zhi Zheng, Yuan-Xu Qu, Kuo Liang, Jia Li, Feng Cao, Fei Li
Summary: Comprehensive reviews and large population-based cohort studies have significantly reduced the incidence and mortality of pancreatitis. The study of extracellular vesicles (EVs), especially exosomes, in pancreatitis has shown potential for identifying cell-to-cell communication and influencing the disease's development and progression. Plasma exosomes of acute pancreatitis can reach the alveolar cavity and activate alveolar macrophages to cause acute lung injury, suggesting their use as biomarkers and therapeutic agents for this disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Biology
Chanbin Lee, Jinsol Han, Youngmi Jung
Summary: Extracellular vesicles (EVs) are membrane-bound nanoparticles that are released by cells and carry various cargoes, such as proteins and nucleic acids, to recipient cells. In chronic liver disease, the production and secretion of EVs are increased, and the cargoes carried by EVs are altered, exacerbating inflammation, fibrosis, and angiogenesis. Understanding the role of EVs and their cargoes in liver disease is important for its treatment.
Review
Oncology
Jose Pedro Sequeira, Vera Constancio, Joao Lobo, Rui Henrique, Carmen Jeronimo
Summary: Liquid biopsies have emerged as a new tool for early diagnosis, with circulating or exosome miRNAs showing great potential in renal cell carcinoma. The study of these miRNAs in liquid biopsies has experienced exponential growth, signaling a promising development in clinical applications.
Review
Biochemistry & Molecular Biology
Nada Basheir Ali, Ahmad Faizal Abdull Razis, Der Jiun Ooi, Kim Wei Chan, Norsharina Ismail, Jhi Biau Foo
Summary: This article introduces the role and applications of extracellular vesicles (EVs), including their function as signaling molecules between cells, as well as their advantages as non-invasive diagnostic tools and drug carriers. It also discusses the latest research findings on plant-derived EVs.
Article
Engineering, Biomedical
Christopher Millan, Lukas Prause, Queralt Vallmajo-Martin, Natalie Hensky, Daniel Eberli
Summary: Engineered microtissues have a significant impact on extracellular vesicles (EVs) secreted by benign and malignant prostate cells, with a higher yield of EVs per cell in 3D cultures compared to 2D. Whole transcriptome sequencing and proteomics analysis reveal stark contrasts in molecular cargo between 2D-EVs and 3D-EVs, with exclusive enrichment of known drivers of prostate cancer progression in 3D-EVs. Functional assays demonstrate that only 3D-EVs confer increased invasiveness and chemoresistance to cells in 2D, highlighting the potential of engineered 3D microtissue cultures for identifying biomarkers not detectable in standard 2D conditions.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Biomedical
Badrinathan Sridharan, Hae Gyun Lim
Summary: Biomaterials and their formulations have been successful in diagnostic and therapeutic applications, but there are limitations in terms of yield and target specificity. Some nano/microformulations can respond to physical or chemical alterations. This review discusses the applications of exosomes and ultrasound in disease diagnosis and therapy, as well as the potential of ultrasound to enhance the properties of exosomes for future theranostics.
MATERIALS TODAY BIO
(2023)
Article
Cardiac & Cardiovascular Systems
Susmita Sahoo, Marta Adamiak, Prabhu Mathiyalagan, Franziska Kenneweg, Sabine Kafert-Kasting, Thomas Thum
Summary: Exosomes are small membrane-bound vesicles actively secreted by cells. Research on the potential and challenges of exosomes in biological signaling in myocardial function highlights their significance in cardiac physiology and pathology, emphasizing the need for scientific innovations in isolation and characterization methodologies.
Review
Chemistry, Multidisciplinary
Jagannath Mondal, Shameer Pillarisetti, Vijayabhaskarreddy Junnuthula, Monochura Saha, Seung Rim Hwang, In-kyu Park, Yong-kyu Lee
Summary: Exosomes are natural nanocarriers secreted by cells, which can be modified to load additional cargo for expanded biomedical applications. They have the potential to overcome the limitations of conventional nanoparticle-based techniques in targeted therapy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Oncology
Ilaria Casari, Justin Andrew Howard, Eunice Eugenia Robless, Marco Falasca
Summary: Pancreatic cancer, as one of the most lethal types of cancer, is difficult to diagnose and treat in time. The appearance of metastasis is dreaded by every cancer patient.
Review
Biochemistry & Molecular Biology
Katarzyna Horodecka, Markus Duchler
Summary: The establishment of CRISPR/Cas9 technology has revolutionized gene editing and therapeutic interventions, but challenges remain in effectively delivering components to living organisms. Utilizing extracellular vesicles as delivery devices may help overcome limitations and improve the clinical applications of this technology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
