期刊
MOLECULES
卷 18, 期 6, 页码 7145-7159出版社
MDPI
DOI: 10.3390/molecules18067145
关键词
click chemistry; azide; bioorthogonal; glycosylation; glycobiology
资金
- National Basic Research Program of China [2012CB822103, 2011CB910603]
- National Natural Science Foundation [31170771]
- Shanghai Natural Science Foundation of China [11ZR1416000]
Click chemistry is a powerful chemical reaction with excellent bioorthogonality features: biocompatible, rapid and highly specific in biological environments. For glycobiology, bioorthogonal click chemistry has created a new method for glycan non-invasive imaging in living systems, selective metabolic engineering, and offered an elite chemical handle for biological manipulation and glycomics studies. Especially the [3 + 2] dipolar cycloadditions of azides with strained alkynes and the Staudinger ligation of azides and triarylphosphines have been widely used among the extant click reactions. This review focuses on the azide-based bioorthogonal click chemistry, describing the characteristics and development of these reactions, introducing some recent applications in glycobiology research, especially in glycan metabolic engineering, including glycan non-invasive imaging, glycomics studies and viral surface manipulation for drug discovery as well as other applications like activity-based protein profiling and carbohydrate microarrays.
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