期刊
MOLECULES
卷 16, 期 12, 页码 10214-10226出版社
MDPI
DOI: 10.3390/molecules161210214
关键词
Cordia sinensis; antioxidant; anti-inflammatory; anti-glycation
资金
- Research Centre of the Centre for Female Scientific and Medical Colleges in the King Saud University
Nine compounds have been isolated from the ethyl acetate soluble fraction of C. sinensis, namely protocatechuic acid (1), trans-caffeic acid (2), methyl rosmarinate (3), rosmarinic acid (4), kaempferide-3-O-beta-D-glucopyranoside (5), kaempferol-3-O-beta-D-glucopyranoside (6), quercetin-3-O-beta-D-glucopyranoside (7), kaempferide-3-O-alpha-L-rhamnopyranosyl (1 -> 6)-beta-D-glucopyranoside (8) and kaempferol-3-O-alpha-L-rhamnopyranosyl (1 -> 6)-beta-D-glucopyranoside (9), all reported for the first time from this species. The structures of these compounds were deduced on the basis of spectroscopic studies, including 1D and 2D NMR techniques. Compounds 1-9 were investigated for biological activity and showed significant anti-inflammatory activity in the carrageen induced rat paw edema test. The antioxidant activities of isolated compounds 1-9 were evaluated by the DPPH radical scavenging test, and compounds 1, 2, 4 and 7-9 exhibited marked scavenging activity compared to the standard BHA. These compounds were further studied for their anti-glycation properties and some compounds showed significant anti-glycation inhibitory activity. The purity of compounds 2-5, 8 and 9 was confirmed by HPLC. The implications of these results for the chemotaxonomic studies of the genus Cordia have also been discussed.
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