Article
Chemistry, Medicinal
Nguyen Duy Phan, Ashraf M. Omar, Sijia Sun, Juthamart Maneenet, Dya Fita Dibwe, Mao Sato, Surya Kant Kalauni, Naoki Toyooka, Tsutomu Fujii, Suresh Awale
Summary: An ethanolic extract of Abies spectabilis stem demonstrated strong cytotoxicity against MIA PaCa-2 pancreatic cancer cells, particularly under nutrient-deprived conditions. Further investigation led to the isolation of ten compounds, including a new abietane-type diterpene. The most potent compound, dehydroabietinol, not only exhibited strong anti-cancer activity but also showed potential as an anti-metastatic agent.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Plant Sciences
Pornsuda Chawengrum, Jutatip Boonsombat, Chulabhorn Mahidol, Chatchakorn Eurtivong, Prasat Kittakoop, Sanit Thongnest, Somsak Ruchirawat
Summary: Investigation of bioactive compounds from Kaempferia elegans rhizomes led to the discovery of ten new diterpenoids, including five 12,13-seco-diterpenoids. The compound abieta-8,11,13-trien-11-ol was identified as the most potent aromatase inhibitor.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Chunyu Jiang, Mengyue Yang, Chunxue Zhao, Fangshen Liu, Hangao Yang, Zhanlin Li, Tong Han, Bin Lin, Dahong Li, Huiming Hua
Summary: Twenty one abietane diterpenes were isolated from Cephalotaxus oliveri Mast, including 7 undescribed diterpenoids named cephaloliverins A-G. Metaglyptin A exhibited the strongest cytotoxicity against three human tumor cell lines (MCF-7, HepG2, and A549) and further investigations were conducted on its effects on colony formation and apoptosis in HepG2 cells.
Article
Chemistry, Applied
Nayintai Dai, Qinghu Wang, Meirong Bai, Liguo Yang, Yu Zhao
Summary: Five abietane diterpenes compounds were isolated from Caryopteris Mongholica, with one newly identified and the others being isolated from this plant for the first time. All compounds showed high cytotoxicity against A549 lung cancer cells.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Fan Xia, Li-Sha Lin, Yan-Song Ye, Lian Yang, Jin-Hua Zhao, Gang Xu
Summary: Eleven new abietane-type diterpene lactones were isolated from Salvia prattii, including five 11,12-seco-11-nor-abietane diterpenes, four 11,12-seco-abietane diterpenes, and two 20(10 -> 5)-abeo-4,5;11,12-bis-seco-abietane diterpenes. The structures of these compounds were established through various analytical techniques, and bioactivity studies showed that some of these compounds have potent antiplatelet activity.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Antonio E. M. Crotti, Mariana C. Pagotti, Ana C. B. B. Candido, Maria G. Marcal, Tatiana M. Vieira, Milton Groppo, Marcio L. A. Silva, Daniele S. Ferreira, Viviane R. Esperandim, Lizandra G. Magalhaes
Summary: Despite current treatments, Chagas Disease remains a serious public health concern. In this study, essential oils from three plant species showed promising trypanocidal potential in vitro, with TR-EO also demonstrating potential effects in vivo.
CHEMISTRY & BIODIVERSITY
(2021)
Review
Integrative & Complementary Medicine
Flavien Shimira
Summary: This review introduces the ethnobotanical uses, in vitro studies, and phytochemical analysis of the native African herbaceous plant Tetradenia riparia, and discusses its potential and commercial use in modern phytomedicine. The plant has shown antimicrobial, microbicidal, and anti-inflammatory activities, making it a potential treatment for inflammatory and infectious diseases.
JOURNAL OF HERBAL MEDICINE
(2022)
Article
Chemistry, Medicinal
Ileana Reyes-Hernandez, Paola E. Bravo-Perez, Fernando Novillo, Maria Teresa Ramirez-Apan, Maria Isabel Chavez, Ruben A. Toscano, Jose Luis Rodriguez-Chavez, Fabiola A. Lopez-Huerta, Carlos A. Mendez-Cuesta, Esteban M. Martinez, Clara H. Ramos, Guillermo Delgado
Summary: Three new ent-rosane diterpenes were isolated and characterized from the bioactive extract of Croton niveus Jacq., along with known compounds lupeol, cajucarinolide, and phytosterols. Two of the ent-rosane diterpenes exhibited activity against HCT-15 and PC-3 cancer cell lines, and docking calculations supported their proposed mode of action against PC-3 cells by interacting with NF-κB and STAT3 receptors.
Article
Plant Sciences
Reham Hammadi, Norbert Kusz, Csilla Zsuzsanna David, Zoltan Behany, Laszlo Papp, Lajos Kemeny, Judit Hohmann, Lorant Lakatos, Andrea Vasas
Summary: Research on other Euphorbia species has identified structurally similar diterpenoids with stronger cytotoxic activity in vitro, potentially serving as alternatives to ingenol mebutate.
Article
Chemistry, Medicinal
Mohamad Ali Hijazi, Khadija Hijazi, Kamal Bouhadir, Zaynab Fatfat, Maha Aboul-Ela, Hala Gall-Muhtasib, Abdalla El-Lakany
Summary: This study evaluated the potential of abietane diterpenes from the roots of Salvia libanoticum as anticancer agents, with 7a-acetylhorminone identified as the most effective compound. The results indicated the importance of oxygenated C7 for cytotoxic activity, with the carbonyl group at position C7 leading to higher activity than the hydroxyl group.
PHARMACOGNOSY MAGAZINE
(2021)
Article
Biochemistry & Molecular Biology
Abolfazl Shakeri, Toktam Hafezian, Norbert Kusz, Judit Hohmann, Motahare Boozari, Javad Mottaghipisheh, Seyed Ahmad Emami, Zahra Tayarani-Najaran, Javad Asili
Summary: The methanolic crude extract of Stachys parviflora and its sub-fractions were evaluated for their cytotoxic activities, with 1-hydroxy-tanshinone IIA showing the highest cytotoxicity. Further investigation revealed enhanced DNA fragmentation and altered protein levels in response to the methanolic extract and 1-hydroxy-tanshinone IIA.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Chemistry, Applied
Akshay Singhal, Deepika Malwal, Shankar Thiyagarajan, Indranil Lahiri
Summary: The development of antibacterial and antibiofilm composites using graphene nanoplatelets offers an effective solution to prevent biofilm formation and reduce the risk of biofilm-associated infections. This innovative strategy combines the hydrophobicity of graphene, tannic acid, silver, and epoxy to enhance the antibiofilm efficiency of coatings on surfaces, demonstrating promising potential in combating biofilm-related issues.
PROGRESS IN ORGANIC COATINGS
(2021)
Article
Parasitology
Wilsandrei Cella, Isabelle Luiz Rahal, Gabriela Catuzo Canonico Silva, Ezilda Jacomassi, Ranulfo Piau Junior, Jose Eduardo Goncalves, Daniela Dib Goncalves, Zilda Cristiani Gazim
Summary: The purpose of this study was to evaluate the larvicidal effect of essential oils extracted from Tetradenia riparia on Rhipicephalus (Boophilus) microplus larvae. The results showed that these essential oils had high larvicidal activity, indicating the presence of bioactive molecules with significant larvicidal activity in these plants.
REVISTA BRASILEIRA DE PARASITOLOGIA VETERINARIA
(2023)
Article
Chemistry, Physical
Amy Oo, Panupong Mahalapbutr, Kuakarun Krusong, Ponsiri Liangsakul, Sariyarach Thanasansurapong, Vichai Reutrakul, Chutima Kuhakarn, Phornphimon Maitarad, Atit Silsirivanit, Peter Wolschann, Siyaporn Putthisen, Khanittha Kerdpol, Thanyada Rungrotmongkol
Summary: Encapsulation with beta-cyclodextrin (β-CD) has been explored to enhance the solubility of emodin (ED) for pharmaceutical applications. In this study, inclusion complexation of ED with β-CD and its derivatives was performed to identify the most promising drug carrier. The ED/DM-β-CD complex showed the highest stability and water solubility, followed by ED/SBE7-β-CD and ED/HP-β-CD complexes. The SEM micrographs and DSC thermograms confirmed the inclusion complex formation, and molecular docking suggested C-form insertion as the preferred binding mode. Moreover, the inclusion complexes, especially ED/DM-β-CD, showed significantly higher anti-proliferative effects on cancer cell lines compared to ED alone.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Medicinal
Stefano Zoroddu, Paola Corona, Luca Sanna, Federica Borghi, Valentina Bordoni, Battistina Asproni, Gerard A. Pinna, Luigi Bagella, Gabriele Murineddu
Summary: A library of novel 1,3,4-oxadiazole bioisosteres was synthesized and evaluated for their cytotoxic activity. Several of the new compounds showed potent anticancer activity, surpassing the previously synthesized oxadiazole compound. The nature of the selenadiazole and thiadiazole rings may play a crucial role in the antitumor activity. These compounds exhibited strong cytotoxic effects in tumor cells compared to human primary cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Valerija Madzgalj, Aleksandar Petrovic, Uros Cakar, Vesna Maras, Ivana Sofrenic, Vele Tesevic
Summary: This study aimed to demonstrate the aromatic profile of wines produced from two native grape cultivars Krstac (K) and Zizak (Z). The use of enzymatic preparations and different skin contact times resulted in increased content of aromatic compounds, particularly 2-phenylethyl and isoamyl alcohols. The wines from both varieties showed higher content of certain acids and esters, which contribute to the fruity aroma and pleasant taste of the wine. Sensory evaluation showed high grades for wines with longer skin contact time.
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Tamires Barlati Vieira da Silva, Maria Ines Dias, Carla Pereira, Filipa Mandim, Marija Ivanov, Marina Sokovic, Isabel C. F. R. Ferreira, Lillian Barros, Flavio Augusto Vicente Seixas, Adelar Bracht, Rosane Marina Peralta
Summary: Kenyan purple tea is a variety of green tea plant exclusive to Kenya, known for its purple color and high content of anthocyanin polyphenols. This study aimed to identify and quantify the major anthocyanin polyphenols in the purple tea leaves and test its ability to inhibit triglyceride absorption. The results showed that the purple tea extract had strong inhibitory effects on pancreatic lipase and triglyceride digestion, suggesting that regular consumption of Kenyan purple tea may be beneficial for obesity control.
Article
Biochemistry & Molecular Biology
Alexis Pereira, Mikel Anibarro-Ortega, Marina Kostic, Antonio Nogueira, Marina Sokovic, Jose Pinela, Lillian Barros
Summary: This study aimed to upcycle quince peel into bioactive extracts (BEs) and fiber concentrates (FCs) by optimizing the multicomponent extraction processes using response surface methodology (RSM). The BEs were analyzed for phenolic compounds, organic acids, and other constituents, while FCs were characterized for their color and dietary fiber content. The validated extraction conditions resulted in high yields of bioactive constituents and FCs, demonstrating in vitro antioxidant and antimicrobial effects.
Article
Integrative & Complementary Medicine
Juliana Scanavacca, Wanessa de Campos Bortolucci, Ezilda Jacomassi, Irineia Paulina Baretta, Maria Graciela Iecher Faria, Carla Maria Mariano Fernandez, Vele Tesevic, Jasmina Glamoclija, Marina Sokovic, Nelson Barros Colauto, Giani Andrea Linde, Zilda Cristiani Gazim
Summary: This study evaluated the chemical composition and antimicrobial activity of Tetradenia riparia leaf essential oil. The essential oil showed broad antibacterial and antifungal activity, making it a potential alternative for microbial control.
BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS
(2023)
Article
Integrative & Complementary Medicine
Rosangela Rumi Sugauara, Wanessa de Campos Bortolucci, Carla Maria Mariano Fernandez, Marcia Regina Pereira Cabral, Regina Aparecida Correia Goncalves, Maria Helena Sarragiotto, Jose Eduardo Goncalves, Nelson Barros Colauto, Giani Andrea Linde, Maria Graciela Iecher Faria Nunes, Suelen Pereira Ruiz, Zilda Cristiani Gazim
Summary: This study used UHPLC-ESI/qTOF and different in vitro antioxidant methods to identify the antioxidant compounds in C. xanthocarpa leaves. The results showed that the leaves of this plant contain a high concentration of antioxidant compounds, which have potential applications in the food, cosmetic, and pharmaceutical fields.
BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS
(2023)
Review
Food Science & Technology
Jose Rivaldo dos Santos Filho, Everton da Silva Santos, Giani Andrea Linde, Nelson Barros Colauto, Regina Aparecida Correia Goncalves, Arildo Jose Braz de Oliveira
Summary: Lentinus crinitus is a fungus native to Brazil with a widespread distribution. Its fruiting bodies contain compounds with medicinal, nutritional, and biotechnological applications. It has shown various pharmacological activities such as antioxidant, antifungal, antibacterial, antiviral, and anticancer. This review provides a comprehensive analysis of its botanical description, geographical distribution, phytochemistry, pharmacological properties, nutritional value, and biotechnology potential, highlighting its potential for pharmaceutical, nutraceutical, biotechnological, and ecological applications.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biotechnology & Applied Microbiology
Janyeli Dorini Silva de Freitas, Miria Benetati Delgado Berteli, Jean Colombari Neto, Emerson Silveira Gasparotto, Affonso Celso Goncalves, Juliana Silveira do Valle, Deborah Murowaniecki Otero, Giani Andrea Linde, Camila Duarte Ferreira Ribeiro, Josiane Caetano, Douglas Cardoso Dragunski, Nelson Barros Colauto
Summary: This study assessed the biosorption of methylene blue using the spent substrate from Lentinus crinitus mushroom cultivation. The spent substrate showed a high adsorption capacity, with 99% methylene blue adsorbed at pH 3 to 9. Adsorption reached equilibrium at 40 minutes and followed the pseudo-second-order model. Each 100 g of spent substrate could adsorb 12 g of dye.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2023)
Article
Food Science & Technology
Beatriz Nunes Silva, Vasco Cadavez, Cristina Caleja, Eliana Pereira, Ricardo C. Calhelha, Mikel Anibarro-Ortega, Tiane Finimundy, Marina Kostic, Marina Sokovic, Jose Antonio Teixeira, Lillian Barros, Ursula Gonzales-Barron
Summary: This study aimed to characterize the polyphenolic profile and bioactive properties of lemon balm, sage, and spearmint extracts. The results showed that some of these extracts may have the ability to prevent food spoilage and promote health benefits while not displaying toxicity against healthy cells. Although sage extracts did not exhibit anti-inflammatory capacity, they often showed the best outcomes in terms of other bioactivities. Overall, the research provides insight into the potential of plant extracts as a source of active phytochemicals and as natural food additives.
Review
Infectious Diseases
Dejan Stojkovic, Jovana Petrovic, Tamara Carevic, Marina Sokovic, Konstantinos Liaras
Summary: This narrative review provides an overview of the potential of novel synthetic and semisynthetic compounds as antibacterials that target virulence traits in antibiotic-resistant strains. The review focuses on recent research and discusses a range of compounds that show promise in combating antibiotic resistance by targeting bacterial virulence factors. The findings suggest that further research is needed to identify and optimize new compounds with the potential to combat antibiotic-resistant bacterial infections.
Article
Food Science & Technology
Kaico Damacena de Souza, Larissa Queiroz de Magalhaes Marinho, Agnes Sophia Braga Alves, Vanessa de Lima Silva, Giani Andrea Linde Colauto, Nelson Barros Colauto, Deborah Murowaniecki Otero, Mariana Melo Costa, Carolina Oliveira de Souza, Camila Duarte Ferreira Ribeiro
Summary: The search for new practices to meet consumer demand in the food market is important for new product development in gastronomy. This study analyzed the insertion of gastronomy in the development of new food products in the technological context by reviewing 921 patent documents. The results showed increasing patenting trends in new food product development, offering insights into potential trends in industrial and technological research in the food sector.
INTERNATIONAL JOURNAL OF GASTRONOMY AND FOOD SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Douglas Dourado, Fabiana Pacheco Reis Batista, Biane Oliveira Philadelpho, Myla Lobo de Souza, Mariana Barros de Cerqueira e Silva, Rone Aparecido de Grandis, Priscila Anjos Miranda, Nelson Barros Colauto, Daniel T. T. Pereira, Fabio Rocha Formiga, Eduardo Maffud Cilli, Fernando Rogerio Pavan, Carolina Oliveira de Souza, Ederlan de Souza Ferreira
Summary: This study evaluated the effects of Attalea funifera seed oil with or without resveratrol entrapped in organogel nanoparticles on A375 human melanoma tumor cells in vitro. The organogel nanoparticles formed functional particles with desirable characteristics and showed cytotoxic activity against tumor cells. The entrapped resveratrol showed reduced cytotoxicity against non-tumor cells, making it a potential new platform for melanoma treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Horticulture
Angela Fernandes, Nikolaos Polyzos, Filipa Mandim, Carla Pereira, Jovana Petrovic, Marina Sokovic, Spyridon A. Petropoulos
Summary: The aim of this study was to evaluate the effects of different biostimulant formulations with various application regimes, combined with or without mineral fertilizers, on the yield parameters and fruit quality of watermelon plants. The results showed that the W5 treatment resulted in the highest yield due to increased fruit formation. Different treatments had varying effects on the content of fat, proteins, carbohydrates, sugars, and acids in the watermelon fruit.
Article
Chemistry, Multidisciplinary
Rodrigo M. V. Silva, Ana Laura M. Brand, Natalia A. B. Tinoco, Suely P. Freitas, Claudia M. Rezende
Summary: Cold pressing is an environmentally friendly method to extract oil from seeds. The study investigated the influence of pressing variables on the chemical composition of cold-pressed green Arabica coffee oil, specifically on the content of diterpenes and serotonin amides. The yield of oil from screw pressing varied depending on particle size and temperature. The fatty acid content showed no significant difference among different pressing conditions. The diterpenes kahweol and cafestol, as well as the Cn-5HTs, were present in varying amounts in the coffee oil. The biological activity and relevance of these compounds are discussed.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2023)
