Article
Endocrinology & Metabolism
Yujin Ding, Guangdi Li, Zhiguang Zhou, Tuo Deng
Summary: Diabetes and hepatitis C are two distinct diseases, but they are closely related, as hepatitis C virus infection may lead to diabetes and influence the occurrence and development of diabetes through multiple mechanisms.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Virology
Yujiao He, Maolin Huang, Chunyan Tang, Yan Yue, Xiao Liu, Zhebin Zheng, Hongbo Dong, Deming Liu
Summary: MicroRNA-122 plays a critical role in HCV replication, and daidzein inhibits HCV replication by decreasing miR-122 levels, enhancing the antiviral effect of IFN-?, without significantly affecting cell growth.
Article
Biochemistry & Molecular Biology
Marzieh Jamalidoust, Maryam Shafaati, Mehdi Kalani, Maryam Zare, Mazyar Ziyeayan
Summary: The study demonstrates the inhibitory effect of let-7b on HCV replication by promoting apoptosis and reducing HCV-RNA load. Therefore, let-7b may serve as a potential antiviral therapy target.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Genetics & Heredity
Amin Ullah, Irshad Ur Rehman, Katharina Ommer, Nadeem Ahmed, Margarete Odenthal, Xiaojie Yu, Jamshaid Ahmad, Tariq Nadeem, Qurban Ali, Bashir Ahmad
Summary: This study evaluated the expression profile of circulating miR-192 and 29a and found that they were significantly upregulated in patients with chronic HCV infection, suggesting their potential as biomarkers for hepatic disease.
Review
Gastroenterology & Hepatology
Alessandra Mangia, Rosa Cotugno, Giovanna Cocomazzi, Maria Maddalena Squillante, Valeria Piazzolla
Summary: The World Health Organization's goal of eliminating Hepatitis C virus (HCV) by 2030 using direct-acting antiviral treatments has become less attainable post the 2020 pandemic of coronavirus disease 2019. Therefore, a more realistic approach of micro-elimination in population segments where targeted strategies of prevention and treatment are easily attained has been promoted in Europe. Active involvement of stakeholders and community participation are essential components for the success of a micro-elimination project tailored at the geographical level according to HCV epidemiology and individual country's income.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Hirohito Yoneyama, Asahiro Morishita, Hisakazu Iwama, Koji Fujita, Takahiro Masaki, Joji Tani, Tomoko Tadokoro, Takako Nomura, Teppei Sakamoto, Kyoko Oura, Kei Takuma, Mai Nakahara, Shima Mimura, Akihiro Deguchi, Makoto Oryu, Kunihiko Tsutsui, Takashi Himoto, Kunitada Shimotohno, Takaji Wakita, Hideki Kobara, Tsutomu Masaki
Summary: The study found that hsa-miR-762 may be one of the host factors involved in the exclusion of HCV through DAA therapy. Its expression quantiles significantly increased when HCV was eradicated, and decreased in cases of treatment failure.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biophysics
Ru Cheng, Fu Zhu, Min Huang, Qiang Zhang, Hui Hong Yan, Xiao Hui Zhao, Fu Kang Luo, Chun Mei Li, Hui Liu, Gao Lin Liang, Cheng Zhi Huang, Jian Wang
Summary: In this study, a new biosensor named hepatitis virus indicator was developed for the simultaneous detection of HBV and HCV. The biosensor utilized Exo III assisted signal amplification strategy and particle counting technology with a dark-field microscopy, enabling sensitive and selective detection.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Microbiology
Tsai-Ling Liao, Yi-Ming Chen, Shie-Liang Hsieh, Kuo-Tung Tang, Der-Yuan Chen, Ying-Ying Yang, Hung-Jen Liu, Sheng-Shun Yang
Summary: This study investigates the roles of BAFF and exosomal miRNAs in the extrahepatic manifestations of HCV infection, revealing an association between HCV-infected hepatocyte-derived miRNAs and host TLR7 genetic background with BAFF expression. The findings suggest a potential mechanism for HCV infection-related autoimmunity and provide insights into the development of extrahepatic diseases, offering a possible target for treatment.
Article
Immunology
Xijing Qian, Bingan Wu, Chen Xu, Zhongtian Qi
Summary: The study identified dysregulated miRNAs in HCV-infected cells, with miR-4423-3p shown to promote HCV infection by suppressing the RIG-I/IFN pathway. The research provides insights into the miRNA regulatory networks in HCV infection and progression, offering promising avenues for novel therapeutic and diagnostic targets.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Christelle Granier, Johan Toesca, Chloe Mialon, Maureen Ritter, Natalia Freitas, Bertrand Boson, Eve-Isabelle Pecheur, Francois-Loic Cosset, Solene Denolly
Summary: Hepatitis C virus (HCV) particles are stable when secreted from cells, but become highly unstable after freeze-thawing of producer cells. Cell-secreted proteins can protect HCV particles from degradation, specifically those that are lipidated and low-density. HCV particles are sensitive to oxidation, but can be protected from lipid oxidation by secreted factors.
Article
Medicine, General & Internal
Renata Krupa, Wojciech Malecki, Piotr Czarny, Justyna Strycharz, Maciej Jablkowski, Radzislaw Kordek, Janusz Szemraj, Tomasz Sliwinski
Summary: The study investigated the potential of miRNAs regulating genes involved in iron homeostasis as diagnostic or prognostic factors for HCV-related hepatocellular carcinoma. It found that miRNA expression profiles were altered in HCC patients, with some miRNAs showing potential as diagnostic factors by correlating with iron metabolism proteins.ROC curve analyses showed that 15 miRNAs could effectively discriminate between HCC patients and healthy controls, with higher sensitivity and specificity than alpha-fetoprotein.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Gastroenterology & Hepatology
Po-Yao Hsu, Yu-Ju Wei, Po-Cheng Liang, Jia-Jung Lee, Sheng-Wen Niu, Jiun-Chi Huang, Cheng-Ting Hsu, Tyng-Yuan Jang, Ching- Huang, Yi-Hung Lin, Ming-Yen Hsieh, Meng-Hsuan Hsieh, Szu-Chia Chen, Chia-Yen Dai, Zu-Yau Lin, Shinn-Cherng Chen, Jee-Fu Huang, Jer-Ming Chang, Ming-Lun Yeh, Chung-Feng Huang, Yi-Wen Chiu, Shang-Jyh Hwang, Wan-Long Chuang, Ming-Lung Yu
Summary: Hemodialysis patients are at increased risk of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. This study found that hemodialysis patients with HCV exhibited a higher burden of comorbidities, especially in ischemic heart diseases, respiratory disorders, and mental/behavioral disorders, compared to patients with HBV and those without viral hepatitis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Editorial Material
Virology
Syeda Kanza Kazmi, Fatima Muhammad Asad Khan, Valentino Natoli, Reem Hunain, Zarmina Islam, Ana Carla dos Santos Costa, Shoaib Ahmad, Mohammad Yasir Essar
Summary: Hepatitis is a significant cause of mortality worldwide, with around 1.34 million deaths annually. Africa is not immune to this issue, with an estimated 100 million individuals infected with Hepatitis B or C. The continent, already fragile, is further burdened by the onset of the COVID-19 pandemic, which could potentially worsen the threat from viral diseases like Hepatitis. Strengthening prevention policies is essential for Africa to build resilience against such threats.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Immunology
Wen Hou, Xiaoli Wu
Summary: This study investigates the roles of gamma delta T cells in HBV and HCV infections, discussing the different roles they play in the progression of liver diseases at various stages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Shih-Han Hung, Tzong-Hann Yang, Yen-Fu Cheng, Chin-Shyan Chen, Herng-Ching Lin
Summary: This case-control study investigates the associations between head and neck cancer (HNC), hepatitis B virus (HBV), and hepatitis C virus (HCV) infection, and suggests a potential association between HBV and HCV infections and the risk of HNC.
Correction
Virology
Tammy Doukas, Peter Sarnow
JOURNAL OF VIROLOGY
(2017)
Article
Multidisciplinary Sciences
Sujata Jha, Madeline G. Rollins, Gabriele Fuchs, Dean J. Procter, Elizabeth A. Hall, Kira Cozzolino, Peter Sarnow, Jeffrey N. Savas, Derek Walsh
Meeting Abstract
Oncology
Hak Kyun Kim, Gabriele Fuchs, Shengchun Wang, Wei Wei, Yue Zhang, Hyesuk Park, Biswajoy Roy-Chaudhuri, Pan Li, Jianpeng Xu, Kirk Chu, Feijie Zhang, Mei-sze Chua, Samuel So, Cliff Zhang, Peter Sarnow, Mark A. Kay
Article
Microbiology
Miguel Mata, Steven Neben, Karim Majzoub, Jan Carette, Muthukumar Ramanathan, Paul A. Khavari, Peter Sarnow
Article
Microbiology
Yaw Shin Ooi, Karim Majzoub, Ryan A. Flynn, Miguel A. Mata, Jonathan Diep, Jason Kenichi Li, Nicholas van Buuren, Neil Rumachik, Alex G. Johnson, Andreas S. Puschnik, Caleb D. Marceau, Luwanika Mlera, Jeffrey M. Grabowski, Karla Kirkegaard, Marshall E. Bloom, Peter Sarnow, Carolyn R. Bertozzi, Jan E. Carette
NATURE MICROBIOLOGY
(2019)
Article
Microbiology
Jonathan Diep, Yaw Shin Ooi, Alex W. Wilkinson, Christine E. Peters, Eileen Foy, Jeffrey R. Johnson, James Zengel, Siyuan Ding, Kuo-Feng Weng, Orly Laufman, Gwendolyn Jang, Jiewei Xu, Tracy Young, Erik Verschueren, Kristi J. Kobluk, Joshua E. Elias, Peter Sarnow, Harry B. Greenberg, Ruth Huttenhain, Claude M. Nagamine, Raul Andino, Nevan J. Krogan, Or Gozani, Jan E. Carette
NATURE MICROBIOLOGY
(2019)
Article
Microbiology
Tzu-Chun Chen, Marc Tallo-Parra, Qian M. Cao, Sebastian Kadener, Rene Bottcher, Gemma Perez-Vilaro, Pakpoom Boonchuen, Kunlaya Somboonwiwat, Juana Diez, Peter Sarnow
Review
Microbiology
Shwetha Shivaprasad, Peter Sarnow
Summary: This review article focuses on how pathogenic RNA viruses utilize host biochemical machineries and specific RNA elements in the untranslated regions to achieve viral infection cycles and enhance viral fitness.
CURRENT OPINION IN MICROBIOLOGY
(2021)
Editorial Material
Parasitology
Shwetha Shivaprasad, Peter Sarnow
Summary: Mosquitoes can acquire human microRNA hsa-miR-150-5p during blood meals and use it to protect the Dengue virus by downregulating chymotrypsin AaCT-1 mRNA. This finding suggests the potential use of microRNA antagomirs as an antiviral approach in mosquitoes.
TRENDS IN PARASITOLOGY
(2022)
Article
Microbiology
Shwetha Shivaprasad, Kuo-Feng Weng, Yaw Shin Ooi, Julia Belk, Jan E. Carette, Ryan Flynn, Peter Sarnow
Summary: Using a novel RNA-protein detection assay, researchers discovered that Sec61A1 and Loqs have pro-viral functions in dengue viral infections in mosquito cells. Specifically, Loqs forms complexes with the positive-strand of the viral RNA and the very 3' end of the negative-strand viral RNA. Further analysis showed that Loqs modulates viral RNA replication of dengue virus and gene amplification of several other flaviviral genomes. These findings suggest that Loqs is an essential pro-viral host factor in mosquitos.
Editorial Material
Multidisciplinary Sciences
Qian M. Cao, Peter Sarnow
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Kuo-Feng Weng, Han Kang Tee, Eirini D. Tseligka, Valeria Cagno, Gregory Mathez, Stephane Rosset, Claude M. Nagamine, Peter Sarnow, Karla Kirkegaard, Caroline Tapparel
Summary: This study found that a variant of the EV-A71 virus has increased ability to cause intestinal lesions and increased susceptibility to neutralizing antibodies. However, a double mutant with even greater ability to cause intestinal lesions is not pathogenic, possibly due to its stronger binding affinity to heparin sulfate, which traps the virus in peripheral tissues and reduces its ability to invade the nervous system.
Article
Multidisciplinary Sciences
Jessica L. Diaz, Verl B. Siththanandan, Victoria Lu, Nicole Gonzalez-Nava, Lincoln Pasquina, Jessica L. MacDonald, Mollie B. Woodworth, Abdulkadir Ozkan, Ramesh Nair, Zihuai He, Vibhu Sahni, Peter Sarnow, Theo D. Palmer, Jeffrey D. Macklis, Suzanne Tharin
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Review
Microbiology
Sarah R. Gonzales-van Horn, Peter Samow
CELL HOST & MICROBE
(2017)
Meeting Abstract
Clinical Neurology
Verl Siththanandan, Jessica Diaz, Victoria Lu, Nicole Gonzalez-Nava, Lincoln Pasquina, Jessica MacDonald, Mollie Woodworth, Vibhu Sahni, Peter Sarnow, Theo Palmer, Jeffrey Macklis, Suzanne Tharin
ANNALS OF NEUROLOGY
(2018)