RhoA/ROCK-2 Pathway Inhibition and Tight Junction Protein Upregulation by Catalpol Suppresses Lipopolysaccaride-Induced Disruption of Blood-Brain Barrier Permeability

Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin

(2017) Be’eri Niego et al.   PLoS One

Catalpol protects mice against Lipopolysaccharide/D-galactosamine-induced acute liver injury through inhibiting inflammatory and oxidative response

(2017) Haogang Zhang et al.   Oncotarget

TNFα alters occludin and cerebral endothelial permeability: Role of p38MAPK

(2017) Yawen Ni et al.   PLoS One

Catalpol restores LPS-elicited rat microcirculation disorder by regulation of a network of signaling involving inhibition of TLR-4 and SRC

(2016) Yun-Pei Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Catalpol stimulates VEGF production via the JAK2/STAT3 pathway to improve angiogenesis in rats’ stroke model

(2016) Wan Dong et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cystine improves survival rates in a LPS-induced sepsis mouse model

(2015) Kenji A.K. Tanaka et al.   CLINICAL NUTRITION

Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit

(2015) William A. Banks et al.   Journal of Neuroinflammation

Catalpol downregulates vascular endothelial-cadherin expression and induces vascular hyperpermeability

(2015) CAIQING ZHANG et al.   Molecular Medicine Reports

Acute systemic LPS-mediated inflammation induces lasting changes in mouse cortical neuromodulation and behavior

(2015) Z. Ming et al.   NEUROSCIENCE LETTERS

Hypoglycemic effect of catalpol on high-fat diet/streptozotocin-induced diabetic mice by increasing skeletal muscle mitochondrial biogenesis

(2014) X. Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Protective effect of catalpol on lipopolysaccharide-induced acute lung injury in mice

(2014) Kai Fu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Role of Rho kinase in lysophosphatidic acid-induced altering of blood-brain barrier permeability

(2014) YING YU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Endothelin-1 and its role in the pathogenesis of infectious diseases

(2014) Brandi D. Freeman et al.   LIFE SCIENCES

Exploring LPS-induced sepsis in rats and mice as a model to study potential protective effects of the nociceptin/orphanin FQ system

(2014) Roisin C. Thomas et al.   PEPTIDES

Rho-kinase: regulation, (dys)function, and inhibition

(2013) Ehsan Amin et al.   BIOLOGICAL CHEMISTRY

Rho kinase inhibition by fasudil suppresses lipopolysaccharide-induced apoptosis of rat pulmonary microvascular endothelial cells via JNK and p38 MAPK pathway

(2013) Huanlong Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Neuroprotective activities of catalpol against CaMKII-dependent apoptosis induced by LPS in PC12 cells

(2013) Wenna Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Catalpol suppresses advanced glycation end-products-induced inflammatory responses through inhibition of reactive oxygen species in human monocytic THP-1 cells

(2013) Hee-Jung Choi et al.   FITOTERAPIA

Catalpol improves cholinergic function and reduces inflammatory cytokines in the senescent mice induced by d-galactose

(2013) Xiuli Zhang et al.   FOOD AND CHEMICAL TOXICOLOGY

A Novel Brain Neurovascular Unit Model with Neurons, Astrocytes and Microvascular Endothelial Cells of Rat

(2013) Qiang Xue et al.   International Journal of Biological Sciences

PKC and RhoA signals cross-talk in Escherichia coli endotoxin induced alterations in brain endothelial permeability

(2012) Fang He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Immortalized human cerebral microvascular endothelial cells maintain the properties of primary cells in an in vitro model of immune migration across the blood brain barrier

(2012) Brian P. Daniels et al.   JOURNAL OF NEUROSCIENCE METHODS

HPLC–APCI–MS/MS method for the determination of catalpol in rat plasma and cerebrospinal fluid: Application to an in vivo pharmacokinetic study

(2012) Qin Wang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Fasudil, a Rho-kinase inhibitor, attenuates lipopolysaccharide-induced vascular hyperpermeability and colonic muscle relaxation in guinea pigs

(2012) Kensuke Suzuki et al.   JOURNAL OF SURGICAL RESEARCH

Catalpol inhibits LPS plus IFN-γ-induced inflammatory response in astrocytes primary cultures

(2012) Jing Bi et al.   TOXICOLOGY IN VITRO

Blood-neural barrier: its diversity and coordinated cell-to-cell communication

(2011) Yoon-Kyung Choi et al.   BMB Reports

Rho Signaling and Tight Junction Functions

(2010) Steve Terry et al.   PHYSIOLOGY

Oral supplementation of catalpol ameliorates diabetic encephalopathy in rats

(2009) Cheng-Fang Wang et al.   BRAIN RESEARCH

Catalpol inhibits apoptosis in hydrogen peroxide-induced endothelium by activating the PI3K/Akt signaling pathway and modulating expression of Bcl-2 and Bax

(2009) Lingai Hu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The blood–brain barrier and immune function and dysfunction

(2009) William A. Banks et al.   NEUROBIOLOGY OF DISEASE

Catalpol ameliorates beta amyloid–induced degeneration of cholinergic neurons by elevating brain-derived neurotrophic factors

(2009) Z. Wang et al.   NEUROSCIENCE

Cytokine regulation of tight junctions

(2008) Christopher T. Capaldo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Effects of catalpol on mitochondrial function and working memory in mice after lipopolysaccharide-induced acute systemic inflammation

(2008) Aihong Zhang et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Lipopolysaccharide Impairs Blood–Brain Barrier P-glycoprotein Function in Mice Through Prostaglandin- and Nitric Oxide-Independent Pathways

(2008) Mohamad A. Salkeni et al.   Journal of Neuroimmune Pharmacology