期刊
MOLECULES
卷 19, 期 7, 页码 10011-10032出版社
MDPI AG
DOI: 10.3390/molecules190710011
关键词
plumbagin; natural products; leukemia; cancer; reactive oxygen species; glutathione; apoptosis; thiol groups
资金
- European Union [215009]
- Televie grants (Fonds National de la Recherche Scientifique, Belgium)
- Action Lions Vaincre le Cancer
- Fondation de Recherche Cancer et Sang
- Recherches Scientifiques Luxembourg association
- Een Haerz fir kriibskrank Kanner association
- Action Lions Vaincre le Cancer association
- Televie Luxembourg
- National Research Foundation (NRF) by the MEST of Korea [2012-0001184]
Plumbagin is a plant naphtoquinone exerting anti-cancer properties including apoptotic cell death induction and generation of reactive oxygen species (ROS). The aim of this study was to elucidate parameters explaining the differential leukemia cell sensitivity towards this compound. Among several leukemia cell lines, U937 monocytic leukemia cells appeared more sensitive to plumbagin treatment in terms of cytotoxicity and level of apoptotic cell death compared to more resistant Raji Burkitt lymphoma cells. Moreover, U937 cells exhibited a ten-fold higher ROS production compared to Raji. Neither differential incorporation, nor efflux of plumbagin was detected. Pre-treatment with thiol-containing antioxidants prevented ROS production and subsequent induction of cell death by apoptosis whereas non-thiol-containing antioxidants remained ineffective in both cellular models. We conclude that the anticancer potential of plumbagin is driven by pro-oxidant activities related to the cellular thiolstat.
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