Article
Biochemistry & Molecular Biology
Hai Huang, Jun-Koo Yi, Su-Geun Lim, Sijun Park, Haibo Zhang, Eungyung Kim, Soyoung Jang, Mee-Hyun Lee, Kangdong Liu, Ki-Rim Kim, Eun-Kyong Kim, Youngkyun Lee, Sung-Hyun Kim, Zae-Young Ryoo, Myoung Ok Kim
Summary: Costunolide (CTD) shows potential anticancer abilities in oral cancer by effectively suppressing proliferation, migration, and invasion of oral cancer cells, inducing cell cycle arrest and apoptosis. CTD binds to AKT directly, represses AKT activities, induces the generation of reactive oxygen species, and suppresses cell-derived xenograft oral cancer tumor growth in vivo, promising to be a novel AKT inhibitor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Anindita Ghosh, Rituparna Roy, Essha Chatterjee, Biswabandhu Bankura, Santosh Guru, Chinmay Kumar Panda
Summary: A novel triterpenoid and two other triterpenoids, including holarol(1) and oneseco-triterpenoid(2), were isolated from Holarrhena antidysenterica(L.)Wall. These compounds demonstrated cytotoxic activities and potential as anticancer agents, with holarol(1) and oneseco-triterpenoid(2) showing high sensitivity against bladder cancer cell line T24.
NATURAL PRODUCT RESEARCH
(2021)
Article
Oncology
Jie Du, Fan Jiang, Shen-Sheng Xu, Zi-Feng Huang, Li-Li Chen, Li Li
Summary: Tephrosin exhibits potent anticancer activity against pancreatic cancer cells by suppressing cell viability and promoting apoptosis through increased ROS production and DNA damage. Additionally, it demonstrates strong antitumor activity with low toxicity in a mouse model.
Article
Medicine, Research & Experimental
Renkai Li, Chengwen Zheng, Polly Ho-Ting Shiu, Panthakarn Rangsinth, Wen Wang, Yiu-Wa Kwan, Emily Sze-Wan Wong, Yanbo Zhang, Jingjing Li, George Pak-Heng Leung
Summary: Despite various therapeutic approaches, developing novel and more effective methods for colorectal cancer treatment is crucial due to its high fatality rate. The recent study explored the anticancer effects of GAR E, a bioactive xanthone found in mangosteen, and identified the involvement of the ROS/JNK signaling pathway in its mechanism of action. The experiments demonstrated that GAR E inhibited colony formation and wound healing in cancer cells, triggered ROS production, induced mitochondrial dysfunction and apoptosis, and caused cell cycle arrest. In vivo experiments also confirmed the antitumor effect of GAR E in a xenograft mouse model. These findings suggest that GAR E could be a potential chemotherapeutic agent for colorectal cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Environmental Sciences
Yong Jun Choi, Jongsung Lee, Sang Hoon Ha, Han Ki Lee, Heui Min Lim, Seon-Hak Yu, Chang Min Lee, Myeong Jin Nam, Yung-Hun Yang, Kyungmoon Park, Youn Soo Choi, Kyu Yun Jang, See-Hyoung Park
Summary: 6,8-Diprenylorobol inhibits proliferation of LoVo and HCT15 colon cancer cells in a dose- and time-dependent manner. It activates p53 and generates ROS, leading to decreased cell viability and increased apoptotic cell portion.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Federica Rinaldi, Linda Maurizi, Jacopo Forte, Massimiliano Marazzato, Patrizia Nadia Hanieh, Antonietta Lucia Conte, Maria Grazia Ammendolia, Carlotta Marianecci, Maria Carafa, Catia Longhi
Summary: The study demonstrated that oil-in-water nanoemulsions are an effective approach to improve the bioavailability of Resveratrol and significantly decrease the viability of bladder cancer cells.
Article
Oncology
Jun Sang, Lu Gan, Ming-Feng Zou, Zi-Jun Lin, Run-Zhu Fan, Jia-Luo Huang, Wei Li, Gui-Hua Tang, Sheng Yin
Summary: This study found that the combination therapy of a natural anti-cancer agent Jolkinolide B (JB) and mTOR inhibitors (mTORi) can effectively treat bladder cancer. JB inhibits Akt signaling and cytoprotective autophagy, enhancing the anti-proliferative effects of mTORi. Furthermore, mTORi enhances the pro-apoptotic and pro-paraptotic effects of JB through activating endoplasmic reticulum stress and MAPK pathways.
Article
Pharmacology & Pharmacy
Rong Sheng Zhou, Ji Zhong Zhao, Li Ming Guo, Jia Li Guo, Aida El Makawy, Zong Yun Li, Shao Chin Lee
Summary: The study demonstrates that clinopodiside A inhibits the growth of bladder cancer cells through autophagy mediated by BLK and RasGRP2 signaling. It has a synergistic effect with cisplatin, enhancing autophagy and autophagy-promoted apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Chang Min Lee, Jongsung Lee, Mi-Ae Kang, Hee Taek Kim, Jongbok Lee, Kyungmoon Park, Yung-Hun Yang, Kyu Yun Jang, See-Hyoung Park
Summary: Linifanib has been shown to efficiently inhibit receptor tyrosine kinases, and in this study, its anti-cancer effects in ovarian cancer were investigated. Linifanib was found to inhibit proliferation and induce apoptosis in SKOV3 cells, as well as cause DNA damage and increase intracellular ROS levels.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Oncology
Emily A. Garcia, Ilsa Bhatti, Elizabeth S. Henson, Spencer B. Gibson
Summary: This study found that the lysosome-targeted drug, siramesine, induced cell death in prostate cancer cells through lipid peroxidation. In combination with the kinase inhibitor lapatinib, it increased cell death. This provides a new strategy to treat aggressive prostate cancer cells.
Review
Biochemistry & Molecular Biology
Javier Florido, Cesar Rodriguez-Santana, Laura Martinez-Ruiz, Alba Lopez-Rodriguez, Dario Acuna-Castroviejo, Iryna Rusanova, Germaine Escames
Summary: ROS are highly reactive molecules that regulate important signaling pathways. Tumor cells have altered redox balance compared to normal cells, making them susceptible to anti-tumoral therapy targeting ROS levels and antioxidant system capacity. Melatonin has potential as an innovative cancer treatment, but its mechanism of action remains unclear, limiting its clinical applications.
Article
Pharmacology & Pharmacy
Huiai Lu, Chunlei Mei, Luhao Yang, Junyan Zheng, Junwei Tong, Fengsen Duan, Huageng Liang, Ling Hong
Summary: According to the study, PPM-18 induces autophagy and apoptosis in bladder cancer cells through activating the AMPK pathway, and it also accumulates reactive oxygen species (ROS) via ROS pathways to induce autophagy and apoptosis in bladder cancer cells, showing potential anticancer effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hanbing Jiang, Siying Zhu, Bin Wu, Yinyin Su, Qiming Wang, Yonghua Lei, Qiuju Shao, Yun Gao, Ke Gao, Guojun Wu
Summary: This study investigated the molecular mechanism of liensinine (LIEN) in the management of bladder cancer (BCa). The findings suggest that LIEN may promote senescence and inhibit proliferation of BCa by inhibiting the CDK2/4 and PI3K/AKT pathways.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Cell Biology
Cuixiang Xu, Xiaoyan Huang, Xiaohua Lei, Zhankui Jin, Min Wu, Xiao Liu, Yubin Huang, Xiangrong Zhao, Yue Xiong, Jingying Sun, Xianglong Duan, Jianhua Wang
Summary: In this study, it was found that Cos significantly inhibited the growth of HGC-27 and SNU-1 cells and induced cell cycle arrest at the G2/M phase. This effect was achieved by promoting ROS levels, inhibiting the AKT/GSK3 beta pathway, and activating autophagy to induce apoptosis in gastric cancer cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Ali H. El-Far, Kavitha Godugu, Ahmed E. Noreldin, Amna A. Saddiq, Omar A. Almaghrabi, Soad K. Al Jaouni, Shaker A. Mousa
Summary: The active ingredients of Nigella sativa seeds and Costus speciosus, thymoquinone (TQ) and costunolide (COS), respectively, have been shown to induce apoptosis in senescent cancer cells more effectively than in their corresponding proliferative cells. This study highlights the potential of TQ and COS as promising therapeutic agents for targeting senescent cancer cells.
INTEGRATIVE CANCER THERAPIES
(2021)
Article
Endocrinology & Metabolism
Muhammad Furqan Akhtar, Syed Ahmad Raza, Ammara Saleem, Irfan Hamid, Mirza Muhammad Faran Ashraf Baig, Ali Sharif, Kashif Sohail, Zeeshan Javaid, Uzma Saleem, Azhar Rasul
Summary: The study evaluated the anti-arthritic and anti-inflammatory activities of Peganum harmala leaf extract. The results showed that Peganum harmala has potential antioxidant, anti-inflammatory, and antiarthritic activities.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2022)
Review
Oncology
Muhammad Adnan, Azhar Rasul, Muhammad A. Shah, Ghulam Hussain, Muhammad Asrar, Ammara Riaz, Iqra Sarfraz, Arif Hussain, Khatereh Khorsandi, Ngit S. Lai, Syed M. Hussain
Summary: The identification and development of radioprotective agents have become an important area of research. Polyphenols extracted from plants have the potential to be ideal candidates due to their low cost, safety, and selectivity. Polyphenols have shown efficacy for radioprotection through mechanisms such as detoxification of free radicals, modulation of inflammatory responses, DNA repair, stimulation of hematopoietic recovery, and immune functions. Some polyphenols also possess antioxidant and anti-inflammatory properties, providing cell protection.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Review
Biochemical Research Methods
Iqra Sarfraz, Azhar Rasul, Ghulam Hussain, Muhammad Ajmal Shah, Bushra Nageen, Farhat Jabeen, Zeliha Selamoglu, Ilknur Ucak, Muhammad Asrar, Sevki Adem
Summary: Oxalis corniculata is a medicinal herb that grows in warm temperate and tropical regions. It has various bioactive compounds that have shown protective effects and biological activities. Despite its recognized usage, there is a lack of clinical trials and comprehensive pharmacological studies. However, this plant species has the potential for treating various diseases and further research is needed to explore its pharmacological applications.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2022)
Article
Pharmacology & Pharmacy
Shazia Anwer Bukhari, Aysha Yasmin, Azhar Rasul, Muhammad Asif Zahoor, Ghulam Mustafa, Dunia A. Al Farraj, Noura M. Darwish, Lotfi Aleya, Asim Rehman
Summary: The study suggests that ascorbic acid and gallic acid have the potential to treat obesity-induced type 2 diabetes by inhibiting secreted frizzled-related protein 4.
Article
Chemistry, Applied
Muhammad Faheem Akhtar, Hira Ashraf, Muhammad Uzair, Shabbir Ahmad, Akhtar Rasul, Ghulam Abbas, Shahid Shah, Muhammad Hanif
Summary: The study focused on designing and evaluating controlled porosity osmotic pump tablets of enalapril maleate for hypertension treatment. Through D-optimal response surface design, variables like cellulose acetate and osmotic agents were considered, with physicochemical parameters of tablets as responses. The optimized CPOP formulation showed improved drug release property and stability in accelerated stability study.
JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH
(2022)
Article
Chemistry, Applied
Misbah Hameed, Akhtar Rasul, Sumera Latif, Maria Rasool, Ghulam Abbas, Muhammad Irfan Siddique, Muhammad Khurram Waqas, Ikram Ullah Khan, Abid Mehmood Yousaf, Pervaiz Akhtar Shah
Summary: This study successfully formulated a hybrid gel containing chitosan-coated moxifloxacin hydrochloride nanoparticles with enhanced antibacterial and healing properties. In vitro and in vivo experiments showed that the hybrid gel exhibited good drug release performance and stability, making it effective for treating acute and challenged topical wounds.
JOURNAL OF MICROENCAPSULATION
(2022)
Article
Biochemistry & Molecular Biology
Ali Irfan, Sadia Faiz, Azhar Rasul, Rehman Zafar, Ameer Fawad Zahoor, Katarzyna Kotwica-Mojzych, Mariusz Mojzych
Summary: Ultrasound- and microwave-assisted green synthetic strategies were used to synthesize benzofuran-oxadiazole and benzofuran-triazole derivatives. These derivatives exhibited low toxicity to red blood cells, high thrombolysis activity, and promising anticancer potential.
Article
Biochemistry & Molecular Biology
Ali Irfan, Ameer Fawad Zahoor, Azhar Rasul, Sami A. Al-Hussain, Shah Faisal, Sajjad Ahmad, Rida Noor, Muhammed Tilahun Muhammed, Magdi E. A. Zaki
Summary: In this study, BTEAC was used as a phase transfer catalyst to improve the synthesis of S-alkylated bromobenzofuran-oxadiazole scaffolds BF1-9 with a yield of up to 88%. The bromobenzofuran-oxadiazole hybrids BF1-9 were evaluated in vitro for their anti-hepatocellular cancer activity and in silico for their therapeutic potential against six key cancer targets. The bromobenzofuran structural motifs BF-2, BF-5, and BF-6 showed the highest anti-cancer potential and least cell viabilities against the HepG2 liver cancer cell line.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Muhammad Asim, Marriam Nazir, Zunera Chauhdary, Muhammad Irfan, Syed Haroon Khalid, Sajid Asghar, Raed I. Usra, Raed Felimban, Mohammed A. S. Majrashi, Mohannad S. Hazzazi, Mohammed Alissa, Safa H. Qahl, Ghulam Hussain, Azhar Rasul, Shahzad Ali Shahid Chatha, Ikram Ullah Khan
Summary: The current study aimed to enhance the solubility and dissolution profile of dexibuprofen (Dex) by formulating ternary solid dispersions (TSDs) through solvent evaporation. The TSD formulations showed improved solubility and dissolution, as well as gastric protection and anti-inflammatory activity.
Article
Biochemistry & Molecular Biology
Gul Bushra Khan, Muhammad Qasim, Azhar Rasul, Usman Ali Ashfaq, Abdullah M. Alnuqaydan
Summary: In this study, virtual screening tools were used for structure-based drug discovery and 115 inhibitors with higher selectivity and binding affinity were identified for the enzyme 6-phosphogluconate dehydrogenase. Molecular dynamics simulations revealed three potential hits with stable confirmation. In vitro assays and cytotoxicity assays demonstrated the anticancer activity of these compounds against various cancer cell lines, particularly lung cancer.
Article
Chemistry, Medicinal
Naheed Akhter, Sidra Batool, Samreen Gul Khan, Nasir Rasool, Fozia Anjum, Azhar Rasul, Sevki Adem, Sadaf Mahmood, Aziz Ur Rehman, Mehr Un Nisa, Zainib Razzaq, Jorn B. Christensen, Mohammed A. S. Abourehab, Syed Adnan Ali Shah, Syahrul Imran
Summary: In this study, triazole-based acetamides were synthesized by chemically modifying 2-(4-isobutylphenyl) propanoic acid. The target compounds were produced in good yields and their structures were confirmed by various physiochemical and spectroscopic methods. The anti-liver carcinoma effects of these compounds were investigated and compound 7f showed the highest anti-proliferative activity with low toxicity. Molecular docking revealed that compound 7f exhibited excellent binding affinities to c-kit tyrosine kinase and protein kinase B. Therefore, compound 7f is considered as a suitable drug candidate for the treatment of hepatocellular carcinoma.
Article
Chemistry, Medicinal
Aasma Munawwar, Amna Sajjad, Azhar Rasul, Mehran Sattar, Farhat Jabeen
Summary: Cancer therapies using nanoparticles loaded with a drug can overcome the toxic effects of traditional chemotherapy. In this study, LLY-507, a potent inhibitor of SMYD2, was loaded onto iron oxide nanoparticles (IONPs) and characterized for size, loading efficiency, and drug release. The results showed that LLY-507-loaded IONPs had strong anticancer potential with lower IC50 values compared to LLY-507 alone. In a mouse model of lung cancer, LLY-507 effectively suppressed tumor growth, emphysema, hemorrhage, and congestion by inhibiting the SMYD2 protein.
Article
Medicine, General & Internal
Mohsana Tariq, Farjad Afzal, Akhtar Rasul, Iqra Manan, Ayesha Munawar, Saira Aslam
Summary: The study found a positive correlation between BMI and body fat, and individuals with high body fat are at a greater risk for cardiovascular diseases, type 2 diabetes, and gynecological problems compared to those with high BMI.
RAWAL MEDICAL JOURNAL
(2022)
Article
Entomology
Rameesha Amjad Ali, Mansoor ul Hasan, Muhammad Sagheer, Shahbaz Talib Sahi, Amer Rasul
Summary: The study evaluated the combined action of diatomaceous earth and zeolite with abamectin and spinetoram against Trogoderma granarium. Complete mortality (100%) of insects was achieved at 35 degrees C and 55% R.H. after 14 days of exposure. Results indicated that higher temperature and reduced R.H. led to increased mortality rates.
INTERNATIONAL JOURNAL OF TROPICAL INSECT SCIENCE
(2022)