Review
Neurosciences
Iryna Kamienieva, Jerzy Duszynski, Joanna Szczepanowska
Summary: The familial form of Parkinson's disease is linked to mutations in specific genes, with mutations in the parkin gene being one of the most common causes of early-onset PD. Mitochondrial dysfunction is an emerging active player in the pathology of neurodegenerative diseases, as mitochondria are highly dynamic structures integrated with many cellular functions.
TRANSLATIONAL NEURODEGENERATION
(2021)
Article
Biochemistry & Molecular Biology
Iryna Kamienieva, Agata Charzynska, Jerzy Duszynski, Dominika Malinska, Joanna Szczepanowska
Summary: Most cases of Parkinson's disease are idiopathic and their causes are unknown. However, a small percentage of cases are caused by genetic mutations, with the parkin gene mutation being the most common. Mitochondrial dysfunction is believed to play a role in both idiopathic and genetic Parkinson's disease. However, different studies have reported inconsistent data on mitochondrial changes, which may be due to the genetic variability of the disease. This study investigates the mitochondrial function and dynamics in fibroblasts from Parkinson's disease patients with parkin mutations. Cluster analysis of the data revealed characteristic features of Parkinson's disease fibroblasts, including smaller and less complex mitochondrial networks, as well as decreased levels of mitochondrial biogenesis regulators and mitophagy mediators.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Chi-Jing Choong, Hideki Mochizuki, Cesar Borlongan
Summary: Mitochondrial dysregulation is strongly associated with the pathogenesis of Parkinson's disease (PD), with mutated genes affecting mitochondrial features. Disruption of mitochondrial quality control and abnormal secretion of mitochondrial contents play a role in PD, and circulating mitochondrial DNAs can elicit inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Tohru Kitada, Mustafa T. Ardah, M. Emdadul Haque
Summary: Parkin, discovered 25 years ago as the gene responsible for hereditary Parkinson's disease, remains a subject of intense research interest. Despite extensive efforts, the function and mechanism of the Parkin protein in neuronal cell death and pathogenesis remain unknown. This review highlights the chronological research on the parkin gene and discusses unresolved issues, new trends in research, and the relationship between parkin and tumorigenesis from the perspective of Parkin's redox molecule.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Zhongting Zhao, Zheng Li, Fangning Du, Yixin Wang, Yue Wu, Kah-leong Lim, Lin Li, Naidi Yang, Changmin Yu, Chengwu Zhang
Summary: Parkinson's disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Misfolding, aggregation, and abnormal degradation of proteins are believed to be key factors in the pathogenesis of PD. Heat shock protein 70 (Hsp70) and Parkin, an E3 ubiquitin ligase, have been found to play important roles in PD pathogenesis. This review focuses on the dysregulation of Hsp70 and Parkin, their interaction, and their potential therapeutic applications in PD.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Li Wang, Yu-fang Yang, Long Chen, Zhu-qing He, Dian-yong Bi, Lei Zhang, Yan-wu Xu, Jian-cheng He
Summary: Compound Dihuang Granule (CDG) is used in traditional Chinese medicine to treat Parkinson's disease (PD) by suppressing the JNK/AP-1 signaling pathway and thus inhibiting apoptosis in the nigrostriatal pathway, alleviating PD symptoms.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Alexander V. Blagov, Andrey G. Goncharov, Olga O. Babich, Viktoriya V. Larina, Alexander N. Orekhov, Alexandra A. Melnichenko
Summary: This review discusses the use of mitophagy activators as a class of drug compounds for the treatment of Parkinson's disease, and explores the impact of mutations in Pink1 and Parkin enzymes on mitophagy.
Article
Biochemistry & Molecular Biology
Yu-Ling Hsu, Huey-Shan Hung, Chia-Wen Tsai, Shih-Ping Liu, Yu-Ting Chiang, Yun-Hua Kuo, Woei-Cherng Shyu, Shinn-Zong Lin, Ru-Huei Fu
Summary: Parkinson's disease is a degenerative disease that causes motor, cognitive, and behavioral disorders. The extract peiminine from Fritillaria thunbergii Miq has antioxidant and anti-neuroinflammatory effects, showing neuroprotective potential in PD models by reducing oxidative stress and cell degeneration and enhancing autophagy. Additionally, peiminine reduces the accumulation of alpha-synuclein, suggesting it as a promising candidate for further evaluation in PD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Collin M. Bantle, Warren D. Hirst, Andreas Weihofen, Evgeny Shlevkov
Summary: Mitochondrial dysfunction is a key feature of Parkinson's disease, impacting the functions of astrocytes in the brain. Important astrocytic functions rely on healthy mitochondria, presenting new challenges for therapeutic development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Clinical Neurology
Yi-Min Sun, Hui-Ling Yu, Xin-Yue Zhou, Wei-Xi Xiong, Su-Shan Luo, Chen Chen, Feng-Tao Liu, Jue Zhao, Yi-Lin Tang, Xiao-Niu Liang, Yu-Jie Yang, Bo Shen, Yan Shen, Wen-Bo Yu, Zheng-Tong Ding, Yu An, Jian-Jun Wu, Jian Wang
Summary: The study found that patients with Parkin-EOPD showed a slower deterioration of motor symptoms and better spatial processing ability compared to genetically undefined EOPD patients. Subtyping based on genetic features may help predict Parkinson's disease progression.
MOVEMENT DISORDERS
(2021)
Review
Neurosciences
Shenglan Hu, Jieqiong Tan, Lixia Qin, Lingling Lv, Weiqian Yan, Hainan Zhang, BeiSha Tang, Chunyu Wang
Summary: Parkinson's disease is a neurodegenerative disorder characterized by the progressive death of dopamine neurons, with mutations in PD-related genes playing a role in neuronal pathogenesis. Molecular chaperones/co-chaperones interact with PD-related proteins to modulate their function and potentially provide new therapeutic targets for the disease progression.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Clinical Neurology
Risa Isonaka, David S. Goldstein, William Zhu, Esther Yoon, Debra Ehrlich, Alice B. Schindler, Angela D. Kokkinis, Marya S. Sabir, Sonja W. Scholz, Sara Bandres-Ciga, Cornelis Blauwendraat, Pedro Gonzalez-Alegre, Grisel Lopez, Ellen Sidransky, Derek P. Narendra
Summary: This study compared the intraneuronal deposition of alpha-syn in common and rare genetic forms of Parkinson's disease, finding variations in alpha-syn deposition based on genotype. Patients with certain genetic mutations showed substantial intraneuronal alpha-syn deposition, while those with biallelic PRKN mutations did not.
MOVEMENT DISORDERS
(2021)
Article
Cell Biology
Yi-Qun Yan, Ran Zheng, Yi Liu, Yang Ruan, Zhi-Hao Lin, Nai-Jia Xue, Ying Chen, Bao-Rong Zhang, Jia-Li Pu
Summary: Parkin regulates microglial NLRP3 inflammasome activation through polyubiquitination, mitigating neurodegeneration in Parkinson's disease (PD). Loss of Parkin activity in LPS-induced mice leads to excessive microglial NLRP3 inflammasome assembly, resulting in motor impairment and dopaminergic neuron loss in the substantia nigra. Accelerating Parkin-induced NLRP3 degradation can reduce the inflammatory response and alleviate PD-related neurodegeneration. Targeting Parkin-mediated microglial NLRP3 inflammasome activity may hold therapeutic potential for PD.
Review
Cell Biology
Daniel Aghaie Madsen, Sissel Ida Schmidt, Morten Blaabjerg, Morten Meyer
Summary: This review article examines the role of Parkin and alpha-synuclein in the pathophysiology of Parkinson's disease, particularly focusing on the PARK2 gene mutations causing early-onset PD and the interaction between parkin and alpha-synuclein in protein aggregation regulation. The study provides insights into the potential formation of intracellular micro-aggregates in PARK2-related PD, suggesting new avenues for research into primary signaling processes involved in PD and related neurodegenerative disorders.
Review
Biochemistry & Molecular Biology
Frederic Checler, Cristine Alves da Costa
Summary: Alzheimer's and Parkinson's diseases are two age-related pathologies characterized by common dysfunctions and protein accumulation. The protein parkin may act as a molecular bridge between these two diseases.
Article
Biochemistry & Molecular Biology
Yuji Jeong, Taejoon Kim, Suyeun Kim, Yoon-Ki Hong, Kyoung Sang Cho, Im-Soon Lee
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Pharmacology & Pharmacy
Quan Feng Liu, Youngjae Jeon, Yung-wei Sung, Jang Ho Lee, Haemin Jeong, Young-Mi Kim, Hye Sup Yun, Young-Won Chin, Songhee Jeon, Kyoung Sang Cho, Byung-Soo Koo
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2018)
Review
Biochemistry & Molecular Biology
Kyoung Sang Cho, Jang Ho Lee, Jeiwon Cho, Guang-Ho Cha, Gyun Jee Song
CURRENT MEDICINAL CHEMISTRY
(2020)
Article
Biology
Soojin Hwang, Haemin Jeong, Eun-Hee Hong, Hae Mi Joo, Kyoung Sang Cho, Seon Young Nam
Review
Biochemistry & Molecular Biology
Youngjae Jeon, Jae Ha Lee, Byoungyun Choi, So-Yoon Won, Kyoung Sang Cho
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Taejoon Kim, Bokyeong Song, Kyoung Sang Cho, Im-Soon Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Neurosciences
Taejoon Kim, Hyewon Shin, Bokyeong Song, Chihyun Won, Hideki Yoshida, Masamitsu Yamaguchi, Kyoung Sang Cho, Im-Soon Lee
Article
Cell Biology
Chunyu Yuan, Myeongcheol Shin, Youngjae Park, Byoungyun Choi, Seokhui Jang, Chaejin Lim, Hye Sup Yun, Im-Soon Lee, So-Yoon Won, Kyoung Sang Cho
Summary: The study found that linalool can increase the survival rate of AD model flies, reduce A beta-induced apoptosis and neurodegeneration, as well as decrease oxidative stress and inflammatory responses in the brain.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biochemistry & Molecular Biology
Banseok Lee, Changmin Shin, Myeongcheol Shin, Byoungyun Choi, Chunyu Yuan, Kyoung Sang Cho
Summary: The study reveals that reducing LUBEL, kenny, or Relish in Drosophila muscles decreases accumulation of polyubiquitinated protein aggregation during aging, without affecting levels of autophagy and global translation implicated in proteostasis maintenance.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Hyemin Min, Mijin Lee, Kyoung Sang Cho, Hyunjung Jade Lim, Yhong-Hee Shim
Summary: The study found that supplementation with nicotinamide (NAM) can improve oocyte quality, reduce embryonic lethality, and promote germ cell apoptosis in female reproductive aging. NAM supplementation in aged mothers also decreases ROS accumulation and improves mitochondrial function in oocytes, resulting in improved developmental growth and motility of offspring. These results suggest that NAM supplementation in aging mothers enhances offspring health by modulating mitochondrial function and improving oocyte quality.
Review
Biochemistry & Molecular Biology
Banseok Lee, Myeongcheol Shin, Youngjae Park, So-Yoon Won, Kyoung Sang Cho
Summary: Myokines regulated by exercise have beneficial effects on neurodegenerative diseases through various mechanisms such as cell survival, neurogenesis, and neuroinflammation. Studies suggest that exercise-induced myokines could be a novel strategy for treating neurodegenerative diseases. However, research on the effects of myokines on neurodegenerative diseases is still in its early stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sun-Ok Kim, Kyoung Sang Cho, Bo Yeon Kim, Kyung Ho Lee
Summary: Primary cilia are important cell structures regulated by various cellular signals, abnormal regulation of which is related to human diseases. This study identified a novel regulatory factor CUL1, which induces Dvl2 degradation through ubiquitination to promote ciliogenesis, providing a new therapeutic target for cilia-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Seokhui Jang, Byoungyun Choi, Chaejin Lim, Banseok Lee, Kyoung Sang Cho
Summary: The study reveals that dFabp in Drosophila is involved in the development of various tissues and brain functions, and serves as a mediator of neuron-glia interactions by regulating behavior.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Banseok Lee, Byoungyun Choi, Youngjae Park, Seokhui Jang, Chunyu Yuan, Chaejin Lim, Jang Ho Lee, Gyun Jee Song, Kyoung Sang Cho
Summary: The study reveals that ZnT86D, a fruit fly ortholog of ZnT7, plays a crucial role in neurodevelopment and the pathogenesis of Alzheimer's disease. Silencing of ZnT86D in neurons resulted in toxic phenotypes, abnormal neurogenesis, and neuronal cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Myeongcheol Shin, Quan Feng Liu, Byoungyun Choi, Changmin Shin, Banseok Lee, Chunyu Yuan, You Jin Song, Hye Sup Yun, Im-Soon Lee, Byung-Soo Koo, Kyoung Sang Cho
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2020)