期刊
MOLECULES
卷 17, 期 11, 页码 13036-13044出版社
MDPI AG
DOI: 10.3390/molecules171113036
关键词
AICAR; ZMP; AMPK; AMPK activation; fluorinated nucleosides; fluorination; imidazole nucleosides; nucleoside analogues; modified nucleosides
资金
- Polo delle Scienze e delle Tecnologie per la Vita (Progetto FARO, Finanziamento per l'Avvio di Ricerche Originali)
The substitution of a hydroxyl group by a fluorine atom in a potential drug is an efficient reaction that can, in principle, improve its pharmacological properties. Herein, the synthesis of the novel compound 5'-fluoro-5'-deoxyacadesine (5'-F-AICAR), a strict analogue of AICAR that cannot be 5'-phosphorylated to ZMP by cellular kinases, is reported.
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