Article
Plant Sciences
Yogesh Sharma, Praveen Soni, Gaurav Raturi, Rushil Mandlik, Vinay Kumar Rachappanavar, Manish Kumar, Prafull Salvi, Durgesh Kumar Tripathi, Hasthi Ram, Rupesh Deshmukh
Summary: Metalloids are elements with properties similar to both metals and non-metals, and their impact on plant growth can be both beneficial and hazardous. This article discusses the specific role and molecular mechanism involved in the uptake and transport of different metalloids in various plant tissues. The efforts to engineer metalloid transport, such as improving the uptake of beneficial metalloids and reducing the presence of hazardous ones, are also described. Understanding the molecular insights into metalloid transport and detoxification mechanisms will aid in utilizing the benefits of metalloids for crop improvement and ensuring food safety.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2023)
Article
Microbiology
Emily E. Whittle, Helen E. McNeil, Eleftheria Trampari, Mark Webber, Tim W. Overton, Jessica M. A. Blair
Summary: Efflux is important for maintaining low intracellular accumulation only in actively growing cells, while envelope permeability is the predominant factor in stationary-phase cells. This study suggests that antibiotics with intracellular targets may be less effective in complex infections with nongrowing or slow-growing bacteria, and efflux inhibitors may potentiate the activity of existing antibiotics in actively growing bacterial infections. The remodeling of the cell envelope prior to stationary phase could provide novel drug targets.
Article
Biochemistry & Molecular Biology
Elisabetta Gabano, Ilaria Zanellato, Giulia Pinton, Laura Moro, Mauro Ravera, Domenico Osella
Summary: The biological behavior of an axially unsymmetric antitumor prodrug was investigated and compared with that of analogous symmetric Pt(IV) complexes. The study found that the unsymmetric antitumor prodrug showed higher cytotoxicity and peculiar cellular accumulation compared to the symmetric complexes.
BIOINORGANIC CHEMISTRY AND APPLICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Nanaji Arisetti, Hazel L. S. Fuchs, Janetta Coetzee, Manuel Orozco, Dominik Ruppelt, Armin Bauer, Dominik Heimann, Eric Kuhnert, Satya P. Bhamidimarri, Jayesh A. Bafna, Bettina Hinkelmann, Konstantin Eckel, Stephan A. Sieber, Peter P. Mueller, Jennifer Herrmann, Rolf Mueller, Mathias Winterhalter, Claudia Steinem, Mark Broenstrup
Summary: The study presents a concise total synthesis and mechanistic investigation of a novel antibiotic, armeniaspirol A. Armeniaspirol A exhibits potent activity against Gram-positive pathogens, potentially acting as a protonophore to exert antibiotic effects. The research also reveals an efflux-mediated resistance mechanism against armeniaspirols.
Review
Environmental Sciences
Jingyu Tao, Lingli Lu
Summary: Cadmium is a highly toxic heavy metal for plants, animals, and humans. Understanding the latest advances in Cd transporters is important for understanding the mechanisms of Cd accumulation in plants.
Review
Pharmacology & Pharmacy
Julio Cesar Monteiro Junior, Arne Kruger, Giuseppe Palmisano, Carsten Wrenger
Summary: Malaria remains a public health problem, and the emergence of drug resistance has made elimination challenging. New drugs with novel mechanisms of action are urgently needed. Transport proteins, particularly those in infected red blood cells, have shown promise as potential biological targets.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Hossein Bidi, Hormoz Fallah, Yosoof Niknejad, Davood Barari Tari
Summary: Arsenic poses a threat to rice plants, but FeNPs can alleviate its negative effects by enhancing antioxidant capacity and related enzyme systems, while promoting the accumulation of iron in roots and leaves to protect plants from arsenic toxicity.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Brady L. Weber, Jasmin N. Beaver, T. Lee Gilman
Summary: This mini review summarizes the current literature on the behavioral effects of uptake 2, with a focus on stress responsivity, psychostimulant responsivity, and antidepressant responsivity. The reviewed studies highlight the need for the development of selective uptake 2-inhibiting drugs.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Review
Chemistry, Inorganic & Nuclear
Mauro Ravera, Elisabetta Gabano, Michael J. McGlinchey, Domenico Osella
Summary: Platinum(ii)-based drugs are commonly used for solid tumor treatment, but their clinical use is limited by severe side effects and resistance. To overcome these limitations, Pt(iv) derivatives acting as anticancer prodrugs have been designed, synthesized, and preclinically tested. Although not yet approved for clinical use, these prodrugs show promising pharmacological profiles.
DALTON TRANSACTIONS
(2022)
Article
Infectious Diseases
Srinivasan Vijaya Bharathi, Govindan Rajamohan
Summary: This study characterized the genotypic and phenotypic features of a biocide-tolerant multidrug-resistant E. coli O9:H30 strain. The presence of qnrS-dependent plasmid-mediated quinolone resistance and innate enzymatic modes of multidrug resistance mechanisms were highlighted.
Article
Environmental Sciences
Diana Dimunova, Petra Matouskova, Martina Navratilova, Linh Thuy Nguyen, Martin Ambroz, Ivan Vokral, Barbora Szotakova, Lenka Skalova
Summary: This study found that the environmental circulation of veterinary anthelmintics may contribute to drug resistance in parasitic nematodes, as it improves their ability to deactivate the drugs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Agronomy
Andriele Wairich, Lessandro De Conti, Thaina Lamb, Rosana Keil, Leonardo O. Neves, Gustavo Brunetto, Raul A. Sperotto, Felipe K. Ricachenevsky
Summary: Copper is essential to plants but can also be harmful, so plants have evolved mechanisms to regulate copper uptake and accumulation. However, copper levels in soils are unstable, requiring a deeper understanding of copper homeostasis. This review examines the presence of copper in soils, plant responses to copper toxicity, the role of copper transporters, and the interaction between copper and iron homeostasis, as well as discussing copper hyperaccumulator plants and future research directions.
Article
Chemistry, Multidisciplinary
Sebastien Goutal, Anthony Novell, Sarah Leterrier, Louise Breuil, Erwan Selingue, Matthieu Gerstenmayer, Solene Marie, Bruno Saubamea, Fabien Caille, Oliver Langer, Charles Truillet, Benoit Larrat, Nicolas Tournier
Summary: In this study, the impact of focused ultrasound on P-gp function was investigated using positron emission tomography imaging. The results showed that the function of P-gp is associated with the integrity of the blood-brain barrier, and the down-regulation of P-gp function induced by focused ultrasound can be detected.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Environmental Sciences
Haoyang Wang, Teng Hu, Minghan Wang, Yunshan Liang, Chengwen Shen, Huaqin Xu, Yaoyu Zhou, Zhonghua Liu
Summary: This study investigated the effect of different amounts of biochar on fluoride (F) content in tea leaves during tea plant growth. The results showed that biochar amendment significantly reduced water-soluble F content in tea leaves, especially in the 8.0% treatment. Biochar also contributed to improving tea polyphenols and caffeine. However, it had no significant impact on free amino acids and water leachate. The application of biochar also increased soil water-soluble F content and decreased exchangeable aluminum content, which can help reduce F enrichment of tea leaves.
Review
Biology
Lara Console, Mariafrancesca Scalise
Summary: Extracellular vesicles, including exosomes, play a crucial role in promoting chemoresistance in cancer cells through various mechanisms.
Editorial Material
Chemistry, Inorganic & Nuclear
Edith C. Glazer, Angela Casini
Summary: The field of Metals in Medicine combines the disciplines of inorganic chemistry with biochemistry and physiology to study the effects of metals on human health and develop inorganic systems and materials for disease detection, monitoring, and treatment.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yasemin Aylin Sahin, Friederike Eilsberger, Eric Einspaenner, Johannes Kunz, Sarah Spreckelmeyer, Markus Luster, Winfried Brenner, Benjamin Klaesner, Adrien Holzgreve
Summary: The aim of this study was to assess the opinion of nuclear medicine professionals in Germany on establishing a young talent section within the German Society of Nuclear Medicine (DGN). An initiative group of young DGN members developed a survey questionnaire and received strong support from the participants for the establishment of a young talent section, with a particular consensus on expanding education and training activities.
NUKLEARMEDIZIN-NUCLEAR MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Guillermo Moreno-Alcantar, Pierre Picchetti, Angela Casini
Summary: The discovery of medicinal properties of gold complexes has led to the development of new anticancer drugs, which are unique in their modes of action. Current research focuses on designing drug leads with enhanced pharmacological activities and improving physicochemical properties of gold compounds. Encapsulation of gold compounds in nanocarriers or their grafting onto targeted delivery vectors may lead to new nanomedicines for clinical applications. This article provides an overview of gold anticancer compounds and a detailed review of nanoparticle-based delivery systems for gold chemotherapeutics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Medicinal
Jing-Jing Zhang, Qi-Jie Xu, Claudia Schmidt, Mohamed A. Abu el Maaty, Jinglin Song, Chunqiu Yu, Jun Zhou, Kang Han, Hao Sun, Angela Casini, Ingo Ott, Stefan Woelfl
Summary: Targeting lipid, carbohydrate, and nucleotide metabolism pathways has recently been proven as a promising option for the treatment of triple-negative breast cancer (TNBC). In this study, a multimodal anticancer platinum(II) complex, Pt(II)caffeine, was developed, which simultaneously damages mitochondria, inhibits metabolic pathways, and promotes autophagy, resulting in strong suppression of TNBC cell proliferation both in vitro and in vivo. These findings highlight the potential of Pt(II)caffeine as a metallodrug to overcome the metabolic heterogeneity of TNBC.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Nilima Manoj Kumar, Patrick Gruhs, Angela Casini, Frank Biedermann, Guillermo Moreno-Alcantar, Pierre Picchetti
Summary: In this article, a cucurbit[7]uril-based chemosensor with electrochemical signal readout for the detection of pancuronium bromide is presented. The design avoids the need for immobilization on electrode surfaces and can be used with commercially available screen-printed electrodes.
Article
Chemistry, Medicinal
Aylin Cankaya, Matthias Balzer, Holger Amthauer, Winfried Brenner, Sarah Spreckelmeyer
Summary: The purpose of this study is to optimize the precursor load of three radiopharmaceuticals. The results show that the precursor load for all three radiopharmaceuticals was successfully reduced while maintaining their quality.
EJNMMI RADIOPHARMACY AND CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Salma Mansi, Sarah V. Dummert, Geoffrey J. Topping, Mian Zahid Hussain, Carolin Rickert, Kilian M. A. Mueller, Tim Kratky, Martin Elsner, Angela Casini, Franz Schilling, Roland A. Fischer, Oliver Lieleg, Petra Mela
Summary: The study proposes a method to fabricate scaffolds using melt electrowriting, combining metal-organic frameworks and polycaprolactone to create highly ordered constructs with antibacterial properties and MRI visibility.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Gohar Ali Siddiqui, Julia A. Stebani, Darren Wragg, Phaedon-Stelios Koutsourelakis, Angela Casini, Alessio Gagliardi
Summary: In the context of drug discovery, computational methods have been utilized to accelerate the design and optimization of new drug candidates. This study applied machine learning algorithms to automatically identify the collective variables that describe the binding free energy and solvation effects of a drug and DNA complex.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Inorganic & Nuclear
Guilhem Claude, Denis Puccio, Maximilian Roca Jungfer, Adelheid Hagenbach, Sarah Spreckelmeyer, Ulrich Abram
Summary: The attachment of an ethyne substituent in the para position of phenylisocyanide enables the isocyanide to replace carbonyl ligands in the coordination sphere of technetium(I) starting materials. This ligand exchange reaction can be thermally induced and leads to the formation of a hexakis(isocyanide)technetium(I) complex. The complex can further participate in a copper-catalyzed cycloaddition reaction, resulting in the synthesis of triazole-substituted isocyanide ligands.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Sandra Deiser, Marike Drexler, Guillermo Moreno-Alcantar, Maximilian Irl, Claudia Schmidt, Thomas Guenther, Angela Casini
Summary: In this study, a self-assembled [Pd2L2]4+ metallacycle was synthesized and functionalized with the radionuclide lutetium-177 for targeted cancer therapy. The resulting compound showed good stability and in vitro properties. Additionally, a new type of metal assembly was explored, providing new insights into the field of nuclear medicine for small molecule coordination polymers.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Valeria Scalcon, Riccardo Bonsignore, Jana Aupic, Sophie R. Thomas, Alessandra Folda, Alexandra A. Heidecker, Alexander Pothig, Alessandra Magistrato, Angela Casini, Maria Pia Rigobello
Summary: Two new hybrid metallodrugs of Au(III)(AuTAML)and Cu(II) (CuTAML) were designed to synergize the anticancer activity of both the metal centerand the organic ligand. These drugs showed antiproliferative effects against breast cancer cells and retained binding activity to estrogen receptor (ERα). Furthermore, they exhibited different reactivities and cytotoxic potencies, but displayed a capacity to induce mitochondrial damage.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Suelen Ferreira Sucena, Tuerkan Ilgin Demirer, Anna Baitullina, Adelheid Hagenbach, Jacqueline Grewe, Sarah Spreckelmeyer, Juliane Maerz, Astrid Barkleit, Pedro Ivo da Silva Maia, Hung Huy Nguyen, Ulrich Abram
Summary: The controlled, self-assembled synthesis of multinuclear coordination compounds can be performed by using different approaches. The ligand systems' steric, geometric, and/or electronic factors can determine the way metal ions assemble to form large aggregates. In this study, the Pearson's acidities and preferred coordination geometries of the metal ions were used as organization principles. The ligand under study has 'soft' sulfur and 'hard' nitrogen and oxygen donors. One-pot reactions of this compound with [AuCl(tht)] and M3+ salts result in the formation of gold-based coronands that host central M3+ ions. The size of the coronand rings depends on the ionic radii of the central ions.
Review
Chemistry, Analytical
Mihyun Park, Angela Casini, Nicole Strittmatter
Summary: Mass Spectrometry Imaging (MSI) is a powerful tool for visualizing and analyzing multiple molecules in complex biological samples. Despite some molecules being difficult to access through MSI, sophisticated (bio)chemical sample treatments have been developed to overcome this. This review discusses advancements made in On-Tissue Chemical Derivatisation (OTCD), On-Tissue Enzymatic Digestion (OTED), and On-Tissue Mass Tag Labelling (OTMT) strategies, highlighting their strengths and weaknesses.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Mihyun Park, Claudia Schmidt, Sebastian Tuerck, Franziska Hanusch, Simone V. Hirmer, Ingo Ott, Angela Casini, Shigeyoshi Inoue
Summary: A dinuclear gold(I) complex with a strongly donating bis-N-heterocyclic imine ligand was synthesized and characterized. It showed highly selective anticancer effects against non-small cell lung cancer cells, particularly A549 cells. The anticancer effects were not correlated with the amount of gold uptake by the cells but correlated with its selective inhibition of cancer cells overexpressing a specific enzyme.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yasemin Aylin Sahin, Friederike Eilsberger, Eric Einspaenner, Johannes Kunz, Sarah Spreckelmeyer, Markus Luster, Winfried Brenner, Benjamin Klaesner, Adrien Holzgreve
Summary: Nuclear medicine professionals in Germany showed strong support for the establishment of a young talent section within the German Society of Nuclear Medicine. They expressed a desire to expand the range of education and training activities.
NUKLEARMEDIZIN-NUCLEAR MEDICINE
(2023)