Article
Immunology
Adrian Rice, Mohit Verma, Emily Voigt, Peter Battisti, Sam Beaver, Sierra Reed, Kyle Dinkins, Shivani Mody, Lise Zakin, Shiho Tanaka, Brett Morimoto, C. Anders Olson, Elizabeth Gabitzsch, Jeffrey T. Safrit, Patricia Spilman, Corey Casper, Patrick Soon-Shiong
Summary: The study assessed the enhanced immune responses in CD-1 mice by heterologous vaccination with two different nucleic acid-based COVID-19 vaccines. It was found that one vaccine showed better T-cell and humoral responses, and the sera from vaccinated mice exhibited high neutralizing activity against various strains of the virus.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Terri C. Thayer, Joanne Davies, James A. Pearson, Stephanie J. Hanna, Li Wen, F. Susan Wong
Summary: Our results suggest that a loss of NOD-LNSC MHC-independent suppressive mechanisms may contribute to diabetes development. In contrast, non-MHC-matched, control C57BL/6 mouse LNSC suppressed T-cell receptor engagement by anti-CD3/CD28 via MHC-independent mechanisms, modifying antigen sensitivity and effector function.
Article
Multidisciplinary Sciences
Jorge Postigo-Fernandez, Rebuma Firdessa-Fite, Remi J. Creusota
Summary: Antigen-specific immunotherapy using tailored epitopes delivered through proteins, peptides, or nucleic acids can reestablish tolerance and potentially provide precision medicine approach for treating tissue-specific autoimmune diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Immunology
Felix Lamontagne, Vinay Khatri, Philippe St-Louis, Steve Bourgault, Denis Archambault
Summary: Vaccination is crucial for saving lives and reducing economic burden caused by infectious diseases. However, there are still many diseases without effective vaccines. Bacterial protein nanoassemblies have gained attention as a delivery system for antigens due to their advantages such as biocompatibility and ability to stimulate immune responses. Understanding the structural and physicochemical properties of these protein nanoassemblies is essential for designing effective vaccines.
Article
Pharmacology & Pharmacy
Yuchong Peng, Rong Tang, Liuyang Ding, Rirong Zheng, Youhong Liu, Linglong Yin, Yongming Fu, Tanggang Deng, Xiong Li
Summary: In this study, a potentially effective component, diosgenin (DSG), was identified from traditional Chinese medicine (TCM) for the treatment of prostate cancer (PCa) by using network pharmacology and molecular docking. DSG specifically targeted UHRF1 protein and induced its degradation through the ubiquitin-proteasome pathway. DSG reduced DNA methylation and increased the expression of tumor suppressor genes, resulting in cell cycle arrest, cellular senescence, and inhibition of tumor growth. This study revealed a novel anticancer mechanism of DSG and provided a promising strategy for discovering new molecule-targeted drugs from small-molecule natural products.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Erolcan Sayar, Radhika A. Patel, Ilsa M. Coleman, Martine P. Roudier, Ailin Zhang, Pallabi Mustafi, Jin-Yih Low, Brian Hanratty, Lisa S. Ang, Vipul Bhatia, Mohamed Adil, Hasim Bakbak, David A. Quigley, Michael T. Schweizer, Jessica E. Hawley, Lori Kollath, Lawrence D. True, Felix Y. Feng, Neil H. Bander, Eva Corey, John K. Lee, Colm Morrissey, Roman Gulati, Peter S. Nelson, Michael C. Haffner
Summary: Prostate-specific membrane antigen (PSMA) expression is heterogeneous in metastatic castration-resistant prostate cancer (mCRPC), with some cases showing no detectable PSMA and others showing heterogeneous expression across metastases. Loss of PSMA is associated with epigenetic changes, including CpG methylation and loss of H3K27 acetylation at the FOLH1 locus. Treatment with HDAC inhibitors can reverse this repression and restore PSMA expression. These findings provide insights into PSMA expression patterns and regulation in mCRPC, and suggest a potential therapeutic strategy using epigenetic therapies to augment PSMA levels.
Review
Biochemistry & Molecular Biology
Zachary C. Stensland, John C. Cambier, Mia J. Smith
Summary: Targeted therapies focusing on autoantigen-specific B cells have shown potential for more precise treatment of autoimmune disorders, while also presenting challenges that need to be addressed for their clinical applicability.
Article
Biochemistry & Molecular Biology
Li-Kuang Tsai, Min Peng, Chia-Chun Chang, Luan Wen, Lin Liu, Xiubin Liang, Y. Eugene Chen, Jie Xu, Li-Ying Sung
Summary: This study reveals that ZSCAN4 promotes DNA repair in mESCs by interacting with PARP1 and reducing DSB. PARP1 binds directly to ZSCAN4, with the second α-helix and the fourth zinc finger motif of ZSCAN4 playing a critical role in this interaction.
CELL AND BIOSCIENCE
(2023)
Article
Genetics & Heredity
Takashi Tsuyama, Kumiko Fujita, Ryosuke Sasaki, Shiori Hamanaka, Yuki Sotoyama, Akira Ogawa, Kana Kusuzaki, Yutaro Azuma, Shusuke Tada
Summary: RecQ4, a member of the RecQ helicase family, is involved in DNA double-strand break repair pathways NHEJ and HR. The N-terminal region N598 of Xenopus RecQ4 inhibits DNA end joining and affects the association of Ku70, potentially influencing the choice of DSB repair pathway.
Article
Genetics & Heredity
Heyuan Zhang, Nanhui Chen, Zhihai Deng, Yang Mai, Limin Deng, Guo Chen, Yutong Li, Bin Pan, Weifeng Zhong
Summary: The study found that ANT2 expression was significantly upregulated in PCa tissues, while miR-137 expression was reduced. Overexpression of ANT2 promoted proliferation, migration, and invasion of PCa cells, whereas miR-137 mimics inhibited these behaviors by antagonizing expression of ANT2. This suggests that ANT2, a target gene of miR-137, plays a role in the development of PCa and may provide new options for targeted therapy.
FRONTIERS IN GENETICS
(2021)
Article
Multidisciplinary Sciences
Thaiphi Luu, Julie F. Cheung, Jennifer Baccon, Hanspeter Waldner
Summary: This study investigated the role of dendritic cells (DCs) in the development of autoimmune disease, particularly in relation to self-reactive CD4(+) T cells in multiple sclerosis (MS). The findings indicate that DC deficiency can reduce immune tolerance to self-antigens, such as PLP, leading to accelerated onset of EAE. Additionally, non-DC cells were shown to effectively present CNS myelin antigens to self-reactive T cells in the absence of DCs, exacerbating EAE.
Article
Pharmacology & Pharmacy
Chenglong Li, Yangyun Han, Xianjin Luo, Can Qian, Yang Li, Huaiyu Su, Guangshen Du
Summary: Rheumatoid arthritis is a disease caused by the immune system attacking its own joint tissues. There is currently no cure for RA, but immunomodulatory nano-preparations show potential in regulating immune responses and inducing antigen-specific immune tolerance.
Article
Biochemistry & Molecular Biology
A. Cannistraci, P. Hascoet, A. Ali, P. Mundra, N. W. Clarke, V Pavet, R. Marais
Summary: This study explores the prognostic potential and functional role of miRs in prostate cancer, and identifies miR-378a and GLUT1 as potential therapeutic targets.
Article
Biochemistry & Molecular Biology
Yasuyuki Akasaka, Shun Hasei, Yukino Ohata, Machi Kanna, Yusuke Nakatsu, Hideyuki Sakoda, Midori Fujishiro, Akifumi Kushiyama, Hiraku Ono, Akio Matsubara, Nobuyuki Hinata, Tomoichiro Asano, Takeshi Yamamotoya
Summary: Auraptene has been found to activate AMPK and inhibit proliferation of prostate cancer cells. By increasing the AMP/ATP ratio, Auraptene potentially suppresses prostate cancer progression through multiple molecular mechanisms, including suppression of the mTOR-S6K pathway, reduced lipid synthesis, and androgen receptor downregulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Franziska Hoefer, Marcus Groettrup
Summary: The endoplasmic reticulum is a cell organelle with high protein density, making it susceptible to damage from protein aggregates. Research suggests that a preemptive quality control pathway can help attenuate the impact of protein folding stress on ER import.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Genetics & Heredity
Michael Stanton, Michelle Cronin, Panos Lehouritis, Mark Tangney
CURRENT GENE THERAPY
(2015)
Article
Multidisciplinary Sciences
Anzhelika G. Vorobyeva, Michael Stanton, Aurelien Godinat, Kjetil B. Lund, Grigory G. Karateev, Kevin P. Francis, Elizabeth Allen, Juri G. Gelovani, Emmet McCormack, Mark Tangney, Elena A. Dubikovskaya
Article
Multidisciplinary Sciences
Panos Lehouritis, Joanne Cummins, Michael Stanton, Carola T. Murphy, Florence O. McCarthy, Gregor Reid, Camilla Urbaniak, William L. Byrne, Mark Tangney
SCIENTIFIC REPORTS
(2015)
Article
Biotechnology & Applied Microbiology
Camilla Urbaniak, Gregory B. Gloor, Muriel Brackstone, Leslie Scott, Mark Tangney, Gregor Reid
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2016)
Article
Chemistry, Multidisciplinary
Panos Lehouritis, Michael Stanton, Florence O. McCarthy, Matthieu Jeavons, Mark Tangney
JOURNAL OF CONTROLLED RELEASE
(2016)
Article
Multidisciplinary Sciences
Carola Murphy, Elizabeth Rettedal, Panos Lehouritis, Ciaran Devoy, Mark Tangney
Editorial Material
Biotechnology & Applied Microbiology
Yensi Flores Bueso, Mark Tangney
TRENDS IN BIOTECHNOLOGY
(2017)
Article
Pathology
Natalie Suff, Rajvinder Karda, Juan A. Diaz, Joanne Ng, Julien Baruteau, Dany Perocheau, Mark Tangney, Peter W. Taylor, Donald Peebles, Suzanne M. K. Buckley, Simon N. Waddington
AMERICAN JOURNAL OF PATHOLOGY
(2018)
Review
Chemistry, Multidisciplinary
Yensi Flores Bueso, Panos Lehouritis, Mark Tangney
JOURNAL OF CONTROLLED RELEASE
(2018)
Article
Biotechnology & Applied Microbiology
Camilla Urbaniak, Joanne Cummins, Muriel Brackstone, Jean M. Macklaim, Gregory B. Gloor, Chwanrow K. Baban, Leslie Scott, Deidre M. O'Hanlon, Jeremy P. Burton, Kevin P. Francis, Mark Tangney, Gregor Reid
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2014)
Article
Biotechnology & Applied Microbiology
Michelle Cronin, Fabrice Le Boeuf, Carola Murphy, Dominic G. Roy, Theresa Falls, John C. Bell, Mark Tangney
Article
Multidisciplinary Sciences
Maria C. Whelan, Garrett Casey, John O. Larkin, Barbara-Ann Guinn, Gerald C. O'Sullivan, Mark Tangney
Editorial Material
Pharmacology & Pharmacy
Glenn Hogan, Mark Tangney
TRENDS IN PHARMACOLOGICAL SCIENCES
(2018)
Article
Medicine, Research & Experimental
Hugh O'Connor, John MacSharry, Yensi Flores Bueso, Sinead Lindsay, Emma L. Kavanagh, Mark Tangney, Marguerite Clyne, Radka Saldova, Amanda McCann
DISCOVERY MEDICINE
(2018)
Review
Pharmacology & Pharmacy
Panos Lehouritis, Glenn Hogan, Mark Tangney
ADVANCED DRUG DELIVERY REVIEWS
(2017)