Article
Environmental Sciences
Hanying Hu, Haoran Sun, Jinghui Wu, Jiayi Liu, Hong Jin, Ke Tao
Summary: The expansion of Stellera chamaejasme L. on the Qinghai-Tibet Plateau significantly affects soil nutrient composition and changes the structure of the rhizosphere soil bacterial community. The heavy expansion of Stellera chamaejasme L. reduces bacterial diversity and alters the beta diversity of the bacterial community. Furthermore, the expansion enriches bacterial communities involved in carbon and nitrogen metabolism and promotes plant growth. These findings contribute to understanding and proposing effective restoration measures for grassland degradation caused by poisonous weed invasion.
LAND DEGRADATION & DEVELOPMENT
(2023)
Article
Biochemistry & Molecular Biology
Kang Ding, Zi-Yao Wu, Nuan Zhang, Jun He, Fan Zhang, Jing-Jing Wu, Hong-Jin Bai, Wei-Ku Zhang, Lin Li, Jie-Kun Xu
Summary: Six undescribed macrocyclic daphnane orthoesters, stelleratenoids A-F (1-6), were obtained from the roots of Stellera chamaejasme L. Their structures were determined using extensive spectroscopic analyses. Compound 1 exhibited an unusual terminal double bond, while compounds 2-4 had different long chain fatty acyl groups and compounds 5 and 6 were modified macrocyclic daphnane diterpenoids. Compounds 1, 5, and 6 showed potent anti-HIV activity, indicating potential for the development of new anti-HIV drugs.
Article
Biochemistry & Molecular Biology
Zhuo-Yang Cheng, Jing-Xian Ren, Xiao-Bian Xue, Man Wang, Xiao-Qi Yu, Bin Lin, Guo-Dong Yao, Shao-Jiang Song, Xiao-Xiao Huang
Summary: In this study, the phytochemical components in the root extracts of Stellera chamaejasme L. were analyzed, leading to the discovery of three new daphnane-type diterpenoids (steller-adaphnanes A-C) and 15 known analogues. Compound 3 exhibited potent growth-inhibitory activities against HepG2 and Hep3B cells.
Article
Biochemistry & Molecular Biology
Qi Song, Shi-Fang Li, Zhuo-Yang Cheng, Shao-Jiang Song, Xiao-Xiao Huang
Summary: Fifteen compounds were isolated from the roots of Stellera chamaejasme L., including six lignans (1-6), one coumarin (7), five diarylpentanes (8-12), two penylpropanoids (13-14), and one alkaloid (15). The structures of these compounds were determined by extensive spectroscopic methods and comparison with literature data. This study provides the first report on the occurrence of certain compounds in the Thymelaeaceae family and Stellera genus, highlighting the importance of taxonomy in identifying plant species.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Juan Wu, Zhujun Ye, Caicen Liao, Rongtao Li, Xuanqin Chen, Akihito Yokosuka
Summary: An undescribed diterpene, stellerterpenoid A, and two undescribed sesquiterpenoids, stellerterpenoids B and C, were isolated from the roots of Stellera chamaejasme L. Six known compounds were also identified. Among them, stellerterpenoid A was a rare 13, 14-seco nortigliane diterpenoid and stellerterpenoid B was a guaiacane-type sesquiterpenoid with an unusual 1, 2-diketone moiety. The known compound stelleraguaianone B exhibited moderate activity for suppressing NO production in LPS-treated RAW 264.7 macrophages cells. None of the compounds showed anti-influenza virus or anti-tumor activity in vitro.
Article
Biochemistry & Molecular Biology
Jun Pan, Jun-Cheng Su, Yi-Hui Liu, Bin Deng, Zhuo-Fan Hu, Jia-Le Wu, Ru-Feng Xia, Chen Chen, Qian He, Jia-Chun Chen, Luo-Sheng Wan
Summary: Thirteen new guaiane-type sesquiterpenoids were isolated from the roots of Stellera chamaejasme, among which compound 14 showed significant cytotoxic effect against Du145 cell line by promoting cell apoptosis and inhibiting cell proliferation.
BIOORGANIC CHEMISTRY
(2021)
Article
Agronomy
Hui Jin, Hongru Guo, Xiaoyan Yang, Aiyi Xin, Haoyue Liu, Bo Qin
Summary: The study investigated the interactions between allelochemicals, soil enzyme activities, environmental factors, and rhizosphere bacterial communities of Stellera chamaejasme in the northern Tibetan Plateau, suggesting their influence on the composition and diversity of rhizosphere soil bacterial communities.
ARCHIVES OF AGRONOMY AND SOIL SCIENCE
(2022)
Article
Biology
Temuulen Selenge, Sara F. Vieira, Odontuya Gendaram, Rui L. Reis, Soninkhishig Tsolmon, Enkhtuul Tsendeekhuu, Helena Ferreira, Nuno M. Neves
Summary: In this study, the ethanol and dichloromethane extracts of Stellera chamaejasme were evaluated for their antioxidant and anti-inflammatory activities. The ethanol extract of the aerial parts contained flavonoid compounds, while the root extracts and dichloromethane extract did not. The extracts exhibited strong antioxidant activity and efficiently inhibited the production of pro-inflammatory cytokines. Particularly, the dichloromethane extract of the root showed the strongest activity and contained fatty acids and triterpenoids.
Article
Biochemistry & Molecular Biology
Fang-Yu Yuan, Zhuo-Ya Tang, Xue-Long Yan, Dong Huang, Han-Zhuang Weng, Jia-Luo Huang, Run-Zhu Fan, Ye Chen, Sheng Yin, Gui-Hua Tang
Summary: In this study, 20 sesquiterpenoids of four different types were isolated from the 95% ethanol extract of Stellera chamaejasme roots, including six previously undescribed ones. The structures and absolute configurations of these compounds were elucidated, and their neuroprotective effects on cell damage were evaluated.
Article
Plant Sciences
Zhuo-Yang Cheng, Shi-Fang Li, Qi Song, Ning-Ning Du, Shao-Jiang Song, Xiao-Xiao Huang
Summary: Chemical investigation of Stellera chamaejasme roots led to the discovery of five previously unidentified compounds, including three lignans (1, 2, and 3b), one coumarin (4), one diarylpentanoid (5), and eight known analogues (3a, 6-10, and 11a/11b). Chiral resolution successfully separated two pairs of enantiomers. The structures of all compounds were confirmed through NMR spectroscopy, HRESIMS data analysis, quantum chemical calculations, and single-crystal X-ray diffraction analyses. Compound 2 exhibited the strongest inhibitory activity against AChE, with an inhibition rate of 88.0% at 100 mu M. Molecular docking predicted the possible interaction mechanism of compound 2 with AChE.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Plant Sciences
Bo Zhang, Shu-Fan Sun, Wang-Long Luo, Jia-Xin Li, Qiang-En Fang, De-Gang Zhang, Gui-Xin Hu
Summary: The adult thrips of Frankliniella intonsa and the host Stellera chamaejasme interact mutually to contribute to each other's fitness, with the thrips pollinating host plants and the plants providing the insects with breeding sites and food. The thrips preferentially forage in half-flowering inflorescences and oviposit in floral tubes, and the floral longevity precisely accommodates the thrips life cycle. Excluding adult thrips from foraging flowers results in a significant decrease in host plant fitness and thrips fecundity in the flowers.
Article
Biochemistry & Molecular Biology
Zhuo-Yang Cheng, Zi-Lin Hou, Jing-Xian Ren, Ding-Ding Zhang, Bin Lin, Xiao-Xiao Huang, Shao-Jiang Song
Summary: Nine undescribed guaiane-type sesquiterpenoids, known as stelleraterpenoids A-I, were isolated from the roots of Stellera chamaejasme L. along with seven reported congeners. The compounds showed neuroprotective effects on H2O2-induced damage in human neuroblastoma SH-SY5Y cells. Stelleraguaianone B exhibited the best activity in inhibiting cell apoptosis compared to the positive control Trolox.
Article
Microbiology
Wenting Tang, Weijun Gong, Ruitong Xiao, Wenqin Mao, Liangzhou Zhao, Jinzhao Song, Muhammad Awais, Xiuling Ji, Haiyan Li
Summary: The endophytic fungal community of Stellera chamaejasme was studied and it was found that the roots had a greater number of specific types of endophytic fungi compared to the shoots. The tested isolates showed plant-growth-promoting activities, and the Aspergillus niger isolate exhibited the best growth-promotion effect on the host plants.
Article
Biochemistry & Molecular Biology
Xiao-Qi Yu, Qiu-Lin Yan, Shuai Shen, Zhuo-Yang Cheng, Xiao-Xiao Huang, Guo-Dong Yao, Shao-Jiang Song
Summary: The study found that the biflavone CE from Stellera chamaejasme root exhibited strong inhibitory effects against HCC Hep3B cells. This inhibition may be achieved by targeting c Met. CE also suppressed cell proliferation, colony formation, and migration ability of HCC cells, and showed efficacy without toxicity in a tumor xenograft model.
BIOORGANIC CHEMISTRY
(2022)
Article
Plant Sciences
Lizhu Guo, Li Liu, Huizhen Meng, Li Zhang, Valdson Jose Silva, Huan Zhao, Kun Wang, Wei He, Ding Huang
Summary: This study examines the leaf stoichiometry of Stellera chamaejasme and its relationship with environmental variables, particularly in the Inner Mongolian Plateau and Qinghai-Tibet Plateau in Northern China. The results suggest that the nutrient concentrations and stoichiometry of S. chamaejasme are not strongly affected by soil physicochemical properties, indicating their broad distributions in China's grasslands. Furthermore, the study shows that S. chamaejasme exhibits strong adaptation in terms of carbon and nitrogen contents, while phosphorus and potassium contents show regional differences.