Article
Biology
Marija Vukomanovic, Lea Gazvoda, Mario Kurtjak, Jitka Hrescak, Blaz Jaklic, Laura Moya-Anderico, Maria del Mar Cendra, Eduard Torrents
Summary: Designing useful functionalities in clinically validated, old antibiotics holds promise to provide an economical solution for the global lack of effective antibiotics. The use of cyclodextrin and arginine as linkers creates a more stable ternary antibiotic complex, improving antimicrobial efficacy and safety.
COMMUNICATIONS BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Tatyana V. Volkova, Olga R. Simonova, German L. Perlovich
Summary: This study investigated the complex formation of antiandrogen bicalutamide (BCL) with methylated and acetylated beta-cyclodextrins, and its effect on dissolution/permeation processes. The results revealed a higher binding affinity of BCL to acetylated beta-cyclodextrin compared to methylated beta-cyclodextrin. The solid dispersion of BCL with acetylated beta-cyclodextrin showed improved dissolution and supersaturation compared to the raw drug and physical mixture. The presence of polymers (PVP and HPMC) prolonged the supersaturation state and enhanced dissolution and permeation processes.
Article
Polymer Science
Mohamed Gamal Mohamed, Tso Shiuan Meng, Shiao Wei Kuo
Summary: A new water-soluble benzoxazine-functionalized cyclodextrin monomer was synthesized and confirmed to improve thermal stability and water-solubility when incorporating cyclodextrin into the benzoxazine monomer. Furthermore, investigation on the beta-CD-BZ/PPG inclusion complex showed that the benzoxazine units could provide thermal curing polymerization behavior to enhance their thermal properties.
Article
Polymer Science
Muhammad Suhail, Quoc Lam Vu, Pao-Chu Wu
Summary: In this study, pH-responsive polymeric hydrogels were successfully fabricated using the free radical polymerization technique. The properties of the hydrogels were evaluated using various analytical techniques. The results demonstrated that the hydrogels exhibited high thermal stability and pH sensitivity, making them suitable for the controlled release of theophylline.
Article
Biochemistry & Molecular Biology
Magdalena Paczkowska-Walendowska, Natalia Rosiak, Ewa Tykarska, Katarzyna Michalska, Anita Plazinska, Wojciech Plazinski, Daria Szymanowska, Judyta Cielecka-Piontek
Summary: The study successfully altered the dissolution rate and permeability of tedizolid by forming solid dispersions with cyclodextrin, while maintaining high microbiological activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yixing Lu, Liuye Yang, Wanying Zhang, Shiting Xie, Feifei Zhao, Xianfeng Peng, Zonghua Qin, Dongping Zeng, Zhenling Zeng
Summary: In this study, we prepared an IBG/HP-beta-CD complex and found that it significantly improved the aqueous solubility, pharmaceutical properties, absorption, and bioavailability of IBG.
Article
Chemistry, Multidisciplinary
Aamir Aman, Saba Ali, Panupong Mahalapbutr, Kuakarun Krusong, Peter Wolschann, Thanyada Rungrotmongkol
Summary: Sorafenib (SOR) is an effective oral multikinase inhibitor for inhibiting cancer cell growth and spread. However, its tablets have limited oral bioavailability due to low water solubility. This study explores the use of cyclodextrins (CDs) as molecular encapsulating agents to improve the solubility and stability of SOR. Among the investigated CDs, SBEbCD showed the highest binding affinity with SOR and demonstrated improved solubility and stability.
Article
Chemistry, Multidisciplinary
Muhammad Inam, Chi Uyen Phan, Jian-Wei Wang, Muhammad Jamshed, Xiurong Hu, Guping Tang
Summary: Drug solubility is important for drug formulation development. This study aims to improve the solubility of vortioxetine (VT) by preparing inclusion complexes (ICs) with beta-Cyclodextrin (beta-CD) and gamma-Cyclodextrin (gamma-CD). The ICs were characterized using various analytical techniques and their solubility and dissolution rate were compared to the pristine VT drug. The results showed that the ICs had higher solubility and faster dissolution rate in various media.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Deepank S. Gupta, Pankul Kotwal, Utpal Nandi, Sonali S. Bharate
Summary: This study explores the potential of beta-cyclodextrin and its derivatives for enhancing the dissolution of niclosamide. Among the cyclodextrins studied, 2-Hydroxypropyl-beta-cyclodextrin in the 1:2 molar ratio shows the most significant improvement in water solubility and in-vitro dissolution of niclosamide. Oral administration of the niclosamide and HP-beta-CD complex in rats resulted in higher plasma exposure. Spectral characterization provides insights into the interactions between niclosamide and HP-beta-CD.
Article
Pharmacology & Pharmacy
Qiuhua Luo, Qianying Zhang, Puxiu Wang
Summary: Hydrochlorothiazide/losartan potassium was used to prepare compound tablets. The formulation and preparation factors were determined based on the investigation of compression and mechanical properties of the mixed powders. The optimal formulation was selected using D-optimal mixture experimental design. The bioavailability of the No.1 tablet was found to be comparable to the Hyzaar tablet in beagle dogs.
Review
Chemistry, Multidisciplinary
Xin-Kun Ma, Yu Liu
Summary: Organic room-temperature phosphorescence (RTP) has attracted attention in recent years, leading to the development of supramolecular phosphorescence. By utilizing the synergy between supramolecular co-assembly and strong binding by macrocyclic host compounds, deficiencies in RTP materials can be overcome, improving efficiency and expanding applications in aqueous solutions and cell imaging. This approach shows promising prospects in chemistry, biology, and material science.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Spectroscopy
Arti Yadav, Rajni Chaudhary, Ashok Singh Bahota, Preeti Prajapati, Jaya Pandey, Aditya Narayan, Poonam Tandon, Venu R. Vangala
Summary: This study investigates the structural, vibrational, and chemical properties of Hydrochlorothiazide (HCTZ) using computational methods and experimental techniques. The formation of hydrogen bonds and the chemical reactivity of HCTZ were analyzed. The findings contribute to a better understanding of the pharmacological effects of HCTZ.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Multidisciplinary Sciences
Mokhtar Ganjali Koli, Rahime Eshaghi Malekshah, Hossein Hajiabadi
Summary: This study explores the interaction between benzodiazepine (BZD) drugs and 2-hydroxypropyl-beta-cyclodextrin (2HP beta CD), a cyclodextrin known for its drug delivery enhancement. The study reveals that the presence of certain BZDs affects the rigidity or flexibility of 2HP beta CD's atoms. The research also demonstrates that loading BZDs into 2HP beta CD increases its cavity area and volume, improving drug delivery capability.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Yining Zhu, Xinmu Li, Zhaoye Bai, Yujia Zeng, Han Jiang, Xiaoping Bai, Ruijun Li
Summary: Membrane separation technology is a highly promising method for chiral drug separation due to its high energy efficiency, continuous operation, and economic benefits. The use of mixed matrix membranes (GO/EDA-beta-CD MMMs) incorporating graphene oxide (GO) and mono(6-ethylenediamine-6-deoxy)-beta-cyclodextrin (EDA-beta-CD) as modifiers showed enhanced permeability and selectivity. The GO/EDA-beta-CD MMMs demonstrated higher enantioseparation performance for chiral drugs compared to EDA-beta-CD MMMs, indicating their potential for industrial chiral drug separation.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Engineering, Chemical
Yaewon Park, Debjyoti Banerjee, Soo Ah Jin, Shanshan Li, Susan Beck, Lauren Purser, Ericka Ford
Summary: In this research, the inclusion complex (IC) formation of a representative organophosphate flame retardant (FR), 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO), with γ-cyclodextrins (γ-CD) was studied to enhance char formation and prevent the release of toxic FR chemicals. The addition of ionic salts increased the yield of IC crystals. However, perfect crystals were formed only when pure IC was formed. The formed IC was found to be compatible with biopolymer CAB and showed better flame response compared to reference fibers.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Chemistry, Physical
Jesus Nuncira, Luciana Moreira Seara, Ruben Dario Sinisterra, Vinicius Caliman, Glaura Goulart Silva
FULLERENES NANOTUBES AND CARBON NANOSTRUCTURES
(2020)
Article
Cell Biology
Itamar Couto Guedes Jesus, Thassio Ricardo Ribeiro Mesquita, Andre Luis Lima Monteiro, Amanda Borges Parreira, Anderson Kenedy Santos, Elizeu Lucas Xavier Coelho, Mario Morais Silva, Lucas A. C. Souza, Maria Jose Campagnole-Santos, Robson Souza Santos, Silvia Guatimosim
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2020)
Article
Immunology
Aline Candida Bastos, Giselle Santos Magalhaes, Juliana Fabiana Gregorio, Natalia Alves Matos, Daisy Motta-Santos, Frank Silva Bezerra, Robson Augusto Souza Santos, Maria Jose Campagnole Santos, Maria Gloria Rodrigues-Machado
Article
Immunology
Giselle Santos Magalhaes, Juliana Fabiana Gregorio, Kezia Emanoeli Ramos, Arthur Tonani Pereira Cancado-Ribeiro, Isis Felippe Baroni, Luciola Silva Barcelos, Vanessa Pinho, Mauro Martins Teixeira, Robson Augusto Souza Santos, Maria Gloria Rodrigues-Machado, Maria Jose Campagnole-Santos
Article
Biochemistry & Molecular Biology
Gabriela Cavazza Cerri, Daisy Motta-Santos, Joao Marcus Oliveira Andrade, Luiz Fernando de Rezende, Robson Augusto Souza dos Santos, Sergio Henrique Sousa Santos
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2020)
Article
Endocrinology & Metabolism
Luis Paulo Oliveira, Victor Hugo Dantas Guimaraes, Janaina Ribeiro Oliveira, Andre Luiz Sena Guimaraes, Alfredo Mauricio Batista de Paula, Michael Bader, Robson Augusto Souza dos Santos, Sergio Henrique Sousa Santos
Article
Biochemical Research Methods
Diana P. Gomez-Mendoza, Rafael Pereira Lemos, Itamar C. G. Jesus, Vladimir Gorshkov, Shaun M. K. McKinnie, John C. Vederas, Frank Kjeldsen, Silvia Guatimosim, Robson Augusto Santos, Adriano M. C. Pimenta, Thiago Verano-Braga
JOURNAL OF PROTEOME RESEARCH
(2020)
Letter
Endocrinology & Metabolism
Daisy Motta-Santos, Robson A. S. Santos, Sergio Henrique Sousa Santos
Article
Cell Biology
Michaela Andrae, Miriam Russ, Susanne Jauk, Mariana Lamacie, Ingrid Lang, Robert Arnold, Iva Brcic, Robson Santos, Reinhold Wintersteiger, Astrid Ortner
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Editorial Material
Physiology
Giselle Santos Magalhaes, Maria da Gloria Rodrigues-Machado, Daisy Motta-Santos, Maria Jose Campagnole-Santos, Robson A. Souza Santos
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Cell Biology
Nathalia Senger, Aline C. Parletta, Bruno V. D. Marques, Eliana H. Akamine, Gabriela P. Diniz, Maria J. Campagnole-Santos, Robson A. S. Santos, Maria Luiza M. Barreto-Chaves
Summary: Clinical studies have shown a correlation between thyroid disorders and cardiac diseases, with high levels of T3 inducing cardiac hypertrophy. Angiotensin-(1-7) treatment was found to block T3-induced cardiac hypertrophy by increasing nuclear FOXO3 levels and reducing p-FOXO3 levels. This new molecular mechanism involves increased expression of antioxidant enzymes and reduced levels of reactive oxygen species and NF-kappa B, offering potential therapeutic targets.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Virginia M. Pereira, Fernando M. Reis, Geovanni D. Cassali, Sergio H. S. Santos, Maira Casalechi, Robson A. S. Santos, Adelina M. Reis
JOURNAL OF MOLECULAR HISTOLOGY
(2020)
Article
Pharmacology & Pharmacy
Maria Andrea Barbosa, Claudiane Maria Barbosa, Taynara Carolina Lima, Robson Augusto Souza dos Santos, Andreia Carvalho Alzamora
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Juan Carlos Rivera, Johanna Abrigo, Franco Tacchi, Felipe Simon, Enrique Brandan, Robson A. Santos, Michael Bader, Mario Chiong, Claudio Cabello-Verrugio
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Infectious Diseases
Mariana Paiva Rodrigues, Priscila Natalia Pinto, Raul Roque de Souza Dias, Gabriela Lago Biscoto, Lauranne Alves Salvato, Ruben Dario Sinisterra Millan, Ricardo Mathias Orlando, Kelly Moura Keller
Summary: Nanoparticles (NPs) have unique characteristics that make them interesting for biological and medical applications. Researchers are studying the potential use of nanoparticles in veterinary medicine, such as drug delivery systems. NPs have shown antibacterial, antifungal, and antiviral activity, making them useful in preventing and treating animal diseases. This review aims to explore the clinical and preventive veterinary applications of inorganic and organic nanoparticles.
