期刊
MOLECULES
卷 15, 期 2, 页码 871-877出版社
MDPI
DOI: 10.3390/molecules15020871
关键词
marine sponge; Callyspongia sp.; diazepine; callysponine
资金
- National Natural Science Foundation of China [40706046, 30973679, 20902094]
- Knowledge Innovation Program of Chinese Academy of Sciences [LYQY 200703, SQ200904]
- National Key Basic Research Program of China (973)'s Project [2010CB833800]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
- LMB Foundation [091002]
A new 1,4-diazepine, callysponine (1), was isolated from a South China Sea Callyspongia sp. marine sponge, together with four known proline-based diketopiperazines: cyclo-(S-Pro-R-Leu) (2), cyclo-(S-Pro-R-Val) (3), cyclo-(S-Pro-R-Ala) (4), and cyclo-(S-Pro-R-Tyr) (5). The new structure was determined on the basis of NMR and MS analysis, and the absolute stereochemistry was defined by NOESY spectroscopy and optical rotation. The structures of the known compounds were identified by comparison of their spectroscopic data with those reported in the literature. Callysponine (1) did not inhibit the growth of HepG2 (hepatoma carcinoma cell), A549 (lung carcinoma cell), and HeLa (cervical cancer cell) cell lines.
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