期刊
MOLECULES
卷 16, 期 6, 页码 4937-4957出版社
MDPI
DOI: 10.3390/molecules16064937
关键词
1,2,4-triazinone; thiadiazinone; triazinone; triazine carbonitrile; microwave synthesis
资金
- Taif University, Taif, KSA [1/431/727]
Rapid and efficient solvent-free synthesis of 4-amino-3-mercapto-6-[2-(2-thienyl) vinyl]-1,2,4-triazin-5(4H)-one 1 under microwave irradiation is described. Some new fused heterobicyclic nitrogen systems such as 1,2,4-triazino[3,4-b][1,3,4] thiadiazinones, 1,3,4-thiadiazolo[2,3-c][1,2,4] triazinone and pyrazolo[5,1-c][1,2,4] triazine-7-carbonitrile, have been synthesized by treatment of 1 with bifunctional oxygen and halogen compounds, CS2/KOH and malononitrile via heterocyclization reactions, in addition to some uncondensed triazines. Structures of the products have been deduced from their elemental analysis and spectral data (IR, H-1-NMR, C-13-NMR). Select new synthesized compounds were screened as anticancer agents, with some showing activity as cytotoxic agents against different cancer cell lines.
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