Review
Genetics & Heredity
Lina Moallemi Rad, Alexey Yumashev, Bashdar Mahmud Hussen, Hazha Hadayat Jamad, Soudeh Ghafouri-Fard, Mohammad Taheri, Samaneh Rostami, Vahid Niazi, Mohammadreza Hajiesmaeili
Summary: Mesenchymal stem cells (MSCs) and MSC-derived exosomes (MSC-DEs) have therapeutic potential in ocular diseases by promoting eye injury repair and immune modulation.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Tatiane Barreto da Silva, Evellyn Araujo Dias, Liana Monteiro da Fonseca Cardoso, Jaciara Fernanda Gomes Gama, Luiz Anastacio Alves, Andrea Henriques-Pons
Summary: Liver disease encompasses a range of conditions resulting in tissue damage or altered function, triggered by factors such as viral infections, autoimmunity, genetic mutations, alcohol/drug consumption, fat accumulation, and cancer. Some liver diseases are increasing globally due to obesity, dietary changes, increased alcohol intake, and even the COVID-19 pandemic. Chronic damage or extensive fibrosis may necessitate a liver transplant since the liver's regenerative capacity has limitations. To address organ scarcity, researchers are exploring stem cell transplantation and nanotechnology-based approaches that utilize magnetic nanoparticles for targeted cell delivery to damaged sites. This review highlights the potential of magnetic nanostructure-based strategies for liver disease treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell & Tissue Engineering
Yaping Wang, Tianyun Gao, Bin Wang
Summary: Senescence is a hot topic due to the accumulation of senescent cells and inflammatory factors, leading to various senescence-related diseases. Stem cell-based therapy, particularly using mesenchymal stromal cells (MSCs), is considered a promising strategy to alleviate or cure these diseases.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
D. Kent Arrell, Ruben J. Crespo-Diaz, Satsuki Yamada, Ryounghoon Jeon, Armin Garmany, Sungjo Park, Jeffrey P. Adolf, Christopher Livia, Matthew L. Hillestad, Jozef Bartunek, Atta Behfar, Andre Terzic
Summary: Stem cell paracrine activity, specifically secreted proteins by cardiopoietic cells, play a key role in cardiac repair. Through systems analytics and RNA sequencing, miR-146 was identified as a regulator upstream of the decoded secretome. The therapeutic impact of cardiopoietic cell therapy on infarcted hearts is influenced by the inherent vasculogenic properties and smooth muscle differentiation of the secreted proteins.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Review
Biology
Robert E. Hynds
Summary: Acute and chronic lung diseases are leading causes of morbidity and mortality globally. New therapies are needed to promote the regeneration of functional lung tissue.
Review
Veterinary Sciences
Neza Adamic, Modest Vengust
Summary: Regenerative medicine has provided new therapeutic methods for various diseases, specifically those related to immune system dysregulation. In pulmonary diseases, strategies focusing on tissue regeneration using stem cells or biomedical engineering have emerged to restore functional lung tissue. These strategies not only benefit animal health but can also serve as a translational experimental model for human disease. Clinical trials evaluating cellular treatment for inflammatory lung disease in animals have shown promising results, although our understanding of the mechanisms behind regenerative therapies remains limited.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Przemyslaw Przadka, Krzysztof Buczak, Ewelina Frejlich, Ludwika Gasior, Kamil Suliga, Zdzislaw Kielbowicz
Summary: Regenerative medicine is a rapidly evolving field in human and veterinary medicine, with animal models commonly used for MSCs treatment showing satisfactory results. The increasing demand for alternative treatments in veterinary medicine suggests that cell therapy may be a realistic option for treating diseases in both humans and animals in the future.
Article
Biochemistry & Molecular Biology
Mohamed Nabil, Dina H. Kassem, Azza A. Ali, Hala O. El-Mesallamy
Summary: This study aimed to investigate the therapeutic potential of adipose tissue-derived mesenchymal stem cells (Ad-MSCs) in an Alzheimer's disease (AD) rat model and explore the role of SIRT1. The results demonstrated that transplantation of Ad-MSCs alleviated cognitive impairment in AD rats and exhibited anti-amyloidogenic, antiapoptotic, anti-inflammatory, and neurogenic effects. Furthermore, Ad-MSCs were found to possibly mediate their therapeutic effects through modulating both central and systemic SIRT1 levels.
Review
Biochemistry & Molecular Biology
Katarzyna Czerwiec, Malgorzata Zawrzykraj, Milena Deptula, Aneta Skoniecka, Agata Tyminska, Jacek Zielinski, Adam Kosinski, Michal Pikula
Summary: Adipose-derived mesenchymal stromal cells (AD-MSCs) have gained significant attention due to their easy availability from fat tissue and their regenerative and immunomodulatory properties. These cells show great potential in stem cell-based therapies for wound healing, orthopedic, cardiovascular, and autoimmune diseases. Numerous clinical trials have provided evidence for the effectiveness of AD-MSCs. This article presents current knowledge on AD-MSCs, their applications in pre-clinical models and clinical studies, and highlights the potential for chemically or genetically modified AD-MSCs as the next generation of stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Babak Arjmand, Mina Abedi, Maryam Arabi, Sepideh Alavi-Moghadam, Mostafa Rezaei-Tavirani, Mahdieh Hadavandkhani, Akram Tayanloo-Beik, Ramin Kordi, Peyvand Parhizkar Roudsari, Bagher Larijani
Summary: Cardiovascular disease is the leading cause of adult death worldwide, with myocardial infarction accounting for four fifths of cardiovascular disease deaths. Regenerative medicine, particularly using stem cells to repair the heart, has shown promising benefits as a treatment for ischemic heart disease. Despite the potential of stem cell therapy, more research is needed to fully understand its mechanism of action and its long-term effects on cardiovascular disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Glyn Nigel Stacey, Jie Hao
Summary: In recent years, significant progress has been made in China in establishing hPSCs for the manufacture of cell therapies. The National Stem Cell Resource Center and its partner organizations have over 600 hPSC lines formally recorded, with 47 of them also registered for European Commission funded research projects. This national and international coordination aims to promote the translation of Chinese hPSC-based products into clinical use according to established standards.
CELL PROLIFERATION
(2022)
Article
Cell Biology
Tzu-Cheng Sung, Yi-Peng Jiang, Jhe-Yu Hsu, Qing-Dong Ling, Hao Chen, Suresh S. Kumar, Yung Chang, Shih-Tien Hsu, Qingsong Ye, Akon Higuchi
Summary: This study successfully generated universal hiPSCs without gene editing and evaluated their resistance to immune reactions, demonstrating that the cells maintained stable characteristics even after continuous passages.
CELL PROLIFERATION
(2021)
Review
Biochemistry & Molecular Biology
Matin Chehelgerdi, Fereshteh Behdarvand Dehkordi, Mohammad Chehelgerdi, Hamidreza Kabiri, Hosein Salehian-Dehkordi, Mohammad Abdolvand, Sharareh Salmanizadeh, Mohsen Rashidi, Anoosha Niazmand, Saba Ahmadi, Sara Feizbakhshan, Saber Kabiri, Nasimeh Vatandoost, Tayebeh Ranjbarnejad
Summary: The emergence of iPSCs has revolutionized stem cell research and opened up new avenues for cancer treatment. iPSCs provide a unique platform for investigating the origin of cancer and can be used for personalized treatment and drug testing. This review article discusses the science behind iPSCs, the limitations and challenges in iPSC-based cancer therapy, ethical and social implications, and a comparative analysis with other stem cell types for cancer treatment. It also explores the applications of iPSCs in tumorigenesis and the future of iPSC research in this field.
Review
Cell Biology
Soudeh Ghafouri-Fard, Vahid Niazi, Bashdar Mahmud Hussen, Mir Davood Omrani, Mohammad Taheri, Abbas Basiri
Summary: Extracellular vesicles play important roles in cell-cell communication, inflammation modulation, cell proliferation, and tissue regeneration, with advantages such as lower risk and easier production and storage compared to cell therapy. Particularly, exosomes derived from mesenchymal stem cells are introduced as a therapeutic option for various human diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Veterinary Sciences
Hussein M. M. El-Husseiny, Eman A. A. Mady, Mahmoud A. Y. Helal, Ryou Tanaka
Summary: The use of stem cells in veterinary practice is rapidly evolving, with significant research efforts focused on both experimental animals and clinical cases. Stem cells, particularly mesenchymal stem cells (MSCs), are promising for therapeutic applications due to their immunomodulatory capabilities and ease of isolation. However, challenges remain in their clinical implementation for treating various animal diseases, driving further advancements in stem cell therapies.
VETERINARY SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Allison N. Lau, Matthew G. Vander Heiden
Article
Medicine, Research & Experimental
Anna Sophia McKenney, Allison N., Amritha Varshini Hanasoge Somasundara, Barbara Spitzer, Andrew M. Intlekofer, Jihae Ahn, Kaitlyn Shank, Franck T. Rapaport, Minal A. Patel, Efthymia Papalexi, Alan H. Shih, April Chiu, Elizaveta Freinkman, Esra A. Akbay, Mya Steadman, Raj Nagaraja, Katharine Yen, Julie Teruya-Feldstein, Kwok-Kin Wong, Raajit Rampal, Matthew G. Vander Heiden, Craig B. Thompson, Ross L. Levine
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Article
Physiology
Kristen A. Tropea, Eva Leder, Muhammad Aslam, Allison N. Lau, David M. Raiser, Joo-Hyeon Lee, Vivek Balasubramaniam, Laura E. Fredenburgh, S. Alex Mitsialis, Stella Kourembanas, Carla F. Kim
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2012)
Article
Cell & Tissue Engineering
Stephen J. Curtis, Kerstin W. Sinkevicius, Danan Li, Allison N. Lau, Rebecca R. Roach, Raffaella Zamponi, Amber E. Woolfenden, David G. Kirsch, Kwok-Kin Wong, Carla F. Kim
Article
Cell Biology
Morvarid Mohseni, Jianlong Sun, Allison Lau, Stephen Curtis, Jeffrey Goldsmith, Victor L. Fox, Chongjuan Wei, Marsha Frazier, Owen Samson, Kwok-Kim Wong, Carla Kim, Fernando D. Camargo
NATURE CELL BIOLOGY
(2014)
Article
Multidisciplinary Sciences
Kerstin W. Sinkevicius, Christina Kriegel, Kelly J. Bellaria, Jaewon Lee, Allison N. Lau, Kristen T. Leeman, Pengcheng Zhou, Alexander M. Beede, Christine M. Fillmore, Deborah Caswell, Juliana Barrios, Kwok-Kin Wong, Lynette M. Sholl, Thorsten M. Schlaeger, Roderick T. Bronson, Lucian R. Chirieac, Monte M. Winslow, Marcia C. Haigis, Carla F. Kim
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Biology
Allison N. Lau, Zhaoqi Li, Laura Danai, Anna M. Westermark, Alicia M. Darnell, Raphael Ferreira, Vasilena Gocheva, Sharanya Sivanand, Evan C. Lien, Kiera M. Sapp, Jared R. Mayers, Giulia Biffi, Christopher R. Chin, Shawn M. Davidson, David A. Tuveson, Tyler Jacks, Nicholas J. Matheson, Omer Yilmaz, Matthew G. Vander Heiden
Article
Multidisciplinary Sciences
Rupsa Datta, Sharanya Sivanand, Allison N. Lau, Logan Florek, Anna M. Barbeau, Jeffrey Wyckoff, Melissa C. Skala, Matthew G. Vander Heiden
Summary: The direct interactions between pancreatic stellate cells (PSCs) and cancer cells promote a more oxidized state in cancer cells, overcoming the redox limitations of cell proliferation in pancreatic cancer.
Article
Oncology
Allison N. Lau, William J. Israelsen, Jatin Roper, Mark J. Sinnamon, Larissa Georgeon, Talya L. Dayton, Alissandra L. Hillis, Omer H. Yilmaz, Dolores Di Vizio, Kenneth E. Hung, Matthew G. Vander Heiden
CANCER & METABOLISM
(2017)
