Article
Medicine, Research & Experimental
Yi-Hua Chen, Jian-Lin Wu, Neng-Yuan Hu, Jia-Pai Zhuang, Wei-Peng Li, Sheng-Rong Zhang, Xiao-Wen Li, Jian-Ming Yang, Tian-Ming Gao
Summary: The study was supported by grants from the National Natural Science Foundation of China, the Key Area Research and Development Program of Guangdong Province, the Guangdong Basic and Applied Basic Research Foundation, the Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence Fund, and the Science and Technology Program of Guangzhou.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Mathematics
Muhammad Aamir, Awais Yousaf, Ibtisam Masmali, Abdul Razaq
Summary: In this study, we find all the distinct fragments by joining two circuits of length 6, Omega(1) and Omega(2), and calculate the total number of fragments that satisfy certain conditions.
JOURNAL OF MATHEMATICS
(2023)
Article
Neurosciences
Sam Cooler, Gregory W. Schwartz
Summary: A systematic spatial offset between ON and OFF receptive subfields in F-mini-ON retinal ganglion cells was discovered, originating from a network of electrical synapses instead of dendritic positions. The asymmetry in morphology and connectivity of these RGCs explains their receptive field offset, affecting the precision of edge-location representation. This RGC network forms a new electrical channel combining the ON and OFF feedforward pathways within the output layer of the retina.
NATURE NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
Hongchae Baek, Yaoheng Yang, Christopher Pham Pacia, Lu Xu, Yimei Yue, Michael R. Bruchas, Hong Chen
Summary: This study aimed to compare the motor responses induced by focused ultrasound (FUS) neuromodulation under mechanical and mechanothermal effects. Brain tissue temperature rise was quantified, showing a greater range in the mechanothermal group. Evoked electromyographic responses indicated different temporal dynamics between mechanical and mechanothermal effects.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jian Zhou, Hamdan Hamdan, Hari Krishna Yalamanchili, Kaifang Pang, Amy E. Pohodich, Joanna Lopez, Yingyao Shao, Juan A. Oses-Prieto, Lifang Li, Wonho Kim, Mark A. Durham, Sameer S. Bajikar, Donna J. Palmer, Philip Ng, Michelle L. Thompson, E. Martina Bebin, Amelie J. Mueller, Alma Kuechler, Antje Kampmeier, Tobias B. Haack, Alma L. Burlingame, Zhandong Liu, Matthew N. Rasband, Huda Y. Zoghbi
Summary: MeCP2 plays a critical role in Rett syndrome and MECP2 duplication syndrome. It interacts with a transcription factor, TCF20, at the chromatin interface, and together they regulate the expression of neuronal genes. Reduction of TCF20 partially rescues the behavioral deficits caused by MECP2 overexpression. A patient with a mutation in the PHF14 subunit of the TCF20 complex, disrupting the MeCP2-PHF14-TCF20 interaction, exhibits Rett-like neurological features.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Antonello Baldassarre, Maria Serena Filardi, Sara Spadone, Stefania Della Penna, Giorgia Committeri
Summary: The study found that rates of early and late post-training motor skill learning were positively correlated with the strength of functional connections among regions within the brain. Early learning was associated with connections within cerebellar regions, while late learning was related to connections between cortical and subcortical motor areas. This suggests that spontaneous brain activity carries behaviorally relevant information for experience-dependent cognitive operations over time.
Article
Medicine, Research & Experimental
Daniella G. de Paula, Tabata M. Bohlen, Thais Tessari Zampieri, Naira S. Mansano, Henrique R. Vieira, Daniela O. Gusmao, Frederick Wasinski, Jose Donato Jr, Renata Frazao
Summary: In the first mouse model, GH deficiency due to ARH lesions caused late sexual maturation and infertility in male mice. In the second mouse model, despite late puberty onset, the majority of male mice with severe GH deficiency due to a Ghrhr gene mutation were fertile. These findings suggest that spontaneous GH deficiency during development does not compromise the kisspeptin system and that different regions of the hypothalamus play specific roles in male reproductive function.
Article
Biochemistry & Molecular Biology
Yifei Yao, Yiming Tang, Yun Zhou, Zhongyuan Yang, Guanghong Wei
Summary: This study reveals that the disruptive effects and modes of baicalein on alpha-synuclein fibrils are polymorphism-dependent. It can damage both WT and E46K/H50Q mutant alpha-synuclein fibrils, making it a potential drug candidate to alleviate the pathological process of Parkinson's disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Neurosciences
Chloe Delepine, Jennifer Shih, Keji Li, Pierre Gaudeaux, Mriganka Sur
Summary: This study reveals that manipulations of astrocytes in the primary motor cortex (M1) can affect motor learning and execution, as well as neuronal population coding. Decreased levels of astrocyte glutamate transporter 1 (GLT1) result in unstable and impaired movement trajectories, while increased astrocyte Gq signaling leads to decreased performance rates, delayed response times, and impaired trajectories. The study also demonstrates that astrocytes coordinate M1 neuronal activity during motor learning and suggests their involvement in regulating neurotransmitter transport and calcium signaling.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Lindsey A. Lee, Samantha K. Barrick, Ada E. Buvoli, Jonathan Walklate, W. Tom Stump, Michael Geeves, Michael J. Greenberg, Leslie A. Leinwand
Summary: For a long time, sarcomeric myosin heavy chain proteins were believed to only exist in striated muscles where they function as molecular motors. However, an evolutionarily ancient member of this myosin family, MYH7b, has been found in mammalian nonmuscle tissues and is linked to hereditary hearing loss. The functional effects of mutations in MYH7b were unknown until now. This study investigates the effects of two hearing loss-associated mutations on the motor activity, structural and assembly properties of MYH7b.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Neurosciences
Laura C. Rice, Anila M. D'Mello, Catherine J. Stoodley
Summary: The human cerebellum contributes to both motor and non-motor processes, with different subregions supporting sensorimotor and broader cognitive functions. Transcranial direct current stimulation (tDCS) targeting different cerebellar regions had differential effects on language task performance and whole-brain functional activation patterns, with tDCS on the right posterolateral cerebellum improving task accuracy and increasing activation in task-relevant brain regions. In contrast, tDCS targeting the sensorimotor cerebellum did not impact task performance significantly.
Article
Biochemistry & Molecular Biology
Vahid Esmaeili, Anastasiia Oryshchuk, Reza Asri, Keita Tamura, Georgios Foustoukos, Yanqi Liu, Romain Guiet, Sylvain Crochet, Carl C. H. Petersen
Summary: This study explores the changes in the activity of excitatory and inhibitory neurons in the mouse sensorimotor cortex before and after learning a whisker detection task. The results indicate that the changes in whisker-evoked activity of these neurons differ in primary and secondary whisker motor cortices, but show similar patterns in primary and secondary orofacial motor cortices. These findings suggest that the balance of excitation and inhibition in local circuits, along with changes in long-range synaptic inputs, may contribute to the performance of delayed sensory-to-motor transformation.
Article
Multidisciplinary Sciences
Christoph Neumayr, Vanja Haberle, Leonid Serebreni, Katharina Karner, Oliver Hendy, Ann Boija, Jonathan E. Henninger, Charles H. Li, Karel Stejskal, Gen Lin, Katharina Bergauer, Michaela Pagani, Martina Rath, Karl Mechtler, Cosmas D. Arnold, Alexander Stark
Summary: This paper investigates different types of enhancers and their reliance on cofactors. The authors find that some enhancers can function without commonly used cofactors, regulating distinct gene regulatory programs.
Article
Clinical Neurology
Anastasia Brodovskaya, Tamal Batabyal, Shinnosuke Shiono, Huayu Sun, Jaideep Kapur
Summary: This study investigates the role of the thalamus and corpus callosum in bilateral cortical synchronization. The findings suggest that the thalamus generates bilateral sleep spindles and primarily generalized absence seizures, while the corpus callosum mediates the spread of seizures bilaterally.
ANNALS OF NEUROLOGY
(2022)
Article
Mathematics
Hanan Alolaiyan, Muhammad Aamir, Awais Yousaf, Abdul Razaq
Summary: Graham Higman was the first to study the transitive actions of the extended modular group PGL(2, Z) over PL(F-q) = F-q boolean OR(I infinity) graphically and named it as coset diagram. In these diagrams, a closed path of edges and triangles is known as a circuit. This study formulates combinatorial sequences and determines the number of distinct equivalence classes of length-6 circuits for a fixed number of triangles.
JOURNAL OF MATHEMATICS
(2022)
Review
Neurosciences
Xiang-Zhen Kong, Merel C. Postema, Tulio Guadalupe, Carolien de Kovel, Premika S. W. Boedhoe, Martine Hoogman, Samuel R. Mathias, Daan van Rooij, Dick Schijven, David C. Glahn, Sarah E. Medland, Neda Jahanshad, Sophia Thomopoulos, Jessica A. Turner, Jan Buitelaar, Theo G. M. van Erp, Barbara Franke, Simon E. Fisher, Odile A. van den Heuvel, Lianne Schmaal, Paul M. Thompson, Clyde Francks
Summary: Left-right asymmetry of the human brain is associated with psychiatric disorders, but previous research findings have been inconsistent. The ENIGMA-Laterality Working Group conducted large-scale studies and mapped the average asymmetry in healthy brains. They also found associations between brain asymmetry and age, sex, handedness, and brain volume. Moreover, they identified subtle changes in cortical thickness asymmetry in autism spectrum disorder and altered subcortical asymmetry in pediatric obsessive-compulsive disorder.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Lara M. Wierenga, Gaelle E. Doucet, Danai Dima, Ingrid Agartz, Moji Aghajani, Theophilus N. Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Ole A. Andreassen, Alan Anticevic, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt, Josiane Bourque, Anouk den Braber, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Geraldo F. Busatto, Vince D. Calhoun, Erick J. Canales-Rodriguez, Dara M. Cannon, Xavier Caseras, Francisco X. Castellanos, Tiffany M. Chaim-Avancini, Christopher R. K. Ching, Vincent P. Clark, Patricia J. Conrod, Annette Conzelmann, Fabrice Crivello, Christopher G. Davey, Erin W. Dickie, Stefan Ehrlich, Dennis Van't Ent, Simon E. Fisher, Jean-Paul Fouche, Barbara Franke, Paola Fuentes-Claramonte, Eco J. C. de Geus, Annabella Di Giorgio, David C. Glahn, Ian H. Gotlib, Hans J. Grabe, Oliver Gruber, Patricia Gruner, Raquel E. Gur, Ruben C. Gur, Tiril P. Gurholt, Lieuwe de Haan, Beathe Haatveit, Ben J. Harrison, Catharina A. Hartman, Sean N. Hatton, Dirk J. Heslenfeld, Odile A. van den Heuvel, Ian B. Hickie, Pieter J. Hoekstra, Sarah Hohmann, Avram J. Holmes, Martine Hoogman, Norbert Hosten, Fleur M. Howells, Hilleke E. Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony C. James, Jiyang Jiang, Erik G. Jonsson, John A. Joska, Andrew J. Kalnin, Marieke Klein, Laura Koenders, Knut K. Kolskar, Bernd Kramer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina S. Lebedeva, Phil H. Lee, Christine Lochner, Marise W. J. Machielsen, Sophie Maingault, Nicholas G. Martin, Ignacio Martinez-Zalacain, David Mataix-Cols, Bernard Mazoyer, Brenna C. McDonald, Colm McDonald, Andrew M. McIntosh, Katie L. McMahon, Genevieve McPhilemy, Dennis van der Meer, Jose M. Menchon, Jilly Naaijen, Lars Nyberg, Jaap Oosterlaan, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J. Portella, Joaquim Radua, Andreas Reif, Genevieve Richard, Joshua L. Roffman, Pedro G. P. Rosa, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Salvador Sarro, Theodore D. Satterthwaite, Andrew J. Saykin, Mauricio H. Serpa, Kang Sim, Andrew Simmons, Jordan W. Smoller, Iris E. Sommer, Carles Soriano-Mas, Dan J. Stein, Lachlan T. Strike, Philip R. Szeszko, Henk S. Temmingh, Sophia Thomopoulos, Alexander S. Tomyshev, Julian N. Trollor, Anne Uhlmann, Ilya M. Veer, Dick J. Veltman, Aristotle Voineskos, Henry Volzke, Henrik Walter, Lei Wang, Yang Wang, Bernd Weber, Wei Wen, John D. West, Lars T. Westlye, Heather C. Whalley, Steven C. R. Williams, Katharina Wittfeld, Daniel H. Wolf, Margaret J. Wright, Yuliya N. Yoncheva, Marcus Zanetti, Georg C. Ziegler, Greig de Zubicaray, Paul M. Thompson, Eveline A. Crone, Sophia Frangou, Christian K. Tamnes
Summary: Males exhibit greater variability than females in many traits, which may have implications for understanding sex differences in health and disease. A mega-analysis of brain structure variability based on MRI data of 16,683 healthy individuals spanning nine decades of life reveals significant patterns of greater male than female between-subject variance in subcortical volumes, cortical surface area, and cortical thickness. These sex differences are present in childhood and may be influenced by early life genetic or gene-environment interaction mechanisms. The findings underscore the importance of individual differences within each sex, which may contribute to sex-specific vulnerability to disorders.
HUMAN BRAIN MAPPING
(2022)
Article
Anatomy & Morphology
Tulio Guadalupe, Xiang-Zhen Kong, Sophie E. A. Akkermans, Simon E. Fisher, Clyde Francks
Summary: The study demonstrates a relationship between hemispheric asymmetries of auditory processing and grey matter asymmetry in subcortical structures, indicating the need to investigate subcortical structures in addition to auditory cortex in relation to hemispheric dominance for speech processing.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Health Care Sciences & Services
Tannia Valeria Carpio-Arias, Jefferson Santiago Piedra-Andrade, Tomas Marcelo Nicolalde-Cifuentes, Maria Victoria Padilla-Samaniego, Estephany Carolina Tapia-Veloz, Maria Fernanda Vinueza-Veloz
Summary: This study aimed to examine the association between mobility restriction and mental health outcomes among highly-educated young adults in Ecuador. The findings showed that mobility restrictions during the COVID-19 pandemic were associated with worse self-reported mental health, particularly among women and young individuals.
Article
Biochemistry & Molecular Biology
Fenja Schlag, Andrea G. Allegrini, Jan Buitelaar, Ellen Verhoef, Marjolein van Donkelaar, Robert Plomin, Kaili Rimfeld, Simon E. Fisher, Beate St Pourcain
Summary: This study systematically investigated the genetic links between various mental health conditions and social symptoms. The results revealed associations between social behavior and genetic risk for ADHD, ASD, MD, and schizophrenia. The study also identified differences in the genetic architecture across different disorders and the impact of age, reporter, and social traits on genetic effects.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Rachel M. Brouwer, Marieke Klein, Katrina L. Grasby, Hugo G. Schnack, Neda Jahanshad, Jalmar Teeuw, Sophia I. Thomopoulos, Emma Sprooten, Carol E. Franz, Nitin Gogtay, William S. Kremen, Matthew S. Panizzon, Loes M. Olde Loohuis, Christopher D. Whelan, Moji Aghajani, Clara Alloza, Dag Alanaes, Eric Artiges, Rosa Ayesa-Arriola, Gareth J. Barker, Mark E. Bastin, Elisabet Blok, Erlend Boen, Isabella A. Breukelaar, Joanna K. Bright, Elizabeth E. L. Buimer, Robin Bulow, Dara M. Cannon, Simone Ciufolini, Nicolas A. Crossley, Christienne G. Damatac, Paola Dazzan, Casper L. de Mol, Sonja M. C. de Zwarte, Sylvane Desrivieres, Covadonga M. Diaz-Caneja, Nhat Trung Doan, Katharina Dohm, Juliane H. Froehner, Janik Goltermann, Antoine Grigis, Dominik Grotegerd, Laura K. M. Han, Mathew A. Harris, Catharina A. Hartman, Sarah J. Heany, Walter Heindel, Dirk J. Heslenfeld, Sarah Hohmann, Bernd Ittermann, Philip R. Jansen, Joost Janssen, Tianye Jia, Jiyang Jiang, Christiane Jockwitz, Temmuz Karali, Daniel Keeser, Martijn G. J. C. Koevoets, Rhoshel K. Lenroot, Berend Malchow, Rene C. W. Mandl, Vicente Medel, Susanne Meinert, Catherine A. Morgan, Thomas W. Muehleisen, Leila Nabulsi, Nils Opel, Victor Ortiz-Garcia de la Foz, Bronwyn J. Overs, Marie-Laure Paillere Martinot, Ronny Redlich, Tiago Reis Marques, Jonathan Repple, Gloria Roberts, Gennady V. Roshchupkin, Nikita Setiaman, Elena Shumskaya, Frederike Stein, Gustavo Sudre, Shun Takahashi, Anbupalam Thalamuthu, Diana Tordesillas-Gutierrez, Aad van der Lugt, Neeltje E. M. van Haren, Joanna M. Wardlaw, Wei Wen, Henk-Jan Westeneng, Katharina Wittfeld, Alyssa H. Zhu, Andre Zugman, Nicola J. Armstrong, Gaia Bonfiglio, Janita Bralten, Shareefa Dalvie, Gail Davies, Marta Di Forti, Linda Ding, Gary Donohoe, Andreas J. Forstner, Javier Gonzalez-Penas, Joao P. O. F. T. Guimaraes, Georg Homuth, Jouke-Jan Hottenga, Maria J. Knol, John B. J. Kwok, Stephanie Le Hellard, Karen A. Mather, Yuri Milaneschi, Derek W. Morris, Markus M. Noethen, Sergi Papiol, Marcella Rietschel, Marcos L. Santoro, Vidar M. Steen, Jason L. Stein, Fabian Streit, Rick M. Tankard, Alexander Teumer, Dennis van 't Ent, Dennis van der Meer, Kristel R. van Eijk, Evangelos Vassos, Javier Vazquez-Bourgon, Stephanie H. Witt, Hieab H. H. Adams, Ingrid Agartz, David Ames, Katrin Amunts, Ole A. Andreassen, Celso Arango, Tobias Banaschewski, Bernhard T. Baune, Sintia I. Belangero, Arun L. W. Bokde, Dorret I. Boomsma, Rodrigo A. Bressan, Henry Brodaty, Jan K. Buitelaar, Wiepke Cahn, Svenja Caspers, Sven Cichon, Benedicto Crespo-Facorro, Simon R. Cox, Udo Dannlowski, Torbjorn Elvsashagen, Thomas Espeseth, Peter G. Falkai, Simon E. Fisher, Herta Flor, Janice M. Fullerton, Hugh Garavan, Penny A. Gowland, Hans J. Grabe, Tim Hahn, Andreas Heinz, Manon Hillegers, Jacqueline Hoare, Pieter J. Hoekstra, Mohammad A. Ikram, Andrea P. Jackowski, Andreas Jansen, Erik G. Jonsson, Rene S. Kahn, Tilo Kircher, Mayuresh S. Korgaonkar, Axel Krug, Herve Lemaitre, Ulrik F. Malt, Jean-Luc Martinot, Colm McDonald, Philip B. Mitchell, Ryan L. Muetzel, Robin M. Murray, Frauke Nees, Igor Nenadic, Jaap Oosterlaan, Roel A. Ophoff, Pedro M. Pan, Brenda W. J. H. Penninx, Luise Poustka, Perminder S. Sachdev, Giovanni A. Salum, Peter R. Schofield, Gunter Schumann, Philip Shaw, Kang Sim, Michael N. Smolka, Dan J. Stein, Julian N. Trollor, Leonard H. van den Berg, Jan H. Veldink, Henrik Walter, Lars T. Westlye, Robert Whelan, Tonya White, Margaret J. Wright, Sarah E. Medland, Barbara Franke, Paul M. Thompson, Hilleke E. Hulshoff Pol
Summary: This study identified genetic variants that affect rates of brain growth and atrophy, suggesting a link to early brain development and neurodegenerative processes. The findings provide insights into the biological pathways underlying brain development and aging, as well as their association with psychiatric disorders like depression and schizophrenia.
NATURE NEUROSCIENCE
(2022)
Letter
Neurosciences
Yun-Long Xu, Lin Zhu, Zi-Jun Chen, Xiao-Fei Deng, Pei-Dong Liu, Shan Li, Bing-Chun Lin, Chuan-Zhong Yang, Wei Xu, Kui-Kui Zhou, Ying-Jie Zhu
NEUROSCIENCE BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Zijun Chen, Gaowei Chen, Jiafeng Zhong, Shaolei Jiang, Shishi Lai, Hua Xu, Xiaofei Deng, Fengling Li, Shanshan Lu, Kuikui Zhou, Changlin Li, Zhongdong Liu, Xu Zhang, Yingjie Zhu
Summary: This study reveals the crucial role of neurotensin-positive neurons in the lateral septum (LSNts) in regulating hedonic feeding. The LSNts neurons project to the tuberal nucleus (TU) via GABA signaling to regulate hedonic feeding, while the neurotensin signal from LSNts -> the supramammillary nucleus (SUM) is sufficient to suppress overall feeding. In vivo calcium imaging and optogenetic manipulation demonstrate the activation and inhibition of specific populations of LSNts neurons during feeding, contributing to food seeking and consumption, respectively.
MOLECULAR PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Gokberk Alagoz, Barbara Molz, Else Eising, Dick Schijven, Clyde Francks, Jason L. Stein, Simon E. Fisher
Summary: This study investigates how genetic factors contribute to altered brain anatomy and connectivity during human evolution by analyzing neuroimaging and genetic data, and integrating with genomic annotations for different aspects of human evolution. The findings reveal the relationship between genetic variants and cortical surface area, white-matter connectivity, and specific brain regions involved in language, memory, and socioemotional processing. The study also identifies regulatory elements and genes implicated in neurogenesis that contribute to neuroanatomical variation. Additionally, the study uncovers the impact of Neanderthal ancestry on white-matter connectivity. Overall, these findings shed light on the complexities of our evolutionary past.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Kuikui Zhou, Hua Xu, Shanshan Lu, Shaolei Jiang, Guoqiang Hou, Xiaofei Deng, Miao He, Yingjie Zhu
Summary: This study investigates the afferent-specific circuitry of NAc and its role in controlling reward and aversion. The authors present evidence for two distinct pathways in the NAc that mediate positive reinforcement and aversion, respectively.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Elliot Sollis, Joery den Hoed, Marti Quevedo, Sara B. Estruch, Arianna Vino, Dick H. W. Dekkers, Jeroen A. A. Demmers, Raymond Poot, Pelagia Deriziotis, Simon E. Fisher
Summary: TBR1 is a neuron-specific transcription factor involved in brain development and associated with neurodevelopmental disorders such as autism spectrum disorder, intellectual disability, and speech delay. Through affinity purification coupled to mass spectrometry, approximately 250 putative TBR1-interaction partners have been identified, including transcription factors, chromatin modifiers, and proteins related to autism and intellectual disability.
HUMAN MOLECULAR GENETICS
(2023)
Article
Multidisciplinary Sciences
Zhiqiang Sha, Dick Schijven, Simon E. Fisher, Clyde Francks
Summary: By applying brain-wide tractography to diffusion images from 30,810 adults, a study identified significant heritability for network connectivity measures. They found 325 genetic loci, of which 80% were previously unassociated with brain metrics. Enrichment analyses implicated neurodevelopmental processes and prenatal brain expression. Multivariate association profiles linked specific genetic loci to connectivity between core regions of the language network, as well as psychiatric, neurological, and behavioral traits.
Article
Neurosciences
Fabian Heim, Simon E. Fisher, Constance Scharff, Carel ten Cate, Katharina Riebel
Summary: The search for molecular underpinnings of human vocal communication has focused on genes encoding forkhead-box transcription factors, as rare disruptions of FOXP1, FOXP2, and FOXP4 have been linked to disorders involving speech and language deficits. In male songbirds, experimentally altered expression levels of these transcription factors impair song production learning. It is unknown whether the deficits observed after different FoxP manipulations in songbirds are due to auditory processing, motor function, or auditory-motor integration.
Article
Nutrition & Dietetics
Brian M. Cavagnari, Dario Javier Guerrero-Vaca, Tannia Valeria Carpio-Arias, Samuel Duran-Aguero, Andres Fernando Vinueza-Veloz, Maria Paulina Robalino-Valdivieso, Yadira Alejandra Morejon-Teran, Maria Fernanda Vinueza-Veloz
Summary: The present study aimed to investigate the relationship between the double burden of malnutrition and gross motor development in infants. By observing and analyzing 5900 infants under 24 months of age, it was found that malnutrition had a negative impact on gross motor development, including sitting, crawling, and walking. Therefore, public health measures are needed to prevent the detrimental effects of malnutrition on infant development.
CLINICAL NUTRITION
(2023)
Review
Linguistics
Srishti Nayak, Peyton L. Coleman, Eniko Ladanyi, Rachana Nitin, Daniel E. Gustavson, Simon E. Fisher, Cyrille L. Magne, Reyna L. Gordon
Summary: This study focuses on the impact of musicality on language acquisition and development, proposing the Musical Abilities, Pleiotropy, Language, and Environment (MAPLE) framework. The framework suggests that musical and language-related abilities may share genetic architecture and neural endophenotypes, and be influenced by genetic pleiotropy and enriched environments.
NEUROBIOLOGY OF LANGUAGE
(2022)