期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 39, 期 -, 页码 20-25出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2015.01.006
关键词
Apoptosis; Cancer; TRAIL; Caspase-8
资金
- Deutsche Forschungsgemeinschaft
- IUAP
- BMBF
Apoptosis is a form of programmed cell death that plays a critical role in the regulation of various physiological and pathophysiological processes. Since apoptosis is typically disturbed in human cancers, therapeutic targeting of apoptosis represents a promising avenue for the development of novel therapeutic approaches. This strategy is particularly relevant, since many currently used anticancer therapies utilize apoptosis signaling pathways to exert their antitumor activities. A better understanding of these signaling networks and their deregulation in human cancers is anticipated to open new perspectives for the development of apoptosis-targeted therapies for the treatment of cancer. (C) 2015 Elsevier Ltd. All rights reserved.
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