Review
Biochemistry & Molecular Biology
Jia Ling Tsong, Lucky Poh Wah Goh, Jualang Azlan Gansau, Siew-Eng How
Summary: N. lappaceum and N. ramboutan-ake, tropical fruits rich in antioxidants and important chemical components, have potential health benefits in protecting against diseases and promoting overall health.
Article
Chemistry, Inorganic & Nuclear
Ramachandran Vinayagam, Kyung Eun Lee, Ernest David, Muhammad Nurul Matin, Sang Gu Kang
Summary: A novel wedelolactone-loaded poly-lactic-co-glycolic acid nanoparticle was synthesized and showed significant antibacterial and anticancer properties. The nanoparticles exhibited stable spherical shape with a surface charge of -33.0 mV, and effective inhibition of bacterial growth and breast cancer cell proliferation.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Environmental Sciences
Wonhyoung Park, Whasun Lim, Gwonhwa Song
Summary: The study showed that Fipronil can reduce the viability of porcine trophectoderm and luminal epithelial cells, induce cell cycle arrest and apoptotic cell death, and affect cell migration and implantation ability. Furthermore, it was observed that Fipronil can alter the PI3K-AKT and MAPK-ERK1/2 signal transduction pathways in the treated cells.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Wonhyoung Park, Garam An, Whasun Lim, Gwonhwa Song
Summary: The study demonstrates that iprodione exhibits cytotoxic effects on porcine trophectoderm and luminal epithelium cells, inhibiting cell viability, proliferation, and migration, and impairing the implantation process.
Review
Biochemistry & Molecular Biology
Yingqian Zhang, Chenyuan Wu, Nana Zhang, Rui Fan, Yang Ye, Jun Xu
Summary: Pyrazole derivatives, a class of heterocyclic compounds, possess unique chemical structures and exhibit a broad spectrum of pharmacological activities. Recent studies have focused on synthesizing and evaluating pyrazole derivatives for their anticancer potential. Structure-activity relationship studies have shown that appropriate substitution on the pyrazole ring can enhance anticancer efficacy and selectivity. Furthermore, these derivatives have demonstrated multiple mechanisms of anticancer action, making them promising candidates for developing anticancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Sandra Ramos-Inza, Ignacio Encio, Asif Raza, Arun K. Sharma, Carmen Sanmartin, Daniel Plano
Summary: The study reported the cytotoxic effects of novel Se-NSAID analogs, showing that compounds 4a and 4d exhibit potential as chemotherapeutic drugs for breast cancer by inducing apoptosis and releasing the parent NSAID along with the Se fragment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Immunology
Maryam Keshtvarz, Ehsan Rezaei, Jafar Amani, Mohammad Reza Pourmand, Jafar Salimian, Sheila Sarial, Masoumeh Douraghi
Summary: Immunotoxins, a type of targeted therapy, can kill cells using highly potent bacterial, fungal or plant toxins. In this study, a Stx-based immunotoxin was designed and used to selectively induce cytotoxicity and apoptosis in Fn-14-positive cells related to colon and lung cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Vimi Kshetrimayum, Rameshwari Heisnam, Ojit Singh Keithellakpam, Pullapanthula Radhakrishnanand, Sai Jyothi Akula, Pulok K. Mukherjee, Nanaocha Sharma
Summary: Paris polyphylla Sm. (Melanthiaceae) is an important and vulnerable herb with a wide range of traditional applications. The extract of P. polyphylla (PPE) showed good antioxidant activity and cytotoxicity against HCT-116 colon cancer cells without significant toxicity to normal cells. PPE also exhibited synergistic effects with 5FU and cisplatin in HCT-116 cells. The anticancer activities of PPE were attributed to its steroidal saponins.
Article
Food Science & Technology
Nadia Perez-Fuentes, Rebeca Alvarin, Amparo Alfonso, Jesus Gonzalez-Jartin, Sandra Gegunde, Mercedes R. Vieytes, Luis M. Botana
Summary: The study revealed that individual mycotoxins had the most damaging effects on neuronal cells, while non-regulated mycotoxins induced apoptosis by affecting mitochondrial membrane potential. Antagonistic effects were observed in all cases when regulated and non-regulated mycotoxins were combined in binary mixtures.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Amal A. M. Eissa, Kholoud F. M. Aljamal, Hany S. Ibrahim, Heba Abdelrasheed Allam
Summary: The study synthesized pyridopyrimidin derivatives and evaluated their effectiveness as EGFR inhibitors. Six compounds showed higher inhibitory activity, while two compounds were similar to the reference drug. Further investigation was conducted on the cytotoxicity and mechanisms of action of four compounds, indicating the most potent inhibitory activity and high cytotoxicity.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Amanda Virtuoso Jacques, Natalia Marceli Stefanes, Laura Otto Walter, Daiane Mari Perondi, Fernanda da Luz Efe, Luiz Felipe Schmitz de Souza, Larissa Sens, Stephanie Milis Syracuse, Ana Carolina Rabello de Moraes, Aldo Sena de Oliveira, Carolina Teixeira Martins, Luma Godoy Magalhaes, Adriano Defini Andricopulo, Lisandra de Oliveira Silva, Ricardo Jose Nunes, Maria Claudia Santos-Silva
Summary: The study found that chalcones F07, F09, and F10 exhibit cytotoxicity against K562 and Jurkat cells, induce apoptosis, and do not affect the functionality of other human cells.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Guo-Kai Wang, Yun-Peng Sun, Wen-Fang Jin, Yang Yu, Jian-Yong Zhu, Jin-Song Liu
Summary: Sixteen new limonoids and 18 known limonoids were isolated from Swietenia macrophylla, and their structures were determined. Limonoid 19 exhibited significant cytotoxic effects against A375 cells and induced apoptosis.
BIOORGANIC CHEMISTRY
(2022)
Article
Food Science & Technology
Maria Julia Martinez, Adriana Balbina Andreu, Luciana Barbini
Summary: Hepatocellular carcinoma (HCC) is a common and deadly tumor. Late diagnosis and treatment delay contribute to poor prognosis. Polyphenols from potatoes have antioxidant properties and cytotoxic effects on HCC cells, making them a potential treatment option.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Qinglian Hu, Liwang Xu, Xiaoyu Huang, Yuxuan Duan, Dongchang Sun, Zhengwei Fu, Yunfen Ge
Summary: In this study, a collaborative MOF system with dual-response properties was constructed for intelligent drug release. The system demonstrated excellent biocompatibility and synergistic efficacy, showing promising potential for biomedical applications.
Article
Pharmacology & Pharmacy
Enas Alaa El-din Abd El-aziz, Sherif Farouk Elgayar, Fatma M. Mady, Mohammed A. S. Abourehab, Omiya Ali Hasan, Lamis M. Reda, Eman Alaaeldin
Summary: This study evaluated the use of liposomes as a drug delivery system to enhance the cytotoxic effect of propolis on squamous cell carcinoma cell lines. The findings showed that propolis liposomes significantly increased apoptosis in Hep-2 cells, indicating that liposomes are a powerful tool for enhancing the cytotoxicity of propolis.
Review
Food Science & Technology
Ting Yi Heung, Jessica Yue Shuen Huong, Wan Yeng Chen, Yi Wen Loh, Kooi Yeong Khaw, Bey-Hing Goh, Yong Sze Ong
Summary: Papaya extracts or their bioactive compounds may serve as a potential broad-spectrum therapy for cancer by targeting multiple characteristics of cancer development.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Biology
Shereen Lai Shi Min, Sook Yee Liew, Nelson Jeng Yeou Chear, Bey Hing Goh, Wen-Nee Tan, Kooi Yeong Khaw
Summary: Plant-derived terpenes have shown potential as cholinesterase inhibitors, making them a promising target for the treatment of Alzheimer's disease. Various terpenoids have been found to inhibit cholinesterase activity, with their chemical structures playing a role in this inhibition. This research encourages further exploration of terpenes for drug discovery and development in treating Alzheimer's disease.
Article
Engineering, Environmental
Janarthanan Supramaniam, Darren Yi Sern Low, See Kiat Wong, Bey Fen Leo, Bey Hing Goh, Siah Ying Tang
Summary: This study successfully fabricates rubber gloves with excellent mechanical properties and self-healing ability by synthesizing zinc oxide-cellulose nanofiber (ZnO-CNF) reinforced epoxidized natural rubber (ENR) composite. The addition of ZnO-CNF filler significantly improves the tensile strength and thermal stability of the gloves. The resulting ENR/ZnO-CNF gloves exhibit high strength, strain recovery, and thermo-responsive self-healing behavior.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Environmental Sciences
Thiviya Darmarajan, Keshav Raj Paudel, Mayuren Candasamy, Jestin Chellian, Thiagarajan Madheswaran, Lakshmana Prabu Sakthivel, Bey Hing Goh, Piyush Kumar Gupta, Niraj Kumar Jha, Hari Prasad Devkota, Gaurav Gupta, Monica Gulati, Sachin Kumar Singh, Philip Michael Hansbro, Brian Gregory George Oliver, Kamal Dua, Dinesh Kumar Chellappan
Summary: This review article aims to establish an understanding of the relationship between autoimmune conditions and COVID-19 infections. Studies have suggested a correlation between COVID-19 and autoimmune diseases, with the SARS-CoV-2 virus potentially triggering autoimmune conditions. The review also discusses promising therapeutic strategies for regulating autoimmune conditions in the future.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Food Science & Technology
Omar Belmehdia, Naoual El Menyiy, Abdelhakim Bouyahya, Aicha El Baaboua, Nasreddine El Omari, Monica Gallo, Domenico Montesano, Daniele Naviglio, Gokhan Zengin, Nadia Skali Senhaji, Bey Hing Goh, Jamal Abrini
Summary: This review discusses the recent advances in the chemical composition and biological activities of propolis. It highlights the various important bioactive properties of propolis, including antibacterial, antioxidant, and anticancer effects. Data shows that propolis has low toxicity even at high doses, making it a promising source of bioactive compounds for drug development.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Pathology
Kar-Yan Su, Jie-Yi Koh Kok, Yie-Wei Chua, Shearn-Dior Ong, Hooi Leng Ser, Priyia Pusparajah, Pui San Saw, Bey Hing Goh, Wai-Leng Lee
Summary: Extracellular vesicles (EVs) are membrane-derived lipid bilayers released by cells. Bacterial EVs (BEVs) have attracted interest as potential diagnostic markers due to their differential bacterial composition in biofluids between patients and healthy controls. This review outlines the commonly used approach for investigating BEVs in biofluids, including 16S ribosomal RNA gene sequencing, and discusses the potential of BEVs as biomarkers for various diseases.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Review
Nutrition & Dietetics
Shu Chyi Wong, Muhamad Noor Alfarizal Kamarudin, Rakesh Naidu
Summary: High-grade adult-type diffuse gliomas are the most common and deadliest malignant adult tumors of the central nervous system. Introducing dietary flavonoids to the current high-grade adult-type diffuse glioma treatment strategies is crucial to overcome the challenge of intra-tumor heterogeneity. Flavonoids have the potential to target multiple molecules associated with high-grade adult-type diffuse glioma cell proliferation, apoptosis, oxidative stress, and other key processes.
Review
Medicine, General & Internal
Le-Wei Wong, Siow-Hui Mak, Bey-Hing Goh, Wai-Leng Lee
Summary: In conjunction with imaging analysis, pathology-based assessments of biopsied tissue are the gold standard for diagnosing solid tumors. However, the disadvantages of tissue biopsies have led to the development of liquid biopsy, which involves sampling and clinical assessment of bodily fluids for cancer diagnosis. Extracellular vesicles (EVs), carrying molecular profiles of their cell or tissue origins, have emerged as one of the most promising biomarkers for cancer, allowing for non-invasive and rapid diagnosis with the help of Fourier-transform infrared spectroscopy (FTIR).
Article
Health Care Sciences & Services
Qais Jarrar, Rami Ayoub, Kawther Alhussine, Khang Wen Goh, Said Moshawih, Chrismawan Ardianto, Bey Hing Goh, Long Chiau Ming
Summary: This study aimed to investigate the behavioral effects of prolonged maternal separation (MS) in the offspring of mice. The results showed that prolonged MS caused the adult offspring to exhibit anxiolytic-like behaviors and increased compulsive burying activity.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Fatemeh Shahdadi, Maliheh Faryabi, Haroon Khan, Ali Salehi Sardoei, Bahman Fazeli-Nasab, Bey Hing Goh, Khang Wen Goh, Ching Siang Tan
Summary: This study examined the antibacterial effects of Mentha longifolia essential oil and pulegone in edible coatings on the growth of Staphylococcus aureus, Listeria monocytogenes, and Escherichia coli in cheese. The results showed that the addition of these compounds significantly reduced bacterial growth during storage. Increasing the concentration of chitosan, M. longifolia, and pulegone in the coatings further decreased the bacterial population, with pulegone exhibiting a stronger effect. Overall, the findings suggest that M. longifolia essential oil and pulegone, combined with alginate and chitosan coatings, have antibacterial effects against S. aureus, L. monocytogenes, and E. coli in cheese.
Article
Medicine, General & Internal
Najwa Hazwani Muhammad Haskani, Long Chiau Ming, Jagjit Singh Dhaliwal, Daniel Vui Teck Wee, Bey Hing Goh, Majid Ali, Shazwani Shaharuddin, Khang Wen Goh, Hui Poh Goh
Summary: This study aimed to identify and review research related to the practice of patients with DM in Brunei Darussalam in order to identify associated factors influencing diabetic medication knowledge and adherence. The results revealed relatively poor medication knowledge and inappropriate diabetes-related practices in studies conducted in Brunei Darussalam. However, no study has directly measured both medication awareness and compliance among Brunei Darussalam T2DM patients. Future studies can focus on the relation between these two factors in different geographical locations characterized by different diabetes-related practices and culture.
PATIENT PREFERENCE AND ADHERENCE
(2023)
Editorial Material
Pharmacology & Pharmacy
Kah Hui Wong, Lee Wei Lim, Nur Shahirah Mohd Hisam, Muhamad Noor Alfarizal Kamarudin, Hariprasath Lakshmanan
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biology
Brandon Wee Siang Phon, Saatheeyavaane Bhuvanendran, Qasim Ayub, Ammu Kutty Radhakrishnan, Muhamad Noor Alfarizal Kamarudin
Summary: This study investigated the suitability of 3D cultures as cell-based models for GBM by leveraging genomic data. Genes related to pathways such as epithelial-to-mesenchymal transition, angiogenesis/migration, hypoxia, stemness, and the Wnt signalling pathway were found to be upregulated in both brain samples from GBM patients and 3D GBM cells. These findings support the use of 3D GBM cultures as reliable preclinical models for studying GBM.
Review
Biology
Dexter Hoi Long Leung, Brandon Wee Siang Phon, Mageswary Sivalingam, Ammu Kutty Radhakrishnan, Muhamad Noor Alfarizal Kamarudin
Summary: In this scoping review, we identified a range of lncRNAs that play a regulatory role in GBM cells by modulating EMT markers, transcription factors, and the affiliated signalling pathways associated with MES transition. These findings provide an update on the complex interplays between lncRNAs, EMT markers, TFs, and signalling pathways in GBM cell studies.
Article
Biochemistry & Molecular Biology
Wei Hsum Yap, Bey Hing Goh
