期刊
MOLECULES
卷 14, 期 9, 页码 3286-3312出版社
MDPI
DOI: 10.3390/molecules14093286
关键词
squalene; squalane; adjuvant; emulsion; parenteral
资金
- Bill & Melinda Gates Foundation [42387]
Squalene is a linear triterpene that is extensively utilized as a principal component of parenteral emulsions for drug and vaccine delivery. In this review, the chemical structure and sources of squalene are presented. Moreover, the physicochemical and biological properties of squalene-containing emulsions are evaluated in the context of parenteral formulations. Historical and current parenteral emulsion products containing squalene or squalane are discussed. The safety of squalene-based products is also addressed. Finally, analytical techniques for characterization of squalene emulsions are examined.
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