☆ 4.6 Article

A structure-activity study of antibacterial diterpenoids

MOLECULES (2008)

期刊

MOLECULES

卷 13, 期 4, 页码 882-891

出版社

MDPI

DOI: 10.3390/molecules13040822

关键词

diterpenoids; antibacterial activity; structural requirements; phospholipid bilayer; docking

类别

Biochemistry & Molecular Biology Chemistry, Multidisciplinary

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Reagent

摘要

An analysis of the antibacterial activities of 15 terpenoids, eleven of which were previously described by us and four were extracted from the literature, suggested two structural requirements for activity of these and related compounds: a hydrophobic moiety, consisting of a substituted decalin skeleton, and a hydrophilic region possessing one hydrogen-bond-donor group. These structural requirements are responsible for an optimal insertion of these and related compounds into cell membranes, as suggested by the results of docking some of these compounds into a model phospholipid bilayer.

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