Review
Immunology
Fang Liang, Weixiao Qin, Yilan Zeng, Dan Wang
Summary: Autoimmune diseases and autoinflammatory diseases are two types of immune system disorders, and pyroptosis plays a crucial role in these diseases. Gasdermins, a pore-forming protein mainly expressed in immune cells, gastrointestinal tract, and skin, are considered as the executors of pyroptosis and have various functions and pathological effects such as pro-inflammatory responses, immune activation, and tumor mediation. Recent studies have demonstrated the significant role of gasdermins in autoimmune diseases, autoinflammatory diseases, and immune-related neoplastic diseases, making them potential therapeutic targets for immune disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Dimitri Bulte, Chiara Rigamonti, Alessandro Romano, Alessandra Mortellaro
Summary: Inflammasome complexes and their receptor proteins play crucial roles in regulating innate immune response and inflammation. However, their abnormal activation and gene mutations contribute to the development of human autoimmune and autoinflammatory diseases. In the past decade, significant progress has been made in understanding inflammasome biology and activation mechanisms. This overview provides up-to-date information on various inflammasomes, their mechanisms, and their involvement in common diseases.
Review
Cardiac & Cardiovascular Systems
Xinzhe Chen, Peng-Chao Tian, Kai Wang, Man Wang, Kun Wang
Summary: Cardiovascular disease (CVD) is a common and serious health threat. Different forms of cardiomyocyte death, including apoptosis, necrosis, and pyroptosis, play important roles in the pathogenesis of CVD. Controlling cardiomyocyte pyroptosis holds promise for the treatment of cardiovascular disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Microbiology
Abosede Salami, Sahana Bettadapura, Shanzhi Wang
Summary: This review examines the role of gasdermin D (GSDMD) in host immune defense against bacteria. While GSDMD contributes to the clearance of some bacteria, its presence may hinder effective immunity against other pathogens, aiding their invasion and spread.
MICROBIOLOGICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Shaoqiang Wei, Min Feng, Shidong Zhang
Summary: Pyroptosis is an active and ordered form of programmed cell death, signaling pathways are divided into canonical and noncanonical pathways. It plays an important role in the normal function of the immune system, but can lead to immune disorders in pathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Lexi Li, Huifeng Fan, Jinyu Zhou, Xuehua Xu, Diyuan Yang, Minhao Wu, Can Cao, Gen Lu
Summary: This study revealed that noncanonical inflammasome-related genes were upregulated in adenovirus pneumonia, and their expression levels were positively correlated with clinical parameters of inflammatory damage. In vitro experiments showed that HAdV infection triggered noncanonical inflammasome activation and macrophage pyroptosis through the NF-kB pathway, and silencing these genes inhibited inflammasome activation and macrophage pyroptosis while reducing virus release. These findings provide new insights into the pathogenesis of HAdV-induced inflammatory damage.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Aoife P. Smith, Emma M. Creagh
Summary: This review discusses the association between inflammatory caspase activity and inflammatory bowel disease (IBD) in both human and murine models. Caspases-4/-5/-11 show increased expression during IBD and are implicated in chronic inflammation. The review also explores the differences in expression and functions of caspases-4, -5, and -11, as well as their activation, function, and regulation mechanisms, and how these mechanisms may contribute to the pathogenesis of IBD.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Ruixuan You, Xinglan He, Zhuotong Zeng, Yi Zhan, Yangfan Xiao, Rong Xiao
Summary: Autoimmune diseases are a group of heterogeneous diseases caused by the destruction of immune tolerance and the production of autoantibodies. Excessive exacerbation of pyroptosis, a form of programmed cell death, plays a crucial role in the development of autoimmune diseases. Inflammasomes act as switches for pyroptosis, and various pyroptosis pathways disrupt immune system homeostasis and promote autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Oonagh Paerewijck, Mohamed Lamkanfi
Summary: Two decades of research on inflammasomes have provided extensive knowledge on their regulatory mechanisms and pathological roles, particularly in rodent models. Recent progress in the field has focused on human-specific inflammasomes and their activation mechanisms, as well as their potential involvement in auto-inflammatory, metabolic, and neoplastic diseases. Clinical trials and translational efforts for developing inflammasome-targeted therapies have shown promising results.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Review
Virology
Zheng Wang, Haolin Yu, Wenyue Zhuang, Jingxuan Chen, Yi Jiang, Zhicheng Guo, Xiaotian Huang, Qiong Liu
Summary: Cell pyroptosis plays a crucial role in viral infections, particularly in some picornavirus infections. However, excessive inflammasome activation or pyroptosis may harm the host's health or worsen disease progression.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Chemistry, Multidisciplinary
Fan Yang, Sahana N. Bettadapura, Mark S. Smeltzer, Hua Zhu, Shanzhi Wang
Summary: This review discusses the roles of the gasdermin protein family in anti-cancer functions and various antitumor drugs that could activate the pyroptosis pathways.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Sebastian A. Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P. Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien-Hsiung Yu, Natasha Silke, Stephanie A. Conos, Daniel Frank, Daniel S. Simpson, James M. Murphy, Kate E. Lawlor, Jaclyn S. Pearson, John Silke, Marc Pellegrini, Marco Herold, Ivan K. H. Poon, Seth L. Masters, Mingsong Li, Qin Tang, Yuxia Zhang, Maryam Rashidi, Lanlan Geng, James E. Vince
Summary: This study reveals that genetic mutations in X-linked inhibitor of apoptosis (XIAP) can lead to cell death-associated inflammatory diseases. The findings show that patients with XIAP deficiency-associated inflammatory bowel disease have increased inflammatory IL-1 beta maturation and cell death-associated caspase-8 and Gasdermin D (GSDMD) processing, which can be reduced by patient treatment.
Article
Immunology
Zhongtai Wang, Xinyu Yang, Xiangyu Wang, Fang Liang, Yiting Tang
Summary: This study found that glycyrrhizin can block cytosolic delivery of LPS mediated by HMGB1, thereby attenuating the inflammatory response, coagulopathy, organ injury, and death caused by endotoxemia and sepsis. This finding suggests that pharmacological inhibition of cytosolic delivery of LPS may be a potential therapeutic strategy for treating sepsis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jun-Hyuk Han, Jooho Park, Tae-Bong Kang, Kwang-Ho Lee
Summary: Initially classified as an apoptotic caspase, caspase-8 has now been found to play significant roles in regulating inflammatory processes. Recent research has shown its involvement in modulating inflammatory responses, inflammasome activation, cell death, and cytokine induction. This review summarizes the latest advances in understanding how caspase-8 impacts inflammatory reactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Wenjing Sun, Hongquan Lu, Shujuan Dong, Rui Li, Yingjie Chu, Nan Wang, Yu Zhao, Yabin Zhang, Limeiting Wang, Lin Sun, Di Lu
Summary: This study confirmed the regulatory role of beclin1 in controlling caspase-4 mediated pyroptosis and suggested beclin-1 signaling as a potential therapeutic target in myocardial reperfusion-induced microvascular injury.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Multidisciplinary Sciences
Hanne Van Gorp, Pedro H. V. Saavedra, Nathalia M. de Vasconcelos, Nina Van Opdenbosch, Lieselotte Vande Walle, Magdalena Matusiak, Giusi Prencipe, Antonella Insalaco, Filip Van Hauwermeiren, Dieter Demon, Delfien J. Bogaert, Melissa Dullaers, Elfride De Baere, Tino Hochepied, Joke Dehoorne, Karim Y. Vermaelen, Filomeen Haerynck, Fabrizio De Benedetti, Mohamed Lamkanfi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Editorial Material
Multidisciplinary Sciences
Pedro H. V. Saavedra, Mohamed Lamkanfi
Article
Cell Biology
Nina Van Opdenbosch, Hanne Van Gorp, Maarten Verdonckt, Pedro H. V. Saavedra, Nathalia M. de Vasconcelos, Amanda Goncalves, Lieselotte Vande Walle, Dieter Demon, Magdalena Matusiak, Filip Van Hauwermeiren, Jinke D'Hont, Tino Hochepied, Stefan Krautwald, Thirumala-Devi Kanneganti, Mohamed Lamkanfi
Article
Immunology
Apurva Kanneganti, R. K. Subbarao Malireddi, Pedro H. V. Saavedra, Lieselotte Vande Walle, Hanne Van Gorp, Hiroto Kambara, Heather Tillman, Peter Vogel, Hongbo R. Luo, Ramnik J. Xavier, Hongbo Chi, Mohamed Lamkanfi
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Article
Multidisciplinary Sciences
Pedro H. Saavedra, Linyan Huang, Farzaneh Ghazavi, Stephanie Kourula, Tom Vanden Berghe, Nozomi Takahashi, Peter Vandenabeele, Mohamed Lamkanfi
NATURE COMMUNICATIONS
(2018)
Article
Biophysics
Andre Correa Amaral, Pedro H. Saavedra, Ana Camila Oliveira Souza, Maryanne Trafani de Melo, Antonio Claudio Tedesco, Paulo Cesar Morais, Maria Sueli Soares Felipe, Anamelia Lorenzetti Bocca
COLLOIDS AND SURFACES B-BIOINTERFACES
(2019)
Article
Biochemistry & Molecular Biology
Lieselotte Vande Walle, Irma B. Stowe, Pavel Sacha, Bettina L. Lee, Dieter Demon, Amelie Fossoul, Filip Van Hauwermeiren, Pedro H. Saavedra, Petr Simon, Vladimir Subrt, Libor Kostka, Craig E. Stivala, Victoria C. Pham, Steven T. Staben, Sayumi Yamazoe, Jan Konvalinka, Nobuhiko Kayagaki, Mohamed Lamkanfi
Article
Rheumatology
Hanne Van Gorp, Linyan Huang, Pedro Saavedra, Marnik Vuylsteke, Tomoko Asaoka, Giusi Prencipe, Antonella Insalaco, Benson Ogunjimi, Jerold Jeyaratnam, Ilaria Cataldo, Peggy Jacques, Karim Vermaelen, Melissa Dullaers, Rik Joos, Vito Sabato, Alessandro Stella, Joost Frenkel, Fabrizio De Benedetti, Joke Dehoorne, Filomeen Haerynck, Giuseppe Calamita, Piero Portincasa, Mohamed Lamkanfi
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Article
Cell Biology
Pedro Henrique Burgel, Clara Luna Marina, Pedro H. V. Saavedra, Patricia Albuquerque, Stephan Alberto Machado de Oliveira, Paulo Henrique de Holanda Veloso Janior, Raffael Araujo de Castro, Heino M. Heyman, Carolina Coelho, Radames J. B. Cordero, Arturo Casadevall, Joshua D. Nosanchuk, Ernesto S. Nakayasu, Robin C. May, Aldo Henrique Tavares, Anamelia Lorenzetti Bocca
MEDIATORS OF INFLAMMATION
(2020)
Article
Oncology
Mate Kiss, Lieselotte Vande Walle, Pedro H. Saavedra, Els Lebegge, Helena Van Damme, Aleksandar Murgaski, Junbin Qian, Manuel Ehling, Samantha Pretto, Evangelia Bolli, Jiri Keirsse, Pauline M. R. Bardet, Sana M. Arnouk, Yvon Elkrim, Maryse Schmoetten, Jan Brughmans, Ayla Debraekeleer, Amelie Fossoul, Louis Boon, Geert Raes, Geert van Loo, Diether Lambrechts, Massimiliano Mazzone, Alain Beschin, Andy Wullaert, Mohamed Lamkanfi, Jo A. Van Ginderachter, Damya Laoui
Summary: IL-1β plays a crucial role in promoting tumor progression and establishing an immunosuppressive microenvironment. The release of IL-1β may not necessarily require inflammasome activation. The crosstalk between CD8(+) T cells and macrophages is essential for anti-tumor immune response.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Microbiology
Oceane Dufies, Anne Doye, Johan Courjon, Cedric Torre, Gregory Michel, Celine Loubatier, Arnaud Jacquel, Paul Chaintreuil, Alissa Majoor, Rodolphe R. Guinamard, Alexandre Gallerand, Pedro H. V. Saavedra, Els Verhoeyen, Amaury Rey, Sandrine Marchetti, Raymond Ruimy, Dorota Czerucka, Mohamed Lamkanfi, Benedicte F. Py, Patrick Munro, Orane Visvikis, Laurent Boyer
Summary: Inflammasomes are critical signalling platforms assembled in response to infection or sterile inflammation, with NLRP3 playing a key role in activating the inflammasome. The activation of NLRP3 inflammasome is tightly controlled both transcriptionally and post-translationally, but the mechanisms regulating its activation remain poorly understood.
NATURE MICROBIOLOGY
(2021)
Review
Immunology
Giulia Zago, Pedro H. V. Saavedra, Kayvan R. Keshari, Justin S. A. Perry
Summary: The metabolic state of tissue-resident macrophages directly influences their function, studying metabolic requirements is crucial for understanding their identity, response to inflammatory challenges, and execution of homeostatic functions. Emerging technologies are driving in situ study of tissue-resident macrophage metabolism.
FRONTIERS IN IMMUNOLOGY
(2021)