期刊
MOLECULES
卷 17, 期 5, 页码 5339-5345出版社
MDPI
DOI: 10.3390/molecules17055339
关键词
acridinedione; polyhydroquinoline; one-pot reaction; water
资金
- Natural Science Foundation of Anhui Province Education Department [KJ2010B049]
- Anhui Provincial Natural Science Foundation [1208085QB24]
Acridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in refluxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate for the synthesis of polyhydroquinoline derivatives. This is an environmentally friendly and efficient procedure providing good to excellent yields.
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