Chemo-Enzymatic Synthesis of Silybin and 2,3-Dehydrosilybin Dimers

Antioxidant, metal-binding and DNA-damaging properties of flavonolignans: A joint experimental and computational highlight based on 7-O-galloylsilybin

(2013) Jan Vacek et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Effect of 3-O-Galloyl Substitution on the Electrochemical Oxidation of Quercetin and Silybin Galloyl Esters at Glassy Carbon Electrode

(2013) Martina Zatloukalová et al.   ELECTROANALYSIS

Biosafety and antioxidant effects of a beverage containing silymarin and arginine. A pilot, human intervention cross-over trial

(2013) Kateřina Valentová et al.   FOOD AND CHEMICAL TOXICOLOGY

Synthesis and Antimalarial Efficacy of Two-Carbon-Linked, Artemisinin-Derived Trioxane Dimers in Combination with Known Antimalarial Drugs

(2013) Bryan T. Mott et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regio- and Stereocontrolled Synthesis of Oligostilbenoids: Theoretical Highlights at the Supramolecular Level

(2013) Saraswati S. Velu et al.   JOURNAL OF NATURAL PRODUCTS

Rapid dimerization of quercetin through an oxidative mechanism in the presence of serum albumin decreases its ability to induce cytotoxicity in MDA-MB-231 cells

(2012) Anh Pham et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bioconversion of silybin to phase I and II microbial metabolites with retained antioxidant activity

(2012) Ehab A. Abourashed et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New Flavan-3-ol Dimer from Green Tea Produced from Camellia taliensis in the Ai-Lao Mountains of Southwest China

(2012) Li-Fang Zhu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Highlights on Anthocyanin Pigmentation and Copigmentation: A Matter of Flavonoid π-Stacking Complexation To Be Described by DFT-D

(2012) Florent Di Meo et al.   Journal of Chemical Theory and Computation

Tacrine-Silibinin Codrug Shows Neuro- and Hepatoprotective Effects in Vitro and Pro-Cognitive and Hepatoprotective Effects in Vivo

(2012) Xinyu Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Influence of a Flavan-3-ol Substituent on the Affinity of Anthocyanins (Pigments) toward Vinylcatechin Dimers and Proanthocyanidins (Copigments)

(2012) Frederico Nave et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Base-catalyzed oxidation of silybin and isosilybin into 2,3-dehydro derivatives

(2012) Radek Gažák et al.   TETRAHEDRON LETTERS

Multiple pathways of the reaction of 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) with (+)-catechin: Evidence for the formation of a covalent adduct between DPPH and the oxidized form of the polyphenol

(2011) A.M. Osman   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Electrochemical investigation of flavonolignans and study of their interactions with DNA in the presence of Cu(II)

(2011) Martina Zatloukalová et al.   BIOELECTROCHEMISTRY

Synthesis and Antiangiogenic Activity of New Silybin Galloyl Esters

(2011) Radek Gažák et al.   JOURNAL OF MEDICINAL CHEMISTRY

Symmetric and Asymmetric Bolaamphiphiles from Ascorbic Acid

(2011) Christian Dolle et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Biocatalytic synthesis and antitumor activities of novel silybin acylated derivatives with dicarboxylic acids

(2011) Eleni Theodosiou et al.   New Biotechnology

Enzymatic Kinetic Resolution of Silybin Diastereoisomers⊥

(2010) Daniela Monti et al.   JOURNAL OF NATURAL PRODUCTS

Exploiting enzymatic regioselectivity: a facile methodology for the synthesis of polyhydroxylated hybrid compounds

(2010) Pietro Magrone et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Large-scale separation of silybin diastereoisomers using lipases

(2010) Radek Gažák et al.   PROCESS BIOCHEMISTRY

Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquid media and evaluation of their antitumor proliferative activity

(2009) Eleni Theodosiou et al.   BIOCATALYSIS AND BIOTRANSFORMATION

Preparation of C-23 esterified silybin derivatives and evaluation of their lipid peroxidation inhibitory and DNA protective properties

(2009) Feng Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antioxidant and antiviral activities of silybin fatty acid conjugates

(2009) Radek Gažák et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chemoenzymatic preparative separation of silybins A and B

(2009) Vladimír Křen et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Significantly greater antioxidant anticancer activities of 2,3-dehydrosilybin than silybin

(2008) Axel Huber et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

2,3-Dehydrosilybin Is a Better DNA Topoisomerase I Inhibitor than Its Parental Silybin

(2008) Piyanut Thongphasuk et al.   CHEMOTHERAPY

Molecular mechanisms of silybin and 2,3-dehydrosilybin antiradical activity—role of individual hydroxyl groups

(2008) Radek Gažák et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanism of the Antioxidant Action of Silybin and 2,3-Dehydrosilybin Flavonolignans: A Joint Experimental and Theoretical Study

(2008) Patrick Trouillas et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Laccase-mediated dimerization of the flavonolignan silybin

(2007) Radek Gažák et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC