期刊
MOLECULES
卷 19, 期 9, 页码 13803-13823出版社
MDPI AG
DOI: 10.3390/molecules190913803
关键词
DNA origami; atomic force microscopy; single-molecule analysis; DNA radiation damage; protein binding; enzyme reactions; G quadruplexes
资金
- Marie Curie FP7 Integration Grant within the 7th European Union Framework Programme
- Deutsche Forschungsgemeinschaft (DFG)
DNA origami nanostructures allow for the arrangement of different functionalities such as proteins, specific DNA structures, nanoparticles, and various chemical modifications with unprecedented precision. The arranged functional entities can be visualized by atomic force microscopy (AFM) which enables the study of molecular processes at a single-molecular level. Examples comprise the investigation of chemical reactions, electron-induced bond breaking, enzymatic binding and cleavage events, and conformational transitions in DNA. In this paper, we provide an overview of the advances achieved in the field of single-molecule investigations by applying atomic force microscopy to functionalized DNA origami substrates.
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