期刊
MOLECULES
卷 19, 期 6, 页码 7072-7093出版社
MDPI
DOI: 10.3390/molecules19067072
关键词
L-rhamnal; C-glycosylation; genistein conjugates; cell cycle
资金
- European Union [POIG.01.01.02-14-102/09]
- Polish National Science Centre [DEC-2011/01/N/NZ4/01141]
A series of glycoconjugates, derivatives of genistein containing a C-glycosylated carbohydrate moiety, were synthesized and their anticancer activity was tested in vitro in the human cell lines HCT 116 and DU 145. The target compounds 15-17 were synthesized by treating.-bromoalkyl C-glycosides derived from L-rhamnal (1) with a tetrabutylammonium salt of genistein. The new, metabolically stable analogs of previously studied O-glycosidic genistein derivatives inhibited proliferation of cancer cell lines through inhibition of the cell cycle.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据