Article
Plant Sciences
Dipti Tonk, Abdul Mujib, Mehpara Maqsood, Mir Khusrau, Ali Alsughayyir, Yaser Hassan Dewir
Summary: This study investigated the effect of Fusarium oxysporum on the yields of vinblastine and vincristine alkaloids in Catharanthus roseus embryos. The addition of F. oxysporum extract improved the growth of callus biomass and enhanced the accumulation of vinblastine and vincristine in the tissues. Low doses of the Fusarium treatment resulted in high germination rates and longer shoot and root lengths of somatic embryos. The yields of vinblastine and vincristine were measured, with the highest and increased yields observed in F. oxysporum-amended tissues.
Review
Plant Sciences
Anamika Paul, Krishnendu Acharya, Nilanjan Chakraborty
Summary: The demand for natural products has led to increased interest in the medicinal plant Catharanthus roseus. This plant is known for its traditional pharmacological applications and its rich phytochemical composition, particularly alkaloids. Among these alkaloids, vinblastine and vincristine are of great importance as expensive anti-cancer compounds. This review provides an overview of the biosynthesis, extraction, detection, mode of action, and limitations of vinblastine and vincristine, aiming to contribute to the understanding of their mechanism of action and potential side effects. The need for increasing the production of these alkaloids using cost-effective biotechnological methods is also highlighted.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Medicine, Research & Experimental
Barthelemy Diouf, Claudia Wing, John C. Panetta, Donnie Eddins, Wenwei Lin, Wenjian Yang, Yiping Fan, Deqing Pei, Cheng Cheng, Shannon M. Delaney, Wei Zhang, Erik J. Bonten, Kristine R. Crews, Steven W. Paugh, Lie Li, Burgess B. Freeman, Robert J. Autry, Jordan A. Beard, Daniel C. Ferguson, Laura J. Janke, Kirsten K. Ness, Taosheng Chen, Stanislav S. Zakharenko, Sima Jeha, Ching-Hon Pui, Mary V. Relling, M. Eileen Dolan, William E. Evans
Summary: The research discovered a method to enhance the cytotoxic effect of Vincristine on leukemia cells, prolong the survival of mice, while reducing neurotoxicity. This finding may offer a strategy to increase the drug's anticancer effects while minimizing peripheral neuropathy.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Endocrinology & Metabolism
Hui Li, Xiaosong Li, Ying Wang, Hongyou Zhao, Jing Zeng, Yidi Liu, Defu Chen, Shan Long, Wenwen Liu, Jiakang Shao, Haixia Qiu, Ying Gu
Summary: Colorectal cancer (CRC) is effectively treated by photodynamic therapy (PDT) which triggers host immunity to prevent tumor recurrence and metastasis. This study investigated the effect of fluence rate on antitumor immunity of PDT mediated by hematoporphyrin derivatives (HpD) and found a significant impact of fluence rate on PDT-induced immune response.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Kerong Guo, Jian Li, Yingdong Jia, Xiaojuan Yang, Xiqing Yan, Liqiang Wu
Summary: In this study, novel quinolinedione-linked sulfonylpiperazine derivatives were investigated as NQO1-directed antitumor agents. Most of the compounds showed higher effectiveness in inhibiting cancer cell proliferation compared to 5-Fu and TSA. Among them, compound 22r exhibited significant anti-proliferative activity against NQO1-rich cancer cells and was recognized as an excellent substrate for NQO1. Mechanistic studies revealed that 22r induced ROS production, DNA damage, and apoptosis in HepG2 cells. Remarkably, compound 22r also showed excellent anticancer activity in HepG2 xenograft models. Overall, this study demonstrated that compound 22r could be a promising strategy for the treatment of malignant tumors.
BIOORGANIC CHEMISTRY
(2023)
Review
Chemistry, Medicinal
Xianzhang Wang, Yumeng Zhuang, Yuankun Wang, Maokai Jiang, Lei Yao
Summary: This review article summarizes the structural modifications made on camptothecin (CPT), a potent cytotoxic natural alkaloid. The aim of these modifications is to enhance the therapeutic potential of CPT derivatives by improving their efficacy, selectivity, and pharmacokinetic properties. The article reviews the advancements in hybridizing CPT with other bioactive compounds, synthesizing novel CPT analogs, and exploring the structure-activity relationship (SAR) of these modified derivatives.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Laura Grau, Richard Soucek, M. Dolors Pujol
Summary: Resveratrol, a natural compound with antioxidant properties, has potential as both a chemopreventive and cancer chemotherapeutic agent. Due to its poor bioavailability, the study of new derivatives is important. In this study, (E)-stilbenes derived from resveratrol and cyclic analogues with benzofuran or indole nucleus were synthesized and evaluated for their impact on tumor growth. Some compounds showed higher cytotoxicity than (E)-resveratrol, with one derivative demonstrating eight times greater cytotoxic activity against colon cancer cells. Certain cyclic derivatives also exhibited strong inhibition of cell growth.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Dawei Yu, Jiayao Feng, Huimin You, Shipeng Zhou, Yan Bai, Jincan He, Hua Cao, Qishi Che, Jiao Guo, Zhengquan Su
Summary: Chitosan oligosaccharides, derived from abundant marine resources, have been proven to exhibit various biological activities. Their properties can be further enhanced through the formation of different derivatives, making them superior to chitosan itself. This review provides an overview of the key structures and synthesis methods of chitosan oligosaccharide derivatives, as well as discussing their applications in antimicrobial and antitumor fields.
Article
Chemistry, Medicinal
Shuqiang Chen, Kaijian Bi, Shanchao Wu, Yu Li, Yahui Huang, Chunquan Sheng, Guoqiang Dong
Summary: Novel water-soluble derivatives of 10-hydroxyevodiamine were synthesized, showing good antitumor activities, especially phosphate derivative 9. Further studies revealed that compound 9 induced apoptosis through multiple pathways, demonstrating promising antitumor efficacy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Organic
Wesam Abd El-Fattah
Summary: In this study, 1,2,4-triazine derivatives were synthesized and evaluated for their anticancer activities through a series of chemical reactions. The structures of the synthesized derivatives were confirmed, and three compounds showed promising inhibitory growth efficacy against human hepatocellular carcinoma cell lines. This research demonstrates the potential of these compounds as agents against cancer.
LETTERS IN ORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Fernando Duraes, Patricia M. A. Silva, Pedro Novais, Isabel Amorim, Luis Gales, Catia I. C. Esteves, Samuel Guieu, Hassan Bousbaa, Madalena Pinto, Emilia Sousa
Summary: A library of thioxanthones was synthesized, leading to unexpected discovery of four tetracyclic thioxanthenes. Two compounds exhibited potent growth inhibition in human tumor cell lines, with established structure-activity relationship. Photophysical studies revealed dye-like characteristics in some compounds.
Review
Biochemistry & Molecular Biology
Qiuzi Dai, Qinsheng Sun, Xiaorong Ouyang, Jinyang Liu, Liye Jin, Ahao Liu, Binsheng He, Tingting Fan, Yuyang Jiang
Summary: 1,3,5-triazine derivatives, also known as s-triazines, have shown their potential as anticancer agents. Several s-triazine derivatives have been approved for the treatment of refractory ovarian cancer, metastatic breast cancer, and leukemia. This review focuses on the medicinal chemistry of s-triazines and their targeting of topoisomerases, tyrosine kinases, phosphoinositide 3-kinases, NADP+-dependent isocitrate dehydrogenases, and cyclin-dependent kinases in various signaling pathways. It provides a comprehensive summary of the discovery, structure optimization, and biological applications of these s-triazine derivatives as anticancer drugs.
Article
Pharmacology & Pharmacy
Xi-Xi Hou, Long-Fei Mao, Yajie Guo, Chaoxuan Lou, Lan Wang, Rui-Fang Li, Huili Wang, San-Qiang Li, Jian-Xue Yang
Summary: Based on structural modification, novel dolutegravir derivatives containing 1,2,3-triazole moieties with different substituted groups were synthesized. The derivatives exhibited good inhibitory effects on A549 cells, with compounds 4b and 4g being the most effective, showing IC50 values of 8.72 +/- 0.11 mu M and 12.97 +/- 0.32 mu M, respectively. Furthermore, compound 4g induced apoptosis and clonal suppression in A549 tumor cells, activated LC3 signaling pathway to induce autophagy, and activated gamma-H2AX signaling pathway to induce DNA damage in tumor cells.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Jing Yuan, Zhanxiong Liu, Zhenfeng Zhang, Deyue Yan, Wanbin Zhang
Summary: The newly designed and synthesized naphthoquinone phenacylimidazolium derivatives showed promising antitumor activity in vitro, with compound 7m demonstrating significant antiproliferative effects and selectivity, inducing apoptosis through inhibiting survivin expression and activating caspase-3.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Review
Polymer Science
Shuaiqi Gan, Yongzhi Wu, Xu Zhang, Zheng Zheng, Min Zhang, Li Long, Jinfeng Liao, Wenchuan Chen
Summary: Phototherapeutic agent-based phototherapies have been proven to be safe for the treatment of malignant tumors. The main modalities include photothermal therapy and photodynamic therapy. However, the phototoxicity of these therapies limits their clinical application. To improve therapeutic performance and minimize side effects, researchers have focused on developing hydrogel-based phototherapy.
