Article
Biochemistry & Molecular Biology
Takashi Maeda, Fumiko Sekiguchi, Kenji Mitani, Ryosuke Yamagata, Maho Tsubota, Shigeru Yoshida, Atsufumi Kawabata
Summary: Irregular axon regeneration or remodeling may contribute to neuropathic pain after peripheral nerve trauma. PGE2, in combination with IBMX, promotes neuritogenesis and neurite outgrowth in mouse DRG neurons, involving the EP4 receptor/PKA/Cav3.2 pathway. Morphine, an MOR agonist, suppresses PGE2-induced neuritogenesis and/or neurite outgrowth, suggesting its potential in preventing neuropathic pain.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Max Braune, Nico Scherf, Claudia Heine, Katja Sygnecka, Thanigaimalai Pillaiyar, Chiara Parravicini, Bernd Heimrich, Maria P. Abbracchio, Christa E. Mueller, Heike Franke
Summary: The study identified MTK as a stimulator of neurite outgrowth, mediating its effects through GPR17. The combination of MTK with GPR17 agonist significantly inhibited neuronal growth, while MTK alone showed growth-promoting effects comparable with GDNF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Atsushi Kunisaki, Akira Kodama, Masakazu Ishikawa, Takahiro Ueda, Marcio D. Lima, Takeshi Kondo, Nobuo Adachi
Summary: Research has shown that carbon nanotube yarns (cYarn) can promote peripheral nerve regeneration, improving nerve function recovery. A 2% CNT density may be the most effective way to enhance nerve regeneration, providing support for nerve defect repair.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Parth Sandeep, Poonam Sharma, Kanishk Luhach, Neerupma Dhiman, Harsha Kharkwal, Bhupesh Sharma
Summary: Neuron navigator proteins play crucial roles in neurodevelopment and are implicated in various pathological conditions. However, our knowledge about them is limited. Investigating their roles in physiological and pathological processes is a novel field that requires extensive research.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2023)
Article
Cell Biology
Hyo-Jeong Yong, Jong-Ik Hwang, Jae-Young Seong
Summary: This study highlights the critical role of FAM19A1 in neuronal maturation and function by affecting dendritic spine development and neurite arborization, demonstrating its involvement in maintaining neural integrity and connectivity.
Article
Plant Sciences
Jin A. Jung, Heon Joo Lee, Myoung Chong Song, Areum Hwangbo, Ji Yoon Beom, Soo Jung Lee, Dong Jin Park, Ji Hoon Oh, Sang-Jun Ha, Eunji Cheong, Yeo Joon Yoon
Summary: Separating the immunosuppressive activity of FK506 from its neurotrophic activity, two new FK506 analogues were synthesized with a proline substitution, which significantly reduced immunosuppressive activity while retaining neurotrophic activity. This replacement is critical for enhancing neurotrophic activity while reducing strong immunosuppressive activity.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Cell Biology
Justus Schikora, Nina Kiwatrowski, Nils Foerster, Leonie Selbach, Friederike Ostendorf, Frida Pallapies, Britta Hasse, Judith Metzdorf, Ralf Gold, Axel Mosig, Lars Toenges
Summary: Neuronal models of neurodegenerative diseases are extensively studied, with neurite outgrowth being a core feature. A computational assay for high throughput skeletonization was developed and validated, showing strong correlation between manual and automated data annotation. This automated neurite length algorithm is a valuable tool for modeling neurite outgrowth and evaluating therapeutic compounds with high throughput approaches.
Article
Pharmacology & Pharmacy
Mahshid Zarei, Abolghasem Esmaeili, Ali Zarrabi, Atefeh Zarepour
Summary: This research aims to evaluate the effects of combining curcumin with dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) on the neuronal branching morphogenesis of PC12 cells. The results showed that the combination of SPIONs and curcumin improved neural branching and enhanced neurogenesis, suggesting a novel therapeutic approach for neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Benhong Xu, Chuanyue Gao, Huan Zhang, Xinfeng Huang, Xifei Yang, Chen Yang, Wei Liu, Desheng Wu, Jianjun Liu
Summary: The study revealed the important roles of PRDX3 in neurite outgrowth and Alzheimer's disease (AD) development. Knockdown of PRDX3 expression promoted retinoic acid-induced neurite outgrowth and led to dysregulation of multiple proteins.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Yu-pu Liu, Ming-yue Tian, Yi-duo Yang, Han Li, Tian-tian Zhao, Jin Zhu, Fang-fang Mou, Guo-hong Cui, Hai-dong Guo, Shui-jin Shao
Summary: This study found that the level of miR-21 was decreased in serum exosomes from DPN rats. Under high glucose conditions, Schwann cells (SC) proliferation was inhibited and cell apoptosis was increased. The expression of miR-21 in cells and exosomes was downregulated. miR-21 expression and SC-derived exosomes could affect neurite outgrowth through the AKT signaling pathway. This suggests the importance of SC-derived exosomal miR-21 in the regulation of neurite outgrowth under high glucose conditions.
Article
Engineering, Biomedical
Ho-Yin Yuen, Wai-Sze Yip, Suet To, Xin Zhao
Summary: Tissue curvature is a crucial anatomical parameter that affects cell behaviors. This study demonstrates that microcurvature substrates can significantly enhance neural polarity and differentiation, leading to various improvements in neural markers and properties. These findings provide new insights into the design of biomaterials for neural tissue engineering.
BIO-DESIGN AND MANUFACTURING
(2023)
Article
Neurosciences
Flavia Malvestio Sisti, Neife Aparecida Guinaim dos Santos, Lilian do Amaral, Antonio Cardozo dos Santos
Summary: Carvacrol (CARV) is a phytochemical with promising neurotrophic effects in neuronal models, potentially beneficial in treating neurodegenerative and neurological diseases by inducing neurite outgrowth and enhancing neuronal plasticity and bioenergetics.
NEUROTOXICITY RESEARCH
(2021)
Article
Cell & Tissue Engineering
Pierre C. Dromel, Deepti Singh, Eliot Andres, Molly Likes, Motoichi Kurisawa, Alfredo Alexander-Katz, Myron Spector, Michael Young
Summary: The biomaterial-based cell replacement approach using gelatin-hyaluronic acid IPN shows promising potential in enhancing intravitreal retinal cell therapy. It improves cell viability, promotes regeneration, and reduces immune cell response, making it a viable treatment option worth further exploration and application in the future.
NPJ REGENERATIVE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jinbae Yu, Youngsik Woo, Heesun Kim, Sihyeon An, Sang Ki Park, Sung Key Jang
Summary: FMRP is a multifunctional protein encoded by the FMR1 gene, and its deficiency is associated with fragile X syndrome. We discovered that FMRP controls neuronal development by enhancing the translation of 4EBP2, a key downstream regulator. This finding contributes to our understanding of the pathology of fragile X syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Hayley D. D. Ackerman, Glenn S. S. Gerhard
Summary: Increasing evidence supports the neuroprotective role of bile acids in major neurodegenerative disorders. The study focused on the two cellular receptors, FXR and TGR5, and their potential as neurotrophic agents. The results showed that DCA and TGR5 agonism could stimulate neurite outgrowth, suggesting a targetable pathway for promoting neurite growth.
Review
Pharmacology & Pharmacy
Md Ezazul Haque, Mahbuba Akther, Shofiul Azam, In-Su Kim, Yuxi Lin, Young-Ho Lee, Dong-Kug Choi
Summary: In Parkinson's disease, the aggregated alpha-synuclein in Lewy bodies and mitochondrial dysfunction play crucial roles in neurodegeneration, with interactions between aggregated alpha-synuclein and mitochondria potentially leading to neuronal loss, making it an emerging drug target for Parkinson's disease treatment.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Rengasamy Balakrishnan, Duk-Yeon Cho, In-Su Kim, Sang-Ho Seol, Dong-Kug Choi
Summary: Neurological disorders are an important global health issue, and there is a lack of effective treatment options. Alpha- and beta-asarone, secondary metabolites found in plants, show potential neuroprotective effects. They act through multiple mechanisms, including antioxidant, anti-inflammatory, and antiapoptotic effects, making them a promising therapeutic approach for neurodegenerative diseases.
Review
Biochemistry & Molecular Biology
Riya Kulkarni, Akshata Thakur, Hemant Kumar
Summary: Disturbance in the neuronal network can lead to instability in microtubules, hindering intra-axonal transport and making it difficult to reestablish the broken network. Peripheral nervous system neurons have the ability to stabilize microtubules, while central nervous system neurons form growth-incompetent structures. Understanding microtubule dynamics is crucial in developing therapeutic strategies for diseases involving disrupted microtubule networks.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Santimoy Sen, Sheetal Lagas, Abhishek Roy, Hemant Kumar
Summary: Cells rely on a balanced cytoskeleton to maintain cellular integrity and regulate signaling pathways. Dysregulation of the cytoskeleton can lead to various pathological conditions, and targeting cytoskeletal dynamics may provide new therapeutic approaches for these diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Cell Biology
Manjeet Chopra, Ankita Bhagwani, Hemant Kumar
Summary: Endothelial cells and pericytes play important roles in blood vessels, with their interaction crucial for angiogenesis and wound healing. Understanding the surface markers, spatiotemporal association, and signaling pathways associated with traumatic spinal cord injury can lead to the identification of new therapeutic targets and preventive strategies.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Divya Goyal, Hemant Kumar
Summary: Endothelial damage, astrogliosis, microgliosis, and neuronal degeneration are common events after spinal cord injury (SCI). Conventional techniques like 2-dimensional histology and immunohistochemistry (IHC) are used to visualize and detect these events, but advanced imaging methodologies such as two-photon imaging and in vivo chemical and fluorescent protein-expressing viral-tracers offer more advantages in terms of tissue sectioning, 3D reconstructed imaging, and minimal invasiveness. This review discusses the future development of these advanced imaging techniques to explore the fundamental mechanisms after SCI.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Sagar Salave, Suchita Dattatray Shinde, Dhwani Rana, Bichismita Sahu, Hemant Kumar, Rikin Patel, Derajram Benival, Nagavendra Kommineni
Summary: Bone-specific functionalization strategies on liposomes can deliver drugs specifically to the bone surface, reducing the dose and off-target effects of the drug, and thereby reducing its toxicity.
Review
Clinical Neurology
Lahanya Guha, Nidhi Singh, Hemant Kumar
Summary: Cell death is a complex process involving multiple pathways, some of which have been well-studied while others are still being explored. In neurological diseases, impairments in various programmed cell death signaling processes are observed. Spinal cord injury, characterized by the death of neuronal and glial cells, can be influenced by different cell death pathways. A better understanding of the molecular basis of these pathways may enhance neuronal and glial survival, promoting a curative path for spinal cord injury.
Review
Neurosciences
Ayub Mohammed Butt, Vimal Rupareliya, A. Hariharan, Hemant Kumar
Summary: The extracellular matrix (ECM) is a complex network of macromolecules that surround cells in tissues, providing structural support and regulating cellular functions. ECM remodeling is a dynamic process involved in tissue growth, wound healing, and tissue repair. Dysregulated ECM remodeling can lead to the formation of fibrotic and glial scars in CNS injuries.
Review
Cell Biology
Meenal Verma, Manjeet Chopra, Hemant Kumar
Summary: This article reviews the role of EphA4 in neurological diseases and discusses its potential as a therapeutic target for CNS diseases. It also provides an overview of multiple signaling pathways that regulate EphA4-associated biological processes.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Vimal P. Rupareliya, Aditya A. Singh, Ayub Mohammed Butt, A. Hariharan, Hemant Kumar
Summary: Astrocytes, with their diverse populations and functions, play essential roles in regulating CNS physiology and are implicated in various neurological and psychiatric disorders. The heterogeneity of astrocytes in morphology, function, and gene expression contributes to their region-specific functions and interactions with neurons. Further investigation into astrocytic heterogeneity may provide new insights and therapeutic approaches for targeting neurological conditions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Immunology
Dominic J. Acri, Yanwen You, Mason D. Tate, Hande Karahan, Pablo Martinez, Brianne Mccord, A. Daniel Sharify, Sutha John, Byungwook Kim, Luke C. Dabin, Stephanie Philtjens, H. R. Sagara Wijeratne, Tyler J. Mccray, Daniel C. Smith, Stephanie J. Bissel, Bruce T. Lamb, Cristian A. Lasagna-Reeves, Jungsu Kim
Summary: Previous research has shown that genetic heterogeneity plays a crucial role in modeling amyloid accumulation and other phenotypes seen in Alzheimer's disease. However, the mechanisms behind the impact of genetic background on the pathogenicity of tau aggregates remain unknown. This study induced tau aggregation in mice with different genetic backgrounds and conducted RNA sequencing to identify key genes associated with tau seeding and amyloid response. The findings suggest that the genetic context of mice affects the alteration of transcriptome and tau seeding, providing valuable resources for better modeling tauopathy.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Neurosciences
Alisha Vartak, Divya Goyal, Hemant Kumar
Summary: Guidance molecules are essential for neural development, particularly in guiding axons to their target regions during spinal cord development. Defects in these molecules' expression or function can lead to abnormalities in axonal pathfinding, growth cone navigation, axonal branching, and synapse formation, affecting neuronal circuit construction and function after central nervous system traumas such as spinal cord injury (SCI).
Review
Chemistry, Medicinal
Monu Kumar Kashyap, Shubhada V. Mangrulkar, Sapana Kushwaha, Akash Ved, Mayur B. Kale, Nitu L. Wankhede, Brijesh G. Taksande, Aman B. Upaganlawar, Milind J. Umekar, Sushruta Koppula, Spandana Rajendra Kopalli
Summary: Cardiotoxicity is a well-known adverse effect of cancer-related therapy, and it significantly affects patient outcomes and quality of life. The use of antineoplastic drugs to treat colorectal cancers (CRCs) can result in cardiac complications. The mechanisms underlying cardiotoxicity associated with CRC treatment are complex and involve the modulation of various signaling pathways, ultimately damaging cardiac tissue. Therefore, the identification and management of cardiotoxicity associated with CRC drug therapy have become increasingly important.
Review
Pharmacology & Pharmacy
Lahanya Guha, Hemant Kumar
Summary: Spinal cord injury (SCI) is a leading cause of morbidity and mortality worldwide, involving complex mechanisms such as cell death pathways, neurodegeneration, glutaminergic transmission, and inflammation. Current treatment options, including corticosteroids and non-steroidal anti-inflammatory drugs, have limitations in their effectiveness and are focused on symptomatic relief. Drug repurposing offers a promising approach to expand therapy alternatives for SCI, utilizing approved drugs with known safety and efficacy data. This review summarizes marketed drugs that could be repurposed and discusses ongoing clinical trials for SCI therapy.
PHARMACEUTICAL MEDICINE
(2023)