期刊
SEMINARS IN CANCER BIOLOGY
卷 33, 期 -, 页码 57-66出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2015.03.003
关键词
Apoptosis; Cancer; Cell death; ER stress; UPR
类别
资金
- Irish Research Council [RCS1350, RCS999]
- Science Foundation Ireland [06/RFP/BIC002]
- Belgian Grant - Interuniversity Attraction Poles [IAP 7/32]
- Institut National du Cancer (INCa)
- Ligue Contre le Cancer
Cancer cells are exposed to intrinsic (oncogene) or extrinsic (microenvironmental) challenges, leading to activation of stress response pathways. The unfolded protein response (UPR) is the cellular response to endoplasmic reticulum (ER) stress and plays a pivotal role in tumor development. Depending on ER stress intensity and duration, the UPR is either pro-survival to preserve ER homeostasis or pro-death if the stress cannot be resolved. On one hand, the adaptive arm of the UPR is essential for cancer cells to survive the harsh conditions they are facing, and on the other hand, cancer cells have evolved mechanisms to bypass ER stress-induced cell death, thereby conferring them with a selective advantage for malignant transformation. Therefore, the mechanisms involved in the balance between survival and death outcomes of the UPR may be exploited as therapeutic tools to treat cancer. (C) 2015 Elsevier Ltd. All rights reserved.
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