期刊
MOLECULES
卷 19, 期 9, 页码 13305-13318出版社
MDPI
DOI: 10.3390/molecules190913305
关键词
pullulan; glycyrrhetic acid; self-aggregated nanoparticle; curcumin; drug delivery
资金
- National Natural Science Foundation of China [30973922]
- Teamwork Projects - Guangdong Natural Science Foundation [9351503102000001]
- Central Government Special Funds Supporting the Development of Local Colleges and Universities
- Administration of Traditional Chinese Medicine of Guangdong Province, China [2010408]
Glycyrrhetic acid (GA)-modified pullulan nanoparticles (GAP NPs) were synthesized as a novel carrier of curcumin (CUR) with a degree of substitution (DS) of GA moieties within the range of 1.2-6.2 groups per hundred glucose units. In the present study, we investigated the physicochemical characteristics, release behavior, in vitro cytotoxicity and cellular uptake of the particles. Self-assembled GAP NPs with spherical shapes could readily improve the water solubility and stability of CUR. The CUR release was sustained and pH-dependent. The cellular uptake of CUR-GAP NPs was confirmed by green fluorescence in the cells. An MTT study showed CUR-GAP NPs with higher cytotoxicity in HepG2 cells than free CUR, but GAP NPs had no significant cytotoxicity. GAP is thus an excellent carrier for the solubilization, stabilization, and controlled delivery of CUR.
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