期刊
MOLECULES
卷 16, 期 5, 页码 4305-4317出版社
MDPI AG
DOI: 10.3390/molecules16054305
关键词
7-aminocoumarins; N-(coumarin-7-yl)hydrazonoyl chloride; 1-piperazinyl amidrazones; nitrileimine; antitumor activity
资金
- University of Jordan, Amman, Jordan
A series of new N1-(coumarin-7-yl)amidrazones incorporating N-piperazines and related congeners were synthesized by reacting the hydrazonoyl chloride derived from 7-amino-4-methylcoumarin with the appropriate piperazines. The chemical structures of the newly prepared compounds were supported by elemental analyses, (1)H-NMR, (13)C-NMR, and ESI-HRMS spectral data. The antitumor activity of the newly synthesized compounds was evaluated. Among all the compounds tested, 7-{2-[1-(4-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl)piperazin-1-yl)-2-oxopropylidene]hydrazinyl}-4-methyl-2H-chromen-2-one (3n) was the most potent against MCF-7 and K562 cells, with IC(50) values of 20.2 and 9.3 mu M, respectively.
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