期刊
MOLECULES
卷 16, 期 3, 页码 2075-2083出版社
MDPI
DOI: 10.3390/molecules16032075
关键词
cyanidin-3-rutinoside; pancreatic alpha-amylase; acarbose; additive inhibition
资金
- Government Research Budget, Thailand
- Chulalongkorn University
The inhibitory activity on pancreatic alpha-amylase by cyanidin-3-rutinoside was examined in vitro. The IC50 value of cyanidin-3-rutinoside against pancreatic alpha-amylase was 24.4 +/- 0.1 mu M. The kinetic analysis revealed that pancreatic mu-amylase was inhibited by cyanidin-3-rutinoside in a non-competitive manner. The additive inhibition of a combination of cyanidin-3-rutinoside with acarbose against pancreatic alpha-amylase was also found. These results provide the first evidence for the effect of cyanidin-3-rutinoside in a retarded absorption of carbohydrates by inhibition of pancreatic alpha-amylase which may be useful as a potential inhibitor for prevention and treatment of diabetes mellitus.
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