Article
Chemistry, Medicinal
Hai-Yan Zhao, Ya-Qi Wang, Yan-Cai Li, Qian Lan, Hai-Bing Liao, Heng-Shan Wang, Dong Liang
Summary: Multiple new flavonol glycosides and phenylpropanoid glycosides were isolated from Neoshirakia japonica, showing significant inhibitory effects against neuroinflammation. Compounds 1, 8, and 9 demonstrated stronger inhibitory activities compared to the positive control minocycline.
Article
Agriculture, Multidisciplinary
Qinggang Yin, Xiaoyan Han, Jingwang Chen, Zongxian Han, Liang Shen, Wei Sun, Shilin Chen
Summary: The study identified panasenoside and kaempferol 3-O-glucoside as commonly accumulated flavonol glycosides in ginseng leaves with cultivation years. A total of 50 UDP-glycosyltransferases (UGTs) were screened out to explore flavonol glycosylation in ginseng, with specific UGTs identified for the formation and modification of kaempferol 3-O-glucoside. The study highlights the significance of integrated metabolite profiles, proteomics, and phylogenetic analysis in understanding flavonol glycosylation pathways in ginseng.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Plant Sciences
Darren C. J. Wong, James Perkins, Rod Peakall
Summary: Sexually deceptive plants attract specific male insects for pollination by mimicking their characteristics. This study investigated the flower color biochemistry and gene expression patterns in different groups of the sexually deceptive orchid genus Chiloglottis using chemical and transcriptome analysis. The results showed that the dark calli/callus structures in these plants have conserved biochemical basis across the genus, but there are differences in the proportion of methoxylated anthocyanin and flavonol glycoside derivatives and gene expression levels between the Reflexa/Formicifera clades and the Valida clade.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Darren C. J. Wong, James Perkins, Rod Peakall
Summary: This study investigates the chemical composition and genetic regulation of flower color patterns in Chiloglottis trapeziformis, a sexually deceptive orchid. The researchers found that flower color in this orchid is achieved through complex tissue-specific coordinated regulation of genes and biochemical pathways across multiple developmental stages.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Haoliang Wan, Yihui Liu, Tongtong Wang, Peng Jiang, Weiwei Wen, Jiyun Nie
Summary: The downregulation of the transcription factor CsERF003 can increase the contents of major flavonoids and the precursor phenylalanine in the mutant orange and result in darker fruit color in tomato. CsERF003 may be a potentially promising gene for fruit quality improvement and engineering of natural flavonoid components.
Article
Chemistry, Applied
Yongxiang Wang, Xue Xie, Lina Liu, Hongda Zhang, Fuyong Ni, Jianhui Wen, Yun Wu, Zhenzhong Wang, Wei Xiao
Summary: Four new flavonol glycosides were isolated from Ginkgo biloba leaves, along with nine known flavonoids and two known lignans. Their structures were determined by spectroscopic analyses, and they showed stronger cardioprotective effects compared to acylated flavonol glycosides.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Qi Yan, Xu-hong Yong, Min Yin, Yu Shan, Shu Xu, Xiu-li Su, Xu Feng, Qi-zhi Wang
Summary: This study presents a phytochemical investigation on the dried and nearly ripe fruits of Evodia rutaecarpa (Juss.) Benth. and Evodia rutaecarpa (Juss.) Benth. var. bodinieri (Dode) Huang. A total of forty-five compounds were isolated, including twenty previously unreported compounds. This research may have chemotaxonomic significance within the genus.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tsukasa Iwashina, Masashi Nakata, Takahisa Nakane, Takayuki Mizuno
Summary: Twenty-one flavonoids were isolated and characterized from the leaves and stems of Hylotelephium sieboldii, a plant endemic to Japan. Kaempferol and quercetin glycosides were identified, including various types such as 3-O-sophorosides, 3-O-neohesperidosides, and 3-O-glucosides. The flavonoids differed between two varieties, with H. sieboldii var. sieboldii containing 3,7-O-glycosides and H. sieboldii var. ettyuense containing flavonol 3-O-diglycosides. Flavonoids were reported from Hylotelephium sieboldii for the first time in this study.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2022)
Article
Chemistry, Applied
Qingwen Sun, Guoji Pan, Wenfen Xu, Xian Lu, Caihong Bai, Mengge Liu, Yinrui Chen
Summary: A new flavonol glycoside, Sabiapside A, and four known compounds were isolated from Sabia parviflora, showing higher antioxidant activities compared to vitamin C. This finding is significant for studying the pharmacology and health benefits of natural products from plants.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Lei Wang, Tiantian Tang, Chenliang Zhao, Jianghai Ye, Kang He, Juan Zou
Summary: In this study, a new flavonol glycoside, as well as fourteen known compounds, were isolated from Pteris excelsa Gaud. The antioxidant activity of different fractions of the methanol extract of P. excelsa was determined, and compounds 1-6 showed antioxidant effect against the DPPH radical.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2023)
Article
Plant Sciences
Xing Jiang, Xi-Han Zhang, Yu-Xin Li, Kai Chen, Bin Lin, Tian-Qi Lu, Min Yang, Guang-Tong Chen, Bo-Yi Fan, Wen-Li Wang
Summary: A phytochemical investigation on the n-BuOH fraction of Cinnamomum camphora extract led to the discovery of 37 secondary metabolites, including a new phenylpropanoid glycoside compound. The isolated compounds showed potent inhibitory activities against alpha-glucosidase, indicating the potential beneficial effects of C. camphora leaves for the treatment of diabetes mellitus.
PHYTOCHEMISTRY LETTERS
(2023)
Article
Chemistry, Analytical
Sherouk Hussein Sweilam, Maha B. O. Ebrahim, Mehnaz Kamal, El-Sayed Khafagy, Ashraf N. Abdalla, Mohamed E. Elzubier, Ehssan H. Moglad
Summary: Combretaceae plants, especially Combretum glutinosum Perr. Ex Dc., have been traditionally used in Sudanese cultures for their medicinal properties. In this study, six compounds were isolated from the ethyl acetate extract of C. glutinosum, including a new flavonoid compound and five known compounds. These compounds showed cytotoxic activities against breast, colon, liver, and lung cancer cell lines, with compounds 1 and 6 exhibiting the highest cytotoxicity. Furthermore, compounds 1 and 3 demonstrated the ability to induce apoptosis and perturb the cell cycle in MCF7 cells.
Article
Plant Sciences
Jing Wen, Xin-Jia Yan, Cheng-Dong Nie, Qi-Xuan Wang, Wen-Lan Li
Summary: Two new flavonol glycosides were isolated from Selaginella tamariscina, but showed no cytotoxic activities against four different cell lines.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ilandarage Menu Neelaka Molagoda, Kyoung-Tae Lee, Athapaththu Mudiyanselage Gihan Kavinda Athapaththu, Yung-Hyun Choi, Jaeyoung Hwang, Su-Jin Sim, Sanghyuck Kang, Gi-Young Kim
Summary: The study demonstrated that JUB, EPA, and FRS isolated from Z. jujuba var. inermis (Bunge) Rehder seeds exhibit potent anti-melanogenic properties by inhibition of the cAMP-CERB-MITF axis and consequent tyrosinase activity. JUA and BTL were not effective in downregulating melanogenesis. Furthermore, JUB, EPA, and FRS directly inhibited in vitro mushroom tyrosinase enzyme activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Nguyen Thi Cuc, Duong Thi Dung, Ngo Anh Bang, Duong Thi Hai Yen, Nguyen Huy Hoang, Phan Van Kiem, Bui Huu Tai
Summary: Four new glycosides, named amplexicosides A-D, and five known compounds were isolated from the branches and leaves of Camellia amplexicaulis. Their structures were determined using spectroscopic and NMR techniques. Three compounds showed significant inhibition against alpha-glucosidase.
NATURAL PRODUCT RESEARCH
(2023)
Article
Computer Science, Software Engineering
Guo Zhou, Ruxin Zhao, Qifang Luo, Yongquan Zhou
Summary: This article introduces a new algorithm called quantum social spider optimization (QSSO), which improves the global search capability of the algorithm by introducing a bit encoding method. The QSSO algorithm is successfully applied to optimize hydropower station dispatch, and it has advantages such as fast convergence, high calculation accuracy, and good stability.
CONCURRENCY AND COMPUTATION-PRACTICE & EXPERIENCE
(2022)
Review
Food Science & Technology
Chunhua Zhang, Mingxi Li, Abdur Rauf, Anees Ahmed Khalil, Zhiguo Shan, Chuying Chen, Kannan R. R. Rengasamy, Chunpeng Wan
Summary: This review compiles the information on the potential use of alginate and alginate oligosaccharides (AOS) in different fields from 1994 to 2020. AOS, a degradation product of alginate, has gained attention for its beneficial properties in food, pharmaceutical, and agricultural industries. The review highlights the antimicrobial, antioxidant, anti-inflammatory, and other bioactive properties of AOS, and its applications in various sectors such as prebiotics, nutritional supplements, and plant growth development.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Plant Sciences
Nan Shan, Yupei Zhang, Yunhe Xu, Xin Yuan, Chunpeng Wan, Chuying Chen, Jinyin Chen, Zengyu Gan
Summary: In this study, the researchers isolated 12 KT/HAK/KUP genes from kiwifruit and analyzed their characteristics. They found that AcKUP2 may be an important potassium transporter gene involved in ethylene-regulated kiwifruit postharvest ripening.
Article
Cell Biology
Rui Zhang, Guo-Jun Geng, Jian-Guang Guo, Yan-Jun Mi, Xiao-Lei Zhu, Ning Li, Hong-Ming Liu, Jun-Feng Lin, Jian-Weng Wang, Guang Zhao, Guan-Zhi Ye, Bo-An Li, Qi-Cong Luo, Jie Jiang
Summary: This study identified a regulatory circuit linking NF-kappa B signaling and OVOL2 in the modulation of glucose metabolism in non-small cell lung cancer.
CELL COMMUNICATION AND SIGNALING
(2022)
Editorial Material
Nutrition & Dietetics
Chunpeng Wan, Kannan R. R. Rengasamy
FRONTIERS IN NUTRITION
(2022)
Article
Plant Sciences
Zihan Lin, Lijuan Liao, Shengchao Zhao, Wei Gu, Guanzhen Wang, Ziyi Shen, Yuanhui Wang, Kun Chen, Wei Liu, Yi Cai, Chunpeng Wan, Tingdong Yan
Summary: The study found that corylin is a substance that inhibits the progression of non-small cell lung cancer cells, and it inhibits the NF-kappa B signaling pathway by blocking p65 nuclear translocation. The study provides a novel strategy for improving the prognosis and treatment of non-small cell lung cancer patients.
Review
Food Science & Technology
Zaixiang Lou, Xiaodan Zheng, Dery Bede, Wenna Dai, Chunpeng Wan, Hongxin Wang, Xiaohua Chen
Summary: Biofilm is a stable microbial community with probiotic strains that have beneficial effects. This article introduces the formation process and regulatory mechanisms of biofilm, and reviews strategies to promote biofilm growth. The extraction and purification process of natural products in exogenous substances are summarized. Studies have found various ways to promote biofilm formation, such as interfering with quorum sensing pathways and adhesion mechanisms. Probiotics and their secondary metabolites, as well as certain ingredients like hormones and natural extracts, play critical roles in promoting biofilm formation.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Article
Food Science & Technology
Yupei Zhang, Duo Lin, Ruyu Yan, Yunhe Xu, Mengying Xing, Shuyuan Liao, Chunpeng Wan, Chuying Chen, Liqin Zhu, Wenbin Kai, Jinyin Chen, Zengyu Gan
Summary: This study investigated the effect of fucoidan treatment on cucumber under cold stress. The results showed that fucoidan treatment alleviated chilling injury, delayed weight loss, and lowered electrolyte leakage and respiration rate in cold-stored cucumbers. Fucoidan also maintained the integrity of cell membrane and reduced membrane lipid peroxidation.
Review
Neurosciences
Pooja Mittal, Rajat Goyal, Ramit Kapoor, Chunpeng Wan, Rupesh K. Gautam
Summary: Phytochemicals or natural products have been extensively studied for their potential in treating neurodegenerative diseases like Parkinson's disease and Alzheimer's disease. Despite having knowledge of the molecular pathways involved, little progress has been made in the treatment of these diseases. Natural products, however, have shown promise as neuroprotective agents and this review discusses their therapeutic potential.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Plant Sciences
Yi Cai, Shisheng Jiang, Chaoming Huang, Ao Shen, Xuan Zhang, Wanling Yang, Yichuan Xiao, Shuhan Gao, Rong Du, Guodong Zheng, Tingdong Yan, Chunpeng (Craig) Wan
Summary: In this study, baicalin was found to suppress cardiac hypertrophy through regulating the SIRT3/LKB1/AMPK signaling pathway. Additionally, baicalin upregulated SIRT3 protein expression by inhibiting proteasome and activating PSMB5. These results provide the first evidence that baicalin inhibits cardiac hypertrophy by targeting the SIRT3-dependent signaling pathway, suggesting its potential for the treatment of cardiac hypertrophy and heart failure.
Article
Agriculture, Dairy & Animal Science
Jianping Wang, Tao Zhang, Chunpeng Wan, Zhangfeng Lai, Jun Li, Luojun Chen, Mingxi Li
Summary: Pu-erh tea theabrownins (TBs) improve egg quality and antioxidant properties by modulating amino acid and fatty acid compositions, and activating the Nrf2-ARE signaling pathway.
Article
Food Science & Technology
Chunpeng (Craig) Wan, Xiaomeng Hu, Mingxi Li, Kannan R. R. Rengasamy, Yi Cai, Zhonghua Liu
Summary: Green tea and its active extracts are commonly used in dietary supplements, but little is known about their interactions with protein targets. In this study, the researchers used bioinformatics to analyze the interactions between diabetes-related targets and green tea bioactive compounds, leading to the identification of core targets. In vitro experiments demonstrated that the major polyphenolic component of green tea, EGCG, inhibited high glucose-induced cardiomyocyte hypertrophy, inflammation, oxidative stress response, and cellular senescence. The protective effects of EGCG were found to be mediated through PPARG-dependent pathways. This study provides comprehensive insights into the role of EGCG in high glucose-induced myocardial cell injury and aging.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Infectious Diseases
Ze-Jun Pei, Chengcheng Li, Wenna Dai, Zaixiang Lou, Xin Sun, Hongxin Wang, Azmat Ali Khan, Chunpeng Wan
Summary: This study investigated the anti-biofilm activity and mechanism of gallic acid (GA), kaempferol-7-O-glucoside (K7G), and apigenin-7-O-glucoside (A7G) against Staphylococcus aureus and Escherichia coli. A7G showed the strongest anti-biofilm and antibacterial activities. The inhibition of A7G on biofilm was achieved through inhibiting exopolysaccharides (EPS), quorum sensing (QS), and cell surface hydrophobicity (CSH). A7G could be a promising novel antibacterial and anti-biofilm agent for control of biofilm in the food industry.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Chemistry, Applied
Chuying Chen, Qiang Huang, Xuan Peng, Chunpeng Wan, Jiaoke Zeng, Yajie Zhang, Jinyin Chen
Summary: Postharvest 0.3% SA treatment delays senescence in pummelo fruit by inhibiting firmness loss, electrolyte leakage increase, and color change. Transcriptomic data analysis reveals that the regulatory mechanisms involve cell wall modification and phenylpropanoid pathway. SA treatment inhibits CWDEs activities and their encoding gene expression, maintaining cell wall structure and prolonging the storage life of harvested pummelo fruit.
Review
Plant Sciences
Qinan Yin, Xiaoqin Zhang, Suqing Liao, Xiaobo Huang, Chunpeng Craig Wan, Yi Wang
Summary: This study aims to summarize the recent research progress on coagulation mechanisms, new anticoagulant targets, and traditional Chinese medicine. Through literature review, it is found that active components extracted from Chinese medicinal herbs, including Salvia miltiorrhiza, Chuanxiong rhizoma, safflower, and Panax notoginseng, have significant anticoagulant effects and can be potential anticoagulant drugs, but the risk of bleeding is unclear. TF/FVIIa, FVIII, FIX, FXI, FXII, and FXIII have all been evaluated as targets in animal studies or clinical trials. Among them, FXI inhibitors have shown stronger advantages. In conclusion, this review provides a comprehensive resource for potential anticoagulants, and FXI inhibitors can be considered as potential anticoagulant candidates. The anticoagulant effect of traditional Chinese medicine should not be ignored, and more research and new drugs are expected.
