Review
Pharmacology & Pharmacy
Haoyuan Peng, Lei Zhong, Lin Cheng, Lu Chen, Rongsheng Tong, Jianyou Shi, Lan Bai
Summary: Ganoderma lucidum, also known as Lingzhi, is a widely-used herbal medicine with various pharmacological effects including antioxidant, antitumor, anti-aging, anti-liver fibrosis, and immunomodulation. Its main active components include triterpenoids, polysaccharides, sterols, peptides, and other bioactive ingredients. The triterpenoids and polysaccharides in G. lucidum have shown significant anti-liver fibrotic effects. Given the global increase in liver fibrosis cases, this review summarizes the role of G. lucidum extract in anti-liver fibrosis and its effects on fibrosis induced by different causes, providing insights for the development of G. lucidum extracts in anti-liver fibrosis treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Vijay Laxmi Trivedi, Ruchi Soni, Praveen Dhyani, Priyanka Sati, Silvia Tejada, Antoni Sureda, William N. Setzer, Ahmad Faizal Abdull Razis, Babagana Modu, Monica Butnariu, Javad Sharifi-Rad
Summary: With the development of highly effective plant-based medications, the use of phytomedicines against complex diseases like cancer is increasing. This review focuses on the traits, roles, and mechanisms of the pentacyclic triterpenes known as boswellic acids (BAs) and their semi-synthetic derivatives in treating certain cancers. The review also explores the sources of BAs, their conservation, and the potential of biotechnology in improving BA production.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Chemistry, Medicinal
Afshin Zare, Safoura Izanloo, Sajed Khaledi, Mussin Nadiar Maratovich, Asset Askerovich Kaliyev, Nurgul Abdullayevna Abenova, Farhad Rahmanifar, Mahdi Mahdipour, Shabnam Bakhshalizadeh, Reza Shirazi, Nader Tanideh, Amin Tamadon
Summary: Sea cucumber is a marine-derived source for discovering anti-lung cancer compounds. Triterpene glucosides were found to be the most frequently identified compounds with anti-cancer properties in sea cucumbers. Among them, Intercedenside C, Scabraside A, and Scabraside B showed the highest affinity for apoptotic receptors in lung cancer cells.
Article
Biotechnology & Applied Microbiology
Mikal El-Hajjar, Lara Gerhardt, Megan M. Y. Hong, Mithunah Krishnamoorthy, Rene Figueredo, Xiufen Zheng, James Koropatnick, Saman Maleki Vareki
Summary: Immune checkpoint blockade is effective against highly immunogenic mismatch repair-deficient tumors but not neuroblastoma. However, stimulating T cell-based therapy and memory T cell-dependent gene expression can improve survival in high-risk neuroblastoma patients. Inducing mismatch repair deficiency and combining it with anti-CTLA4 therapy can serve as a novel T cell-based treatment strategy for neuroblastoma.
Article
Biochemistry & Molecular Biology
Rong-Wei Kou, Bing Xia, Zhi-Ju Wang, Jian-Nan Li, Jun-Ren Yang, Yu-Qi Gao, Xia Yin, Jin-Ming Gao
Summary: Ganoresinoid A from Ganoderma resinaceum exhibits anti-inflammatory, antioxidative, and anti-apoptosis activities. It inhibits the release of inflammatory cytokines and reduces cell apoptosis by suppressing TLR-4/NF-κB and MAPK signaling pathways. In addition, Ganoresinoid A has antioxidant effects by activating the Akt/GSK-3β/Nrf2 signaling pathway. These findings provide a theoretical basis for using Ganoresinoid A as a nutritional intervention for neurodegenerative diseases.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Liping Cao, Hongliu Jin, Qi Liang, Haiyi Yang, Shuguang Li, Zhicheng Liu, Zhongwen Yuan
Summary: Ganoderma lucidum, a traditional medicinal fungus in China, has been found to possess a new triterpene compound that shows moderate anti-tumor activities, possibly inducing apoptosis through the p53/caspase-3 pathway.
NATURAL PRODUCT RESEARCH
(2022)
Article
Fisheries
Xue Qiao, Lilin Hou, Jihan Wang, Yuhao Jin, Ning Kong, Jialuo Li, Sicong Wang, Lingling Wang, Linsheng Song
Summary: The study identified a homologue of AIF, CgAIF1, in oysters, which shares a similarity of 35.44% to 79.22% with AIF1s from other species. Upon LPS and Poly (I:C) stimulation, the mRNA transcripts of CgAIF1 in gills significantly increased.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Plant Sciences
Jean Paul Dzoyem, Dieu Ne Dort Nganteng, Raduis Melong, Pascal Wafo, Bonaventure Ngadjui, Eric Allemann, Florence Delie
Summary: This study identified pentacyclic triterpenes, specifically pomolic and tormentic acids, as the main active compounds responsible for the anti-inflammatory effects of Ocimum gratissimum extract. These compounds showed potential in inhibiting nitric oxide production, IFN-gamma cytokine secretion, COX enzyme activity, and inducing apoptosis in activated macrophages. The findings provide evidence for the traditional use of Ocimum gratissimum in treating inflammatory disorders and suggest the multitarget potential of pomolic and tormentic acids as future drugs for inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Hongxin Yang, Siyu Li, Yidi Qu, Lanzhou Li, Yu Li, Di Wang
Summary: This study investigated the effects of Inonotus hispidus spore powder on colorectal cancer and its potential mechanisms. The results showed that Inonotus hispidus spore powder influenced the gut microbiota and serum metabolites, regulated the levels of cytokines and T cells, and suppressed tumor development.
Article
Oncology
Junjie Lu, Bo Shuai, Zhexing Shou, Weina Guo, Cong Zhou, Xiaohu Ouyang, Haifeng Zhou, Junyi Li, Jing Cui, Feng Jiang, Kim Yun Jin, Alexey Sarapultsev, Fangfei Li, Ge Zhang, Shanshan Luo, Desheng Hu
Summary: Taraxasterol (TAX) has been found to inhibit the growth and migration of lung cancer cells, induce cancer cell apoptosis, and modulate the tumor microenvironment. These findings suggest that TAX could be a potential natural drug for lung cancer therapy.
Article
Pharmacology & Pharmacy
Yingxue Xue, Yifei Yin, He Li, Mingyu Chi, Jiaxin Guo, Guihua Cui, Wenliang Li
Summary: A dimeric Keggin-type phosphotungstate showed promising anticancer activity on MCF-7 and A549 cells, inducing apoptosis and S phase arrest. The characterization of the dimeric structure and morphology, along with in vitro assays, supported its potential as an anticancer drug.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Hee-Yun Kim, Hanchul Jung, Hyung-Min Kim, Hyun-Ja Jeong
Summary: Surfactin exhibits significant anti-cancer effects on melanoma skin cancer by enhancing immune response and inducing apoptosis of melanoma cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yu-Yue Zhao, Jun-Xiang Lian, Zhou Lan, Ke-Long Zou, Wei-Ming Wang, Guang-Tao Yu
Summary: This study found that ferroptosis can reverse the immunosuppressive tumor microenvironment and promote anti-tumor immune response. High expression of GPX4 was associated with poor survival, while the expression of GPX4 was negatively correlated with calreticulin, a protein related to immunogenic cell death.
Article
Oncology
Nyamsambuu Altannavch, Xi Zhou, Md Asaduzzaman Khan, Ashfaque Ahmed, Shinen Naranmandakh, Jun-Jiang Fu, Han-Chun Chen
Summary: This study investigates the biological activity of F. officinalis and evaluates the antioxidant and anticancer activity of six fractions of its residues against hepatocellular carcinoma. The results show that all six fractions have antioxidant activity and the chloroformic extract has significant anticancer effects, promoting cancer cell apoptosis and cell cycle activation.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Ziqi Yu, Xue Dong, Mei Song, Aizhang Xu, Qing He, Huilin Li, Wen Ouyang, Lotfi Chouchane, Xiaojing Ma
Summary: This study demonstrates the important role of UBR5 in driving breast cancer metastasis by regulating the CDC73 and p53 pathways, affecting tumor cell apoptosis and proliferation. It provides a potential target for cancer therapy.
INTERNATIONAL JOURNAL OF CANCER
(2023)