期刊
MOLECULES
卷 17, 期 3, 页码 3243-3258出版社
MDPI
DOI: 10.3390/molecules17033243
关键词
chitosan; lactic acid; scaffold; biodegradable; biocompatible
资金
- Independent Innovation Foundation of Shandong University, IIFSDU [2009 JC001]
A biodegradable, biocompatible poly(chitosan-g-lactic acid) (PCLA) scaffold was prepared and evaluated in vitro and in vivo. The PCLA scaffold was obtained by grafting lactic acid (LA) onto the amino groups on chitosan (CS) without a catalyst. The PCLA scaffolds were characterized by Fourier Transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The biodegradabilty was determined by mass loss in vitro, and degradation in vivo as a function of feed ratio of LA/CS. Bone marrow mesenchymal stem cell (BMSC) culture experiments and histological examination were performed to evaluate the PCLA scaffolds' biocompatibility. The results indicated that PCLA was promising for tissue engineering application.
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