Protein localization as a principal feature of the etiology and comorbidity of genetic diseases

The Mitochondrial Proteome and Human Disease

(2010) Sarah E. Calvo et al.   Annual Review of Genomics and Human Genetics

Genome-wide inferring gene–phenotype relationship by walking on the heterogeneous network

(2010) Yongjin Li et al.   BIOINFORMATICS

Genetic bases of mitochondrial respiratory chain disorders

(2010) Agnès Rötig   DIABETES & METABOLISM

From phenotype to gene: Detecting disease-specific gene functional modules via a text-based human disease phenotype network construction

(2010) Shi-Hua Zhang et al.   FEBS LETTERS

Towards a knowledge-based Human Protein Atlas

(2010) Mathias Uhlen et al.   NATURE BIOTECHNOLOGY

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

VnD: a structure-centric database of disease-related SNPs and drugs

(2010) Jin Ok Yang et al.   NUCLEIC ACIDS RESEARCH

Functional modules, mutational load and human genetic disease

(2010) Norann A. Zaghloul et al.   TRENDS IN GENETICS

Network-Based Elucidation of Human Disease Similarities Reveals Common Functional Modules Enriched for Pluripotent Drug Targets

(2010) Silpa Suthram et al.   PLoS Computational Biology

Comparison of concept recognizers for building the Open Biomedical Annotator

(2009) Nigam H Shah et al.   BMC BIOINFORMATICS

Prediction of disease-related mutations affecting protein localization

(2009) Kirsti Laurila et al.   BMC GENOMICS

Treating lysosomal storage diseases with pharmacological chaperones: from concept to clinics

(2009) Giancarlo Parenti   EMBO Molecular Medicine

Matrilin-3 activates the expression of osteoarthritis-associated genes in primary human chondrocytes

(2009) Andreas R. Klatt et al.   FEBS LETTERS

Construction of Functional Interaction Networks through Consensus Localization Predictions of the Human Proteome

(2009) Solip Park et al.   JOURNAL OF PROTEOME RESEARCH

Tissue specificity and the human protein interaction network

(2009) Alice Bossi et al.   Molecular Systems Biology

The impact of cellular networks on disease comorbidity

(2009) Juyong Park et al.   Molecular Systems Biology

Genetic diseases of connective tissues: cellular and extracellular effects of ECM mutations

(2009) John F. Bateman et al.   NATURE REVIEWS GENETICS

BioPortal: ontologies and integrated data resources at the click of a mouse

(2009) N. F. Noy et al.   NUCLEIC ACIDS RESEARCH

A Dynamic Network Approach for the Study of Human Phenotypes

(2009) César A. Hidalgo et al.   PLoS Computational Biology

Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network

(2009) Bolan Linghu et al.   GENOME BIOLOGY

A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

(2008) David J. Pagliarini et al.   CELL

Protein misfolding and disease: from the test tube to the organism

(2008) Leila M Luheshi et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Modularity in the genetic disease-phenotype network

(2008) Xingpeng Jiang et al.   FEBS LETTERS

Network-based global inference of human disease genes

(2008) Xuebing Wu et al.   Molecular Systems Biology

Network-based prediction of human tissue-specific metabolism

(2008) Tomer Shlomi et al.   NATURE BIOTECHNOLOGY

Detecting shared pathogenesis from the shared genetics of immune-related diseases

(2008) Alexandra Zhernakova et al.   NATURE REVIEWS GENETICS

A large-scale analysis of tissue-specific pathology and gene expression of human disease genes and complexes

(2008) K. Lage et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Network properties of genes harboring inherited disease mutations

(2008) I. Feldman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The implications of human metabolic network topology for disease comorbidity

(2008) D.- S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design Logic of a Cannabinoid Receptor Signaling Network That Triggers Neurite Outgrowth

(2008) K. D. Bromberg et al.   SCIENCE

Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome

(2008) H. Lin et al.   SCIENCE