期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 45, 期 -, 页码 59-67出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2015.10.021
关键词
Sex reversal; Gonadal development; WNT4; R-spondin1; Beta-catenin; FOXL2; CBX2; Differences/disorders of sex development
资金
- Agence Nationale de la Recherche [ANR-13-BSV2-0017-02 ARGONADS, ANR-11-LABX-0028-01]
- Fondation ARC pour la Recherche sur le Cancer [PJA 20131200236]
- Swiss National Science Foundation [320030_160334]
- Swiss National Science Foundation (SNF) [320030_160334] Funding Source: Swiss National Science Foundation (SNF)
The idea that the female sexual development happens by default was born in the middle of the last century after Jost carried out his innovative experiments to study the bases of differentiation of the reproductive tract, and found that the female reproductive tract develops even in the absence of any gonad. The term default (passive) attributed to the whole female developmental pathway therefore established itself, even if it was not originally so intended. However, recent developments have demonstrated that ovarian development is an active process. WNT4, one of a few factors with a demonstrated function in the ovarian-determination pathway, has been found to be involved in sexual differentiation by suppressing male sexual differentiation, promoting Mullerian ducts differentiation and maintaining oocyte health. WNT4 expression in the ovary seems to be regulated by R-spondin 1 (RSPO1), a thrombospondin family member protein. The role and interactions of WNT4, RSPO1 and other factors, such as FOXL2 as well as the possible role of chromatin modifiers such as the polycomb protein CBX2 in ovarian development and function will be discussed. (C) 2015 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据