Article
Medicine, Research & Experimental
Na Zhang, Min Cui, Xudong Liu, Lingzhi Yu, Xu Zhao, Luning Cao, Yuanyuan Ji
Summary: Osteoimmunology focuses on interactions between the skeletal and immune systems, with IL-17F playing a role in bone regeneration. IL-17F was found to promote osteoblast proliferation, differentiation, and mineralization through the MAPK/ERK1/2-mediated signaling pathway, indicating its potential as a therapeutic target for bone loss diseases.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yizeng Fan, Tao Hou, Weichao Dan, Yasheng Zhu, Bo Liu, Yi Wei, Zixi Wang, Yang Gao, Jin Zeng, Lei Li
Summary: The gene encoding SPOP is frequently mutated in prostate cancer (PCa). This study reveals that SPOP functions as a tumor suppressor by degrading PrLZ, a prostate-specific and androgen-responsive gene. ERK1/2 regulates SPOP-mediated PrLZ degradation through phosphorylation, while IL-6 acts as an upstream regulator of PrLZ degradation by promoting its phosphorylation.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sitong Hu, Yihui Zhu, Shujia Yu, Yanchuan Guo, Yihu Wang, Menghao Lv, Wei Bai, Pan Ma
Summary: The study aimed to investigate the effect of IL-10 on the phenotype polarization of macrophages and osteogenesis in T2DM rat jaw defects. The results showed that IL-10 can stably induce macrophages to M2 type and improve bone regeneration in jaw defects.
Review
Biochemistry & Molecular Biology
Richard M. Lucas, Lin Luo, Jennifer L. Stow
Summary: This article summarizes the important role of ERK1/2 in cell signaling, particularly in immune responses in immune cells. Additionally, it discusses the dysfunctional signaling of ERK1/2 in inflammatory diseases and explores the potential therapeutic benefits of targeting this pathway in inflammation.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2022)
Article
Microbiology
Jingjuan Hu, Fan Deng, Bingcheng Zhao, Zebin Lin, Qishun Sun, Xiao Yang, Mei Wu, Shida Qiu, Yu Chen, Zhengzheng Yan, Sidan Luo, Jin Zhao, Weifeng Liu, Cai Li, Ke Xuan Liu
Summary: This study investigated the relationship between the gut microbiome and intestinal ischemia/reperfusion (I/R) injury. It found that Lactobacillus murinus can alleviate intestinal I/R injury in mice through macrophages, and this effect may be achieved by promoting the release of IL-10 from macrophages through TLR2. This study revealed a novel mechanism of intestinal I/R injury and provided a new therapeutic strategy for clinical practice.
Article
Immunology
Masashi Kanayama, Yuta Izumi, Megumi Akiyama, Toyoki Hayashi, Koji Atarashi, Axel Roers, Taku Sato, Toshiaki Ohteki
Summary: Emergency myelopoiesis is a hematopoietic response against systemic infections, but the role of lymphocytes in this process has not received much attention. This study found that a unique B cell subset expressing myeloid markers emerged in the bone marrow during emergency myelopoiesis, and these cells preferentially expressed IL-10, which stimulated hematopoietic progenitors for enhanced myeloid differentiation. Blocking IL-10 significantly suppressed emergency myelopoiesis and hindered microbial clearance in a model of cecal ligation and puncture. These findings suggest the importance of adaptive immune cells in boosting emergency myelopoiesis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Surgery
Hongyu Zhang, Ruochen Li, Yifan Cao, Yun Gu, Chao Lin, Xin Liu, Kunpeng Lv, Xudong He, Hanji Fang, Kaifeng Jin, Yuchao Fei, Yifan Chen, Jieti Wang, Hao Liu, He Li, Heng Zhang, Hongyong He, Weijuan Zhang
Summary: This study revealed the clinical significance of IL-10(+) tumor-associated macrophages (TAMs) in gastric cancer. It showed that high IL-10(+) TAM infiltration was associated with poor prognosis and inferior therapeutic responsiveness to fluorouracil-based adjuvant chemotherapy. IL-10(+) TAMs drove an immunoevasive tumor microenvironment, indicating their potential as a target for immunotherapeutic approach in gastric cancer.
Article
Multidisciplinary Sciences
Jennifer K. Dowling, Remsha Afzal, Linden J. Gearing, Mariana P. Cervantes-Silva, Stephanie Annett, Gavin M. Davis, Chiara De Santi, Nadine Assmann, Katja Dettmer, Daniel J. Gough, Glenn R. Bantug, Fidinny Hamid, Frances K. Nally, Conor P. Duffy, Aoife L. Gorman, Alex M. Liddicoat, Ed C. Lavelle, Christoph Hess, Peter J. Oefner, David K. Finlay, Gavin P. Davey, Tracy Robson, Annie M. Curtis, Paul J. Hertzog, Bryan R. G. Williams, Claire E. McCoy
Summary: The study reveals that Arg2 is a protein in inflammatory macrophages regulated by miR-155 and IL-10, crucial for IL-10-induced modulation of mitochondrial dynamics and oxidative respiration. Arg2 mediates this process by increasing the activity of complex II and is essential for IL-10-mediated downregulation of inflammatory mediators.
NATURE COMMUNICATIONS
(2021)
Article
Gastroenterology & Hepatology
Ding-Jia-Cheng Jia, Qi-Wen Wang, Ying-Ying Hu, Jia-Min He, Qi-Wei Ge, Ya-Dong Qi, Lu-Yi Chen, Ying Zhang, Li-Na Fan, Yi-Feng Lin, Yong Sun, Yao Jiang, Lan Wang, Yan-Fei Fang, Hui-Qin He, Xiong-E Pi, Wei Liu, Shu-Jie Chen, Liang-Jing Wang
Summary: This study identified Lactobacillus johnsonii as a potential anti-inflammatory bacterium that can alleviate ulcerative colitis by increasing the proportion of intestinal macrophages and the secretion of Il-10. The activation of CD206(+) macrophages(IL-10) by L. johnsonii was mediated through the TLR1/2-STAT3 pathway. Clinically, there was a positive correlation between the abundance of L. johnsonii and the expression level of MRC1, IL10 and TLR1/2 in UC tissues.
Article
Chemistry, Applied
Chuencheewit Thongsiri, Yoshie Nagai-Yoshioka, Ryota Yamasaki, Yoshiyuki Adachi, Michihiko Usui, Keisuke Nakashima, Tatsuji Nishihara, Wataru Ariyoshi
Summary: During this study, the biological effect of Schizophyllan, a beta-glucan from Schizophyllum commune, on IL-10 expression in murine macrophages was investigated. It was found that SPG enhances IL-10 expression by prolonging the nuclear translocation activity of the NF-kappa B alpha pathway induced by LPS, and by stimulating phosphorylation of MSK1 and CREB, thus promoting an anti-inflammatory response in murine macrophages.
CARBOHYDRATE POLYMERS
(2021)
Article
Medicine, Research & Experimental
Jessica E. Miller, Harshavardhan Lingegowda, Lindsey K. Symons, Olga Bougie, Steven L. Young, Bruce A. Lessey, Madhuri Koti, Chandrakant Tayade
Summary: The study found that IL-33 contributes to the expansion of ILC2s in both humans and murine models, regulating the microenvironment of endometriosis lesions, and driving severe endometriosis symptoms such as inflammation, lesion proliferation, and fibrosis. IL-33 neutralization shows promise as a potential novel therapeutic avenue for treating the debilitating symptoms of endometriosis.
Review
Neurosciences
Hashim Islam, Helena Neudorf, Alice L. Mui, Jonathan P. Little
Summary: Interpreting changes in circulating cytokine concentrations as evidence for altered inflammation may overlook important functional changes in cytokine action at the tissue/cellular level, due to factors influencing cytokine function. Therefore, relying solely on changes in cytokine concentrations may miss significant alterations in inflammatory processes.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Review
Biochemistry & Molecular Biology
Ana Martin-Vega, Melanie H. Cobb
Summary: The RAS-ERK pathway is crucial for various biological processes and its aberrant activation is implicated in diseases such as cancer. This review focuses on the structure, activation, regulation, and mutational frequency of the pathway, with an emphasis on ERK1/2. The significance of scaffold proteins in kinase localization and interaction dynamics is highlighted, along with potential therapeutic approaches in this field.
Article
Cell Biology
Daofeng You, Qiuge Qiao, Katsushige Ono, Mei Wei, Wenyun Tan, Cuihua Wang, Yangong Liu, Gang Liu, Mingqi Zheng
Summary: This study reveals that miR-223-3p plays a negative regulatory role in inflammatory responses in atherosclerosis, possibly through the MEK1/ERK1/2 signaling pathway. MiR-223-3p can alleviate the formation of atherosclerotic plaques and reduce the number of inflammatory cells, providing new therapeutic prospects for the treatment of atherosclerosis.
Article
Biochemistry & Molecular Biology
Huijeong Ahn, Gilyoung Lee, Byung-Cheol Han, Seung-Ho Lee, Geun-Shik Lee
Summary: This study found that maltol can inhibit the activation of inflammasomes, thus reducing inflammation. By inhibiting ROS production and Casp1 activity, maltol exerts its anti-inflammatory effects.
Article
Biochemistry & Molecular Biology
Mai Thi Nguyen, Kyung-Ho Min, Dough Kim, Seung-Yoon Park, Wan Lee
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Mai Thi Nguyen, Kyung-Ho Min, Wan Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Mai Thi Nguyen, Kyung-Ho Min, Wan Lee
Summary: This study revealed the critical role of miR-429-3p in myogenic differentiation by suppressing CFL2, providing implications of SFA-induced miRNA in regulating actin dynamics and skeletal myogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mai Thi Nguyen, Wan Lee
Summary: This study investigated the role of miR-320-3p in myogenic progenitor cell differentiation and found that miR-320-3p mediates muscle wasting by inhibiting CFL2 expression, activating YAP1, and suppressing myoblast differentiation. These findings provide important insights into muscle myogenesis and maintenance of muscle quality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Mai Thi Nguyen, Wan Lee
Summary: The study reveals that miR-325-3p inhibits CFL2 expression, affecting F-actin regulation and causing impaired myogenic differentiation. This indicates a potential important role for miR-325-3p in the regulation of myogenesis.
Article
Biochemistry & Molecular Biology
Mai Thi Nguyen, You Han Won, Tae Won Kwon, Wan Lee
Summary: This study reveals the significant role of TWF1 in the proliferation and differentiation of C2C12 myoblasts, affecting cell fate by regulating the expression of F-actin and YAP. Knockdown of TWF1 hinders myoblast differentiation and myotube formation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Mai Thi Nguyen, Kyung-Ho Min, Wan Lee
Summary: This study reveals that excessive intake of saturated fatty acids (SFA) can lead to obesity and insulin resistance. The induction of miR-183-5p by SFA impairs insulin signaling, leading to the development of hepatic insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Mai Thi Nguyen, Wan Lee
Summary: Kank1 is a critical regulator of actin dynamics and cell proliferation in muscle progenitor cells, with its depletion impairing myogenic differentiation by promoting myoblast proliferation through F-actin-induced YAP1 nuclear translocation.
Editorial Material
Biochemistry & Molecular Biology
Wan Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mai Thi Nguyen, Wan Lee
Summary: This study showed that miR-302a affects proliferation and myogenic differentiation of myoblasts by inhibiting TWF1 expression. Palmitic acid, the most prevalent saturated fatty acid in the diet, decreased TWF1 expression and increased miR-302a levels in myoblasts. MiR-302a directly targeted the 3' UTR of TWF1 to suppress its expression. Furthermore, ectopic expression of miR-302a promoted cell cycle progression and proliferation by increasing F-actin accumulation and facilitating YAP1 nuclear translocation. This study demonstrated that miR-302a suppresses myoblast differentiation by inhibiting myogenic factor expression through TWF1 and promoting myoblast proliferation via F-actin-mediated YAP1 activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Mai Thi Nguyen, Wan Lee
Summary: This study investigated the role of miR-665-3p in regulating TWF1 expression and myogenic differentiation in progenitor cells. It was found that palmitic acid, a prevalent saturated fatty acid, suppressed TWF1 expression, inhibited myogenic differentiation, and increased miR-665-3p expression. MiR-665-3p targeted TWF1 3'UTR directly to inhibit its expression, promoting cell proliferation and progression through the F-actin/YAP1 axis.
Review
Cell Biology
Mai Thi Nguyen, Raju Dash, Kyuho Jeong, Wan Lee
Summary: Maintenance of skeletal muscle quantity and quality is crucial for various vital functions. Actin-binding proteins (ABPs) play vital roles in skeletal muscle health and diseases by regulating actin cytoskeletal dynamics. Additionally, non-coding RNAs (ncRNAs) targeting ABPs also have implications in skeletal muscle development and disorders. Understanding the functions of ABPs and the regulation by ncRNAs provides valuable insights for potential therapeutic targets in skeletal muscle disorders.
Article
Biochemistry & Molecular Biology
Mai Thi Nguyen, Wan Lee
Summary: This study investigates the functional significance and mechanism of miR-141-3p in myogenic differentiation. The results reveal that miR-141-3p directly targets and suppresses CFL2 expression, leading to altered F-actin dynamics and enhanced YAP activity in mechanotransduction. Additionally, miR-141-3p promotes myoblast proliferation and cell cycle progression, but inhibits the expression of myogenic factors and impedes myogenic differentiation.
Article
Biochemistry & Molecular Biology
Mai Thi Nguyen, Kyung-Ho Min, Wan Lee
Article
Pharmacology & Pharmacy
Kyung-Ho Min, Wan Lee
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2019)