Review
Plant Sciences
Ingrid Borges Siqueira, Yvanna Louise Di Christine Oliveira, Sona Jain, Audrey Rouse Soares Tavares Silva, Luiz Fernando de Jesus Nascimento, Marcio Luiz da Gama Lisboa, Tiago Branquinho Oliveira, Damiao Pergentino de Sousa, Ana Andrea Teixeira Barbosa, Silvio Santana Dolabella
Summary: This review discusses the leishmanicidal activity of essential oils and their major compounds extracted from native Brazilian plants. The study shows that these plant species from different regions of Brazil have potential activity against different forms of Leishmania. However, further confirmation of these results in animal models is necessary.
PHYTOCHEMISTRY REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Jiyoon Yang, Su-Yeon Lee, Soo-Kyeong Jang, Ki-Joong Kim, Mi-Jin Park
Summary: This study investigated the anti-inflammatory effects of various citrus cultivars and their active anti-inflammatory components. The essential oils from Citrus japonica and Citrus maxima exhibited superior anti-inflammatory activities, and α-terpineol was identified as an active anti-inflammatory compound.
Article
Biochemistry & Molecular Biology
Celeste de Jesus Pereira Franco, Oberdan Oliveira Ferreira, Jorddy Neves Cruz, Everton Luiz Pompeu Varela, Angelo Antonio Barbosa de Moraes, Lidiane Diniz do Nascimento, Marcia Moraes Cascaes, Antonio Pedro da Silva Souza Filho, Rafael Rodrigues Lima, Sandro Percario, Mozaniel Santana de Oliveira, Eloisa Helena de Aguiar Andrade
Summary: This study analyzed the chemical composition of Calycolpus goetheanus specimens' essential oils and evaluated their phytotoxic and antioxidant activities, as well as the interaction mode with a molecular binding protein through molecular docking.
Review
Food Science & Technology
Jiali Ji, Shiv Shankar, Fiona Royon, Stephane Salmieri, Monique Lacroix
Summary: Meat and meat products are prone to microbial and pathogen growth, leading to economic loss and health hazards. Natural preservatives such as essential oils (EOs), especially thyme, cinnamon, rosemary, and garlic, have shown strong antimicrobial activity. Encapsulation of EOs in wall materials improves their stability and antimicrobial ability in meat products.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Meilin Li, Shenrui Feng, Siyi Huang, Jacques Guillot, Fang Fang
Summary: This study evaluated the efficacy of six components against scabies infections caused by Sarcoptes scabiei. Carvacrol showed the highest miticidal efficacy, followed by eugenol, geraniol, citral, terpinen-4-ol, and linalool. Carvacrol, eugenol, and geraniol have the potential to be complementary or alternative agents for Sarcoptes scabiei infections in humans or animals. This study provides a scientific basis for the development of scabicidal products based on essential oils.
Review
Horticulture
Maria Michela Salvatore, Rosario Nicoletti, Anna Andolfi
Summary: Citrus essential oils are widely used in the food, pharmaceutical, cosmetical, and chemical industries. They play a crucial role in the quality of citrus fruits by providing natural protection against postharvest deteriorations. Various factors influence the assortment and accumulation of essential oils in citrus peels, which have implications for the postharvest quality of the fruit.
Article
Plant Sciences
Natalia de Matos Balsalobre, Elisangela Dos Santos, Sidney Mariano Dos Santos, Arielle Cristina Arena, Elisabete Castelon Konkiewitz, Edward Benjamin Ziff, Anelise Samara Nazari Formagio, Candida Aparecida Leite Kassuya
Summary: The aim of this study was to investigate the analgesic and anti-arthritic properties of EOAE and viridiflorol using in vivo models.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Parasitology
Meilin Li, Shunlong Liu, Zhijuan Yin, Charlotte Bernigaud, Jacques Guillot, Fang Fang
Summary: This study assessed the activity of six terpenes commonly found in essential oils against Sarcoptes scabiei eggs, with carvacrol, eugenol, and geraniol showing significant ovicidal activities. The results suggest these compounds could be promising agents for scabies treatment.
PARASITES & VECTORS
(2021)
Review
Biochemistry & Molecular Biology
Ernesto R. Soto, Florentina Rus, Zeynep Mirza, Gary R. Ostroff
Summary: This review discusses the encapsulation methods of terpenes and essential oils using yeast particles (YPs) as carriers. These methods provide high payload loading capacity and efficiency, as well as stability and sustained-release properties, making them suitable for various agricultural, food, and pharmaceutical applications.
Review
Plant Sciences
Giuseppe De Mastro, Jihane El Mahdi, Claudia Ruta
Summary: Weeds are the most expensive pest to manage in all farming systems, with organic farming facing additional challenges due to restrictions on herbicides. Research is focusing on using allelopathic compounds from plants, particularly from the Lamiaceae family, as bioherbicides. Developing effective bioherbicides from essential oils of Mediterranean Lamiaceae plants remains challenging.
Review
Plant Sciences
Trifone D'Addabbo, Pinarosa Avato
Summary: Essential oils can be a valuable source of new food-safe and healthy nematicidal products due to their strong activity on crop pathogens and pests, as well as their low environmental persistence. Testing 16 different essential oils from various botanical origins and compositions revealed that most of them are highly suitable for formulating new safe nematicides.
Review
Biochemistry & Molecular Biology
Sergio A. Ojeda-Piedra, Maria L. Zambrano-Zaragoza, Ricardo M. Gonzalez-Reza, Claudia Garcia-Betanzos, Samantha A. Real-Sandoval, David Quintanar-Guerrero
Summary: This article investigates the application of nano-encapsulated essential oils in meat preservation and analyzes their effectiveness. The disadvantages of using essential oils, including their intense flavor, degradation under certain environmental conditions, and low solubility in water, can be addressed through nano-encapsulation.
Article
Environmental Sciences
Shadia Angulo-Milhem, Marie Verriele, Melanie Nicolas, Frederic Thevenet
Summary: The study evaluated the emissions of essential-oils in confined environments, finding that the concentration levels and duration of diffusion vary depending on the diffusion mechanism.
ATMOSPHERIC ENVIRONMENT
(2021)
Article
Plant Sciences
Jiayi Liu, Juan Hua, Bo Qu, Xuanyue Guo, Yangyang Wang, Meini Shao, Shihong Luo
Summary: This study identified twenty terpenes from Artemisia nakaii essential oils, with monoterpenes and sesquiterpenes showing strong fumigant toxicity and antifeedant activity against Spodoptera litura larvae. Monoterpenes like 1,8-cineole and (+)-camphor displayed significant fumigant activity, while sesquiterpenes like feropodin and beta-selinene showed noticeable antifeedant activity. The essential oils and beta-selinene also inhibited acetylcholinesterase, indicating their potential use as botanical pesticides against S. litura.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biophysics
Luis H. de Oliveira, Pollyana Trigueiro, Joao Sammy Nery Souza, Marinaldo S. de Carvalho, Josy A. Osajima, Edson C. da Silva-Filho, Maria G. Fonseca
Summary: Essential oils are natural mixtures used for various purposes but are hindered by volatility. Studies show that combining them with clay minerals can create new materials with antibacterial and insecticidal properties.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Camila Bomfim de Sa, Andressa Brito Lira, Abrahao Alves de Oliveira Filho, Kardilandia Mendes de Oliveira, Alexandre Rolim da Paz, Mayara Castro de Morais, Damiao Pergentino de Sousa, Gabriela Tafaela Dias, Cinthia Rodrigues Melo, Hilzeth de Luna Freire Pessoa, Caliandra Maria Bezerra Luna Lima, Margareth de Fatima Formiga Melo Diniz
Summary: The authors certify their contributions to the manuscript and conducted various tests to verify the antioxidant activity and toxicity profile of ethyl ferulate. The study findings provide important information for the safe use of this compound in the future.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yunierkis Perez-Castillo, Ricardo Carneiro Montes, Cecilia Rocha da Silva, Joao Batista de Andrade Neto, Celidarque da Silva Dias, Allana Brunna Sucupira Duarte, Helio Vitoriano Nobre Junior, Damiao Pergentino de Sousa
Summary: This study synthesized cinnamic and benzoic acid amides and tested their inhibitory effects against Candida strains. Compound 16 showed strong antifungal activity and a potential multi-target mechanism of action, involving proteins related to critical cellular processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Hasan Turkez, Mehmet Enes Arslan, Joice Nascimento Barboza, Cigdem Yuce Kahraman, Damiao Pergentino de Sousa, Adil Mardinoglu
Summary: Alzheimer's Disease is a major neurodegenerative disease with no definitive treatment. However, ferulic acid and its derivatives, as antioxidants, show promising potential for the treatment of Alzheimer's Disease.
CURRENT DRUG DELIVERY
(2022)
Article
Chemistry, Medicinal
Pablo Rayff da Silva, Natalia Diniz NunesPazos, Thallita Karla Silva do Nascimento Gonzaga, Jessica Cabral de Andrade, Alefe Brito Monteiro, Anne Caroline Ribeiro Portela, Hugo Fernandes Oliveira Pires, Mayara Dos Santos Maia, Diogo Vilar da Fonseca, Marcus T. Scotti, Jose Maria Barbosa Filho, Damiao Pergentino de Sousa, Cicero Francisco Bezerra Felipe, Reinaldo Nobrega de Almeida, Luciana Scotti
Summary: This study evaluated the potential of the monoterpene tetrahydrolinalool as an anxiolytic and antidepressant through in vivo animal models and molecular docking. Results showed that tetrahydrolinalool at appropriate doses effectively reduced anxiety and depression symptoms without compromising locomotor activity or motor coordination in animals. It demonstrated promising energy values for potential pharmacological targets, indicating its potential as a drug candidate.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Review
Biotechnology & Applied Microbiology
Thaissa Q. Machado, Anna C. C. da Fonseca, Allana B. S. Duarte, Bruno K. Robbs, Damiao P. de Sousa
Summary: This review discusses the antitumor activity of monoterpenes found in essential oils and their pharmacological mechanisms. Carvacrol and linalool are the most investigated monoterpenes, showing significant antitumor effects in various types of cancers. These natural products inhibit tumor growth through multiple mechanisms, including apoptosis, cell cycle impairment, ROS production, and autophagy. The findings from this study are important for advancing the understanding of the mechanisms of monoterpenes and developing synthetic drugs with better anticancer effects.
BIOMED RESEARCH INTERNATIONAL
(2022)
Review
Chemistry, Medicinal
Luxuan Zhang, Hua Yu, Haifang Chen, Yinghong Huang, Irina Bakunina, Damia Pregentino de Sousa, Mingna Sun, Jianye Zhang
Summary: The molecular imprinting technique is an attractive and prominent method for synthesizing materials used for target recognition and rapid separation. It has been successfully applied in the separation of active compounds from various plants, such as flavonoids, organic acids, alkaloids, phenylpropanoids, anthraquinones, phenolics, terpenes, steroids, and diketones. This review provides a brief introduction of molecularly imprinted polymers and their efficient application in the separation of active components from plants, offering valuable insights for stimulating further research in this fascinating and useful field.
Article
Chemistry, Physical
Francisco Valmor Macedo Cunha, Arthur Sergio Avelino de Medeiros, Alaine Maria dos Santos Silva, Mayara Castro de Morais, Damiao Pergentino de Sousa, Francisco de Assis Oliveira, Arnobio Antonio da Silva Jr, Livio Cesar Cunha Nunes
Summary: Different nanoemulsion (NE) formulations were prepared to achieve a stable and efficient aqueous colloidal dispersion of ethyl ferulate (EF), which is immiscible with water. The NE samples, selected from a pseudo-ternary phase diagram, exhibited physical stability and controlled drug release. In vivo experiments with rats showed the biocompatibility and anti-inflammatory effect of the EF nanoemulsion. This study suggests the potential of EF nanoemulsion as a novel drug delivery system for topical anti-inflammatory application.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Pharmacology & Pharmacy
Danielly Silva de Melo, Jose Arimatea de Oliveira Nery Neto, Maisa de Sousa dos Santos, Vinicius Duarte Pimentel, Rita de Cassia Viana Carvalho, Valeria Carlos de Sousa, Ruy Gabriel Costa Sousa, Lazaro Gomes do Nascimento, Michel Mualem de Moraes Alves, Daniel Dias Rufino Arcanjo, Damiao Pergentino de Sousa, Fernando Aecio de Amorim Carvalho
Summary: Isopropyl gallate (IPG) showed affinity for enzymes pteridine reductase (PTR1) and oligopeptidase B (OPB) and demonstrated antileishmanial activity and low cytotoxicity in macrophages. IPG also exhibited good lipophilicity, oral bioavailability, and skin permeability, as well as non-mutagenic, non-carcinogenic properties and low risk of cardiac toxicity. These findings suggest that IPG has potential as a selective and effective treatment for leishmaniasis.
Article
Biochemistry & Molecular Biology
Rayanne H. N. Silva, Thaissa Q. Machado, Anna Carolina C. da Fonseca, Eduardo Tejera, Yunierkis Perez-Castillo, Bruno K. Robbs, Damiao P. de Sousa
Summary: Cancer is a major cause of death worldwide and effective pharmacological treatment to improve quality of life and reduce mortality remains a challenge. Piplartine, an alkamide found in certain species of the Piper genus, has shown antitumor activity. In this study, the cytotoxic potential of a collection of piplartine analogs against human oral SCC9 carcinoma cells was evaluated.
Article
Biochemistry & Molecular Biology
Mayara Castro de Morais, Edeltrudes de Oliveira Lima, Yunierkis Perez-Castillo, Damiao Pergentino de Sousa
Summary: In this study, nineteen synthetic cinnamides and cinnamates were prepared and evaluated for their antimicrobial activity against pathogenic fungi and bacteria. Derivative 6 showed the best antifungal profile, while derivative 18 exhibited the best antibacterial profile. These compounds could serve as prototypes for the development of new antimicrobial drugs.
Article
Biochemistry & Molecular Biology
Carlos S. M. B. Filho, Ramon R. P. P. B. de Menezes, Emanuel P. Magalhaes, Yunierkis P. Castillo, Alice M. C. Martins, Damiao P. de Sousa
Summary: This study evaluated the trypanocidal activity of 13 ester compounds analogous to Piplartine and found that compound 11 showed good activity against Trypanosoma cruzi through the induction of oxidative stress and mitochondrial damage. The study suggests that compound 11 has potential for the development of new trypanocidal prototypes for researching drugs against Chagas disease.
Review
Biochemistry & Molecular Biology
Lucio Ricardo Leite Diniz, Leonardo Luiz Calado, Allana Brunna Sucupira Duarte, Damiao Pergentino de Sousa
Summary: Studies have shown that Centella asiatica extracts (CAE) display activity in tissue regeneration, cell migration, and wound repair process. Its active component, asiatic acid, is directly associated with its healing activity. This study discusses the effects of Centella asiatica and asiatic acid in different stages of the healing process of cutaneous wounds, including phytochemical and antimicrobial aspects.
Review
Biochemistry & Molecular Biology
Damiao P. de Sousa, Renan Oliveira S. Damasceno, Riccardo Amorati, Hatem A. Elshabrawy, Ricardo D. de Castro, Daniel P. Bezerra, Vitoria Regina V. Nunes, Rebeca C. Gomes, Tamires C. Lima
Summary: In this review, the authors provide an overview of the mechanisms of pharmacological action of essential oils and their components in various biological systems. They discuss the antioxidant, anti-inflammatory, antitumor, antimicrobial activities, as well as the mechanisms of action against various types of viruses. The data indicate that the chemical diversity in the composition of essential oils allows them to interfere with biological processes at different levels, making them a promising source for the development of new drugs.
Review
Chemistry, Medicinal
Allana Brunna S. Duarte, Rebeca C. Gomes, Vitoria Regina V. Nunes, Juan Carlos R. Goncalves, Camylla A. Correia, Ana Zulmira G. dos Santos, Damiao P. de Sousa
Summary: This review summarizes the research on the antitumor activity of piplartine, confirming its potential as an anticancer agent against various types of tumors. The evidence found in this study serves as a reference for advancing mechanistic research on this metabolite and developing new drug candidates.
Article
Tropical Medicine
Renan Braga, Humberto Andrade, Ryldene Cruz, Mayara Maia, Carolina Lima, Anderson Santos, Andre Miranda, Allana Duarte, Marcus Scotti, Reinaldo Almeida, Damiao Sousa
Summary: Perillyl acetate has antinociceptive activity in mice, possibly through mu-opioid receptors, without affecting motor coordination.
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
(2022)
