Article
Infectious Diseases
John Awungnjia Asong, Ebenezer Kwabena Frimpong, Hlabana Alfred Seepe, Lebogang Katata-Seru, Stephen Oluwaseun Amoo, Adeyemi Oladapo Aremu
Summary: This study focused on the green synthesis of silver nanoparticles (CTAgNP) using Cullen tomentosum (Thunb.) J.W. Grimes acetone extract and evaluated the antibacterial activity of the plant extract and biogenic nanoparticles against two Gram-positive bacteria strains. The results showed that the plant extract and CTAgNP exhibited moderate antibacterial effects. The CTAgNP was found to have a face-centered cubic structure and a protective shell layer composed of organic compounds from the plant extract.
Article
Chemistry, Multidisciplinary
D. Ashok, Katta Ramakrishna, Nalaparaju Nagaraju, M. Ram Reddy, Ravinder Dharavath, M. Sarasija
Summary: A number of new imidazole-coumarin structures have been synthesized and characterized, showing antimicrobial activity against a variety of bacteria and fungi.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Li-Xia Zhao, Zhi-Xin Wang, Yue-Li Zou, Shuang Gao, Ying Fu, Fei Ye
Summary: By synthesizing a series of novel phenoxypyridine derivatives, compounds W3.1 and W3.4 were found to exhibit excellent herbicidal activity, similar to the commercial herbicide oxyfluorfen. Among these compounds, W3.4 showed the best herbicidal activity and deserves further research for new herbicide development.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Alexandra Quek, Hafizah Mohd Zaini, Nur Kartinee Kassim, Fadzil Sulaiman, Yaya Rukayadi, Amin Ismail, Zamirah Zainal Abidin, Khalijah Awang
Summary: Melicope glabra is a rich source of plant secondary metabolites, with compounds such as umbelliferone and sesamin showing promising antibacterial activity. The study demonstrates the potential of M. glabra as a natural source of potent antioxidants and antibacterial agents.
Article
Chemistry, Physical
Nada Abdulwali, Joshua van der Zalm, Antony R. Thiruppathi, Aiman Khaleel, Aicheng Chen
Summary: Well-dispersed mono-carbon microspheres with uniform morphology and abundant oxygen functional groups were synthesized via hydrothermal carbonization of ascorbic acid. The size of the carbon spheres could be easily controlled by adjusting the reaction conditions. The synthesized carbon spheres exhibited high antibacterial activity against E. coli and S. aureus, making them promising for various applications in surface coating, medical, and environmental fields.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Multidisciplinary
Samar A. Abubshait, Haya A. Abubshait, Rasha Almalih, Mohamed S. Gomaa, Muhammad Nawaz, Ibtisam M. Ababutain, Azzah I. Alghamdi
Summary: The synthesis and characterization of phthalazinone derivatives using a green synthesis protocol is reported. These derivatives exhibit effective antimicrobial and anticancer activities, with the most potent derivative showing high anticancer activity potentially through inhibition of PARP. Molecular docking studies support the antiproliferative activity of these derivatives.
Article
Biochemistry & Molecular Biology
Lukasz Palkowski, Maciej Karolak, Jerzy Blaszczynski, Jerzy Krysinski, Roman Slowinski
Summary: This paper presents the results of SAR studies on 140 compounds using DRSA approach, revealing the relationships between compound structure and surface properties with antibacterial activity. Decision rules indicate directions for synthesizing more effective antibacterial compounds. Analysis also showed differences in parameter application for Gram-positive and Gram-negative strains.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Rakesh V. Kusurkar, Rahul H. Rayani, Deepa R. Parmar, Divyang R. Patel, Mrugesh J. Patel, Nilesh O. Pandey, Vishwanath Zunjar, Jigar Y. Soni
Summary: In this study, new phenyl substituted 3-chloro 2-azetidinone derivatives were successfully synthesized using a microwave-assisted synthesis method. The synthesized compounds exhibited promising antimicrobial activity, with compound 8c showing the strongest antibacterial and antifungal effects against Escherichia coli and Aspergillus niger.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Sefa Celik, Ali Tugrul Albayrak, Sevim Akyuz, Aysen E. Ozel, Belgi Diren Sigirci
Summary: Density functional theory calculations were used to predict the molecular geometry and electrostatic potential of the synthesized compound CL-Gly, along with molecular docking study to understand its interaction with DNA. Antibacterial activities against both Gram-positive and Gram-negative bacteria were determined, and in silico ADMET study showed good drug-like behavior and non-toxic nature of the compound, suggesting its importance in drug discovery.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Biochemistry & Molecular Biology
Nisha Kamra, Suman Rani, Sumit Thakral, Ajeet Singh, Payare L. Sangwan, Shashank K. Singh, Samridhi Thakral, Vikramjeet Singh, Devinder Kumar
Summary: In this study, a series of novel heterocyclic chalcones were synthesized and screened for their cytotoxic and antimicrobial activity. Some of the heterocyclic chalcones showed good cytotoxicity and antimicrobial activity. Molecular docking results revealed multiple interactions between the synthesized heterocyclic chalcones and their respective biochemical targets.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Chemistry, Physical
Meryem Erol, Ismail Celik, Gulcan Kuyucuklu
Summary: In this study, new benzoxazole derivatives were synthesized and their antimicrobial activities were investigated against various bacteria and fungi. Molecular docking and dynamics simulations showed that some compounds interacted well with the DNA gyrase enzyme. Additionally, the predicted ADME profiles of the compounds were in line with important drug design rules.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Biochemistry & Molecular Biology
Alka Pawar, Chandrika Konwar, Prakash Jha, Ravi Kant, Madhu Chopra, Uma Chaudhry, Daman Saluja
Summary: Neisseria gonorrhoeae (NG) is classified as a 'Priority' two organism by the World Health Organization due to its increased resistance to antibiotics. This study identified esculetin as a potential lead compound for developing new drugs against multidrug-resistant strains of NG. Esculetin inhibited the growth of NG, caused cell wall damage, and inhibited the activity of an enzyme involved in peptidoglycan biosynthesis. These findings highlight the importance of exploring phytochemicals for the treatment of antibiotic-resistant infections.
MOLECULAR DIVERSITY
(2023)
Article
Chemistry, Physical
Laila H. Abdel-Rahman, Maram T. Basha, Badriah Saad Al-Farhan, Mohamed Ismael
Summary: The study revealed that the newly synthesized copper(II) ternary complexes showed strong antimicrobial activity against different bacteria and fungi, suggesting their potential as alternatives to antibiotics.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Eman Sabry, Hanan A. Mohamed, Ewies F. Ewies, Benson M. Kariuki, Osama M. Darwesh, Mohamed S. Bekheit
Summary: A series of novel alpha-aminophosphonates bearing the sulfisoxazole moiety were synthesized, with compounds 3j, 3l and 3m exhibiting potent antimicrobial activities against five pathogenic microorganisms. Compound 3m showed the most promising antibacterial activity among all the synthesized derivatives, with potent and broad-spectrum effects against bacterial species tested.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Weerachai Phutdhawong, Apiwat Chuenchid, Thongchai Taechowisan, Jitnapa Sirirak, Waya S. Phutdhawong
Summary: A series of novel coumarin-3-carboxamide derivatives were designed and synthesized, showing little to no activity against gram-positive and gram-negative bacteria but potential to inhibit cancer cell growth. Among them, 4-fluoro and 2,5-difluoro benzamide derivatives exhibited the most potent activity against cancer cell lines, with low cytotoxicity against normal cell lines. The molecular docking study revealed the importance of benzamide functionality for anticancer activity by binding to the active site of the CK2 enzyme.
Article
Biology
Jovana V. Jovankic, Danijela M. Cvetkovic, Milena G. Milutinovic, Danijela D. Nikodijevic, Aleksandra G. Nikezic, Filip J. Grbovic, Nenad L. Vukovic, Milena D. Vukic, Dragana Z. Jakovljevic, Snezana D. Markovic
Summary: This study aims to evaluate the anticancer properties and impact on fatty acid synthesis process of Ocimum minimum L. flowers in triple-negative breast cancer cell lines and normal cells. The results showed that bioactive compounds from Ocimum minimum L. exhibited cytotoxic, proapoptotic, and prooxidant effects on breast cancer cells and suppressed genes and protein involved in fatty acid synthesis.
Article
Plant Sciences
Miroslava Kacaniova, Lucia Galovicova, Petra Borotova, Nenad L. Vukovic, Milena Vukic, Simona Kunova, Pavel Hanus, Ladislav Bakay, Edyta Zagrobelna, Maciej Kluz, Przemyslaw Lukasz Kowalczewski
Summary: This study reports on the chemical composition, antioxidant, antimicrobial and anti-insect activity of Ocimum basilicum essential oil (OBEO) obtained by steam distillation. OBEO showed strong antioxidant effects, inhibition of microbial growth, and insecticidal activity, making it a potential candidate for preserving fruit and vegetables.
Article
Biochemistry & Molecular Biology
Sandra S. Jovicic Milic, Verica V. Jevtic, Snezana R. Radisavljevic, Biljana V. Petrovic, Ivana D. Radojevic, Ivana R. Rakovic, Dorge S. Petrovic, Danijela Lj. Stojkovic, Milena Jurisevic, Nevena Gajovic, Angela Petrovic, Nebojsa Arsenijevic, Ivan Jovanovic, Olivera R. Klisuric, Nenad L. Vukovic, Milena Vukic, Miroslava Kacaniova
Summary: Newly synthesized palladium(II) complexes with derivatives of 2-aminothiazoles were characterized and their substitution reactions kinetics, as well as their interactions with DNA and BSA, were studied. The complexes exhibited cytotoxic activity and moderate antimicrobial activity.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Plant Sciences
Petra Borotova, Lucia Galovicova, Nenad L. Vukovic, Milena Vukic, Simona Kunova, Pawel Hanus, Przemyslaw Lukasz Kowalczewski, Ladislav Bakay, Miroslava Kacaniova
Summary: The essential oil from Litsea cubeba has strong antioxidant, antimicrobial, and anti-insect properties, making it a potential natural additive for food preservation. The main volatile organic compounds in the oil are geranial, neral, and limonene. It shows strong inhibition against bacteria and fungi.
Article
Plant Sciences
Milena D. Vukic, Nenad L. Vukovic, Milan Mladenovic, Nevena Tomasevic, Sanja Matic, Snezana Stanic, Filippo Sapienza, Rino Ragno, Mijat Bozovic, Miroslava Kacaniova
Summary: This study conducted a chemical composition analysis of different parts of Nepeta cataria and investigated their hepatoprotective and antigenotoxic features. The results showed that the extracts of Nepeta cataria exhibited significant pharmacological properties in protecting the liver of rats by modulating enzyme activities and redox status. Additionally, the extracts displayed antigenotoxic effects.
Article
Biochemistry & Molecular Biology
Milena D. Vukic, Ana D. Obradovic, Nenad L. Vukovic, Miroslava Kacaniova, Predrag M. Djurdjevic, Gorica T. Djelic, Milos M. Matic
Summary: This study compared the chemical composition of essential oils obtained from Orlaya grandiflora collected from two different locations and evaluated their potential in inhibiting colon and breast cancer cell lines. The results showed significant differences in the chemical compositions of the oils from the two locations. Both oils exhibited antitumor effects on the tested cells and could potentially be used in cancer treatment.
Article
Chemistry, Multidisciplinary
Veronika Valkova, Hana Duranova, Lucia Galovicova, Nenad L. Vukovic, Milena Vukic, Przemyslaw Lukasz Kowalczewski, Miroslava Kacaniova
Summary: This research investigated the chemical profile, antioxidant, and antifungal activities of three types of cinnamon essential oils. The results revealed that one of the C. verum EO exhibited the strongest antioxidant activity, and all analyzed essential oils demonstrated strong antifungal activities. The findings suggest the potential use of these essential oils for extending the shelf-life of bakery products.
APPLIED SCIENCES-BASEL
(2022)
Article
Agriculture, Dairy & Animal Science
Simona Kunova, Esther Sendra, Peter Hascik, Nenad L. Vukovic, Milena D. Vukic, Anis Ben Hsouna, Wissem Mnif, Miroslava Kacaniova
Summary: This study aimed to evaluate the microbiological quality of deer meat treated with Litsea cubeba essential oil (dissolved in rapeseed oil at concentrations of 0.5% and 1%) and vacuum packaging. The results showed that no coliform bacteria were detected in the samples treated with 1% Litsea cubeba essential oil throughout the storage period. The most frequently isolated bacteria from deer meat were Pseudomonas ludensis, Pseudomonas corrugata, Pseudomonas fragi, Bacillus cereus, Staphylococcus epidermidis, and Sphingomonas leidyi.
Article
Virology
Sanja Matic, Dragan Milovanovic, Zeljko Mijailovic, Predrag Djurdjevic, Predrag Sazdanovic, Srdjan Stefanovic, Danijela Todorovic, Suzana Popovic, Katarina Vitosevic, Vladimir Vukicevic, Milena Vukic, Nenad Vukovic, Nevena Milivojevic, Marko Zivanovic, Vladimir Jakovljevic, Nenad Filipovic, Dejan Baskic, Natasa Djordjevic
Summary: This study investigated the association of IFNL3 and IFNL4 polymorphisms with COVID-19 mortality, and found that increased CCI, N/L, and LDH level were associated with a lethal outcome. Additionally, females and patients with at least one variant allele of IFNL3 rs8099917 were almost 36 times more likely to survive SARS-CoV-2 infection, while the presence of at least one ancestral allele of IFNL4 rs368234815 decreased the likelihood of mortality from COVID-19 by more than 15-fold.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Miroslava Kacaniova, Nenad L. Vukovic, Natalia Cmikova, Lucia Galovicova, Marianna Schwarzova, Veronika Simora, Przemyslaw Lukasz Kowalczewski, Maciej Ireneusz Kluz, Czeslaw Puchalski, Ladislav Bakay, Milena D. Vukic
Summary: This study analyzed the chemical composition and various properties of Salvia sclarea essential oil (SSEO). The results showed that SSEO has moderate antimicrobial and antibiofilm activities, as well as insecticidal potential. The study also identified the main constituents of SSEO and their antioxidant activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Natalia Cmikova, Lucia Galovicova, Marianna Schwarzova, Milena D. Vukic, Nenad L. Vukovic, Przemyslaw Lukasz Kowalczewski, Ladislav Bakay, Maciej Ireneusz Kluz, Czeslaw Puchalski, Miroslava Kacaniova
Summary: This study analyzed the chemical composition and various biological activities of Eucalyptus globulus essential oil (EGEO). The main components of EGEO were identified as 1,8-cineole, p-cimene, α-pinene, and α-limonene. The results showed that EGEO exhibited significant antimicrobial, antibiofilm, antioxidant, and insecticidal activities.
Article
Plant Sciences
Lucia Galovicova, Natalia Cmikova, Marianna Schwarzova, Milena D. Vukic, Nenad L. Vukovic, Przemyslaw Lukasz Kowalczewski, Ladislav Bakay, Maciej Ireneusz Kluz, Czeslaw Puchalski, Ana D. Obradovic, Milos M. Matic, Miroslava Kacaniova
Summary: The aim of this study was to evaluate the various activities of the Cupressus sempervirens essential oil (CSEO), including antioxidant, antibiofilm, antimicrobial, insecticidal, and antiproliferative activities. The chemical composition of CSEO was determined, revealing the dominance of alpha-pinene and delta-3-carene. CSEO showed strong antioxidant activity, higher antibacterial efficacy, moderate antifungal activity, and demonstrated insecticidal effects. It also had no negative effects on normal cells but showed antiproliferative effects on certain cancer cells. Overall, CSEO has potential as an alternative treatment for various microorganisms and control of pests.
Article
Horticulture
Petra Borotova, Natalia Cmikova, Lucia Galovicova, Nenad L. Vukovic, Milena D. Vukic, Eva Tvrda, Przemyslaw Lukasz Kowalczewski, Maciej Ireneusz Kluz, Czeslaw Puchalski, Marianna Schwarzova, Ladislav Bakay, Miroslava Kacaniova
Summary: Frankincense, also known as Boswellia carterii, is a fragrant medicinal plant with potential applications in medicine and the food industry. The essential oil derived from this plant, composed mainly of alpha-pinene, alpha-limonene, and p-cymene, exhibits antimicrobial, anti-insect, and antioxidant activities. It shows strong antimicrobial activity against Candida species and inhibitory effects on bacterial growth on carrots. It also demonstrates high anti-insect activity against O. lavaterae. Evaluation of its effects on biofilm degradation revealed changes in the protein profile.
Article
Virology
Sanja Matic, Dragan Milovanovic, Zeljko Mijailovic, Predrag Djurdjevic, Predrag Sazdanovic, Srdjan Stefanovic, Danijela Todorovic, Suzana Popovic, Katarina Vitosevic, Vladimir Vukicevic, Milena Vukic, Nenad Vukovic, Nevena Milivojevic, Marko Zivanovic, Vladimir Jakovljevic, Nenad Filipovic, Natasa Djordjevic, Dejan Baskic
Summary: This study found that genetic polymorphisms in the IFNL4 gene may affect the risk of COVID-19 patients developing pneumonia, especially in females.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Horticulture
Lucia Galovicova, Natalia Cmikova, Nenad Vukovic, Milena Vukic, Przemyslaw Lukasz Kowalczewski, Ladislav Bakay, Miroslava Kacaniova
Summary: The essential oil of Jasminum grandiflorum has potent biological activity, including antioxidant and antimicrobial effects. It also demonstrates inhibitory effects on biofilm formation and insect pests.