期刊
MOLECULES
卷 18, 期 1, 页码 167-177出版社
MDPI
DOI: 10.3390/molecules18010167
关键词
Cordyceps sinensis; exopolysaccharide; sulfation; molecular weight; antioxidant activity
资金
- Hong Kong Government UGC (GRF) [PolyU 5028/09P, PolyU 5033/11P]
- School Foundation Financing Project of Jiangsu University [105DG129]
- Open Foundation of Jiangsu Province Key Laboratory of Physical Processing of Agricultural Products [JAPP2010-7]
EPS-1 was an exopolysaccharide produced by the medicinal fungus Cordyceps sinensis (Cs-HK1). In the present study, EPS-1 was sulfated with chlorosulfonic acid (CSA)-pyridine (Pyr) at different volume ratios, yielding four sulfated derivatives, SEPS-1A, B, C and D, with different degrees of substitution (DS: 0.25-1.38) and molecular weights (17.1-4.1 kDa). The sulfation of EPS-1 occurred most frequently at the C-6 hydroxyl groups due to their higher reactivity. In aqueous solution, the native EPS-1 formed random coils or aggregated networks, but the sulfated derivatives formed single helices. The antioxidant activities of the sulfated EPS-1 derivatives for scavenging hydroxyl radicals (center dot OH) and 2,2-azinobis-3-ehtylbenzothiazolin-6-sulfonic acid radicals (ABTS center dot+) were significantly increased with increasing DS and decreasing molecular weight (MW). Sulfation has thus been shown to be an effective and favorable strategy for improving the physico-chemical properties and bioactivities of fungal polysaccharides.
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